Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model
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Background/Aims: DA-9701 is a newly developed drugmade from the vegetal extracts of Pharbitidis semen and Corydalistuber. The aim of this study was to evaluate the effectof DA-9701 on colorectal distension (CRD)-induced visceralhypersensitivity in a rat model. Methods: Male Sprague-Dawley rats were subjected to neonatal colon irritation (CI)using CRD at 1 week after birth (CI group). At 6 weeks afterbirth, CRD was applied to these rats with a pressure of 20 to90 mm Hg, and changes in the mean arterial pressure (MAP)were measured at baseline (i.e., without any drug administration)and after the administration of different doses of DA-9701. Results: In the absence of DA-9701, the MAP changesafter CRD were significantly higher in the CI group than in thecontrol group at all applied pressures. In the control group,MAP changes after CRD were not significantly affected bythe administration of DA-9701. In the CI group, however, theadministration of DA-9701 resulted in a significant decreasein MAP changes after CRD. The administration of DA-9701 ata dose of 1.0 mg/kg produced a more significant decreasein MAP changes than the 0.3 mg/kg dose. Conclusions: Theadministration of DA-9701 resulted in a significant increasein pain threshold in rats with CRD-induced visceral hypersensitivity.
Abstract
Background/Aims: DA-9701 is a newly developed drugmade from the vegetal extracts of Pharbitidis semen and Corydalistuber. The aim of this study was to evaluate the effectof DA-9701 on colorectal distension (CRD)-induced visceralhypersensitivity in a rat model. Methods: Male Sprague-Dawley rats were subjected to neonatal colon irritation (CI)using CRD at 1 week after birth (CI group). At 6 weeks afterbirth, CRD was applied to these rats with a pressure of 20 to90 mm Hg, and changes in the mean arterial pressure (MAP)were measured at baseline (i.e., without any drug administration)and after the administration of different doses of DA-9701. Results: In the absence of DA-9701, the MAP changesafter CRD were significantly higher in the CI group than in thecontrol group at all applied pressures. In the control group,MAP changes after CRD were not significantly affected bythe administration of DA-9701. In the CI group, however, theadministration of DA-9701 resulted in a significant decreasein MAP changes after CRD. The administration of DA-9701 ata dose of 1.0 mg/kg produced a more significant decreasein MAP changes than the 0.3 mg/kg dose. Conclusions: Theadministration of DA-9701 resulted in a significant increasein pain threshold in rats with CRD-induced visceral hypersensitivity.
참고문헌 (37)
- Delvaux M, "Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome", Gut, 51(Suppl 1:), pp.i67~i71 (2002)
- Azpiroz F, "Mechanisms of hypersensitivity in IBS and functional disorders", Neurogastroenterol Motil, 19(1 Suppl), pp.62~88 (2007)
- Ritchie J, "Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome", Gut, 14, pp.125~132 (1973)
- Mertz H, "Altered rectal perception is a biological marker of patients with irritable bowel syndrome", Gastroenterology, 109, pp.40~52 (1995)
- Whitehead WE, "Tolerance for rectosigmoid distention in irritable bowel syndrome", Gastroenterology, 98(5 Pt 1), pp.1187~1192 (1990)
- Bradette M, "Visceral perception in health and functional dyspepsia: crossover study of gastric distension with placebo and domperidone", Dig Dis Sci, 36, pp.52~58 (1991)
- Mearin F, "The origin of symptoms on the brain-gut axis in functional dyspepsia", Gastroenterology, 101, pp.999~1006 (1991)
- Holzer P, "Pharmacology of inflammatory pain : local alteration in receptors and mediators", Dig Dis, 27(Suppl 1), pp.24~30 (2009)
- Bortolotti M, "Effect of red pepper on symptoms of irritable bowel syndrome: preliminary study", Dig Dis Sci, 56, pp.3288~3295 (2011)
- Lee TH, "Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber", Phytomedicine, 15, pp.836~843 (2008)
- Seok Choi, "Induction of Pacemaker Currents by DA-9701, a Prokinetic Agent, in Interstitial Cells of Cajal from Murine Small Intestine", Molecules and Cells, 27(3), pp.307~312 (2009), 한국분자세포생물학회
- Kim ER, "Effects of DA-9701, a novel prokinetic agent, on gastric accommodation in conscious dogs", J Gastroenterol Hepatol, 27, pp.766~772 (2012)
- Lee TH, "Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function", J Pharmacol Exp Ther, 338, pp.917~924 (2011)
- Lee TH, "Effects of corydaline from Corydalis tuber on gastric motor function in an animal model", Biol Pharm Bull, 33, pp.958~962 (2010)
- Gershon MD, "Review article : serotonin receptors and transporters--roles in normal and abnormal gastrointestinal motility", Aliment Pharmacol Ther, 20(Suppl 7), pp.3~14 (2004)
- Kanazawa M, "Visceral hypersensitivity in irritable bowel syndrome", J Gastroenterol Hepatol, 26(Suppl 3), pp.119~121 (2011)
- Sikander A, "Role of serotonin in gastrointestinal motility and irritable bowel syndrome", Clin Chim Acta, 403, pp.47~55 (2009)
- Lin C, "Long-term sensitization of primary afferents in adult rats exposed to neonatal colon pain", Brain Res, 971, pp.73~82 (2003)
- Mantides A, "Gut motility and visceral perception in IBS patients", Ann Gastroentol, 15, pp.240~247 (2002)
- Seminowicz DA, "Regional gray matter density changes in brains of patients with irritable bowel syndrome", Gastroenterology, 139, pp.48~57 (2010)
- Akbar A, "Review article: visceral hypersensitivity in irritable bowel syndrome: molecular mechanisms and therapeutic agents", Aliment Pharmacol Ther, 30, pp.423~435 (2009)
- McLean PG, "5-HT in the enteric nervous system: gut function and neuropharmacology", Trends Neurosci, 30, pp.9~13 (2007)
- Barnes NM, "A review of central 5-HT receptors and their function", Neuropharmacology, 38, pp.1083~1152 (1999)
- Tian XY, "Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway", Brain Res, 1088, pp.101~108 (2006)
- Chu D, "Electroacupuncture at ST-36 relieves visceral hypersensitivity and decreases 5-HT(3) receptor level in the colon in chronic visceral hypersensitivity rats", Int J Colorectal Dis, 26, pp.569~574 (2011)
- Moskwa A, "Serum serotonin concentration and urine 5-hydroxyindole acetic acid excretion in patients with irritable bowel syndrome", Pol Merkur Lekarski, 22, pp.366~368 (2007)
- Zhang LY, "Luminal serotonin time-dependently modulates vagal afferent driven antinociception in response to colorectal distention in rats", Neurogastroenterol Motil, 23, pp.62~69 (2011)
- Dinan TG, "Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function", Life Sci, 58, pp.1683~1694 (1996)
- O’Mahony SM, "5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction", Neurogastroenterol Motil, 22, pp.573~578 (2010)
- Matsuzaki H, "Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT1A receptor function in adult rats", Psychopharmacology, 214, pp.329~337 (2011)
- Heisler LK, "Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice", Proc Natl Acad Sci U S A, 95, pp.15049~15054 (1998)
- Kusserow H, "Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin 1A receptors", Brain Res Mol Brain Res, 129, pp.104~116 (2004)
- Leventopoulos M, "Early deprivation leads to long-term reductions in motivation for reward and 5-HT1A binding and both effects are reversed by fluoxetine", Neuropharmacology, 56, pp.692~701 (2009)
- Vicentic A, "Maternal separation alters serotonergic transporter densities and serotonergic 1A receptors in rat brain", Neuroscience, 140, pp.355~365 (2006)
- Stamatakis A, "Effect of neonatal handling on serotonin 1A sub-type receptors in the rat hippocampus", Neuroscience, 140, pp.1~11 (2006)
- Sivarao DV, "Effect of the 5HT1A receptor partial agonist buspirone on colorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat", Eur J Pharmacol, 494, pp.23~29 (2004)
- Vera-Portocarrero LP, "Reversal of inflammatory and noninflammatory visceral pain by central or peripheral actions of sumatriptan", Gastroenterology, 135, pp.1369~1378 (2008)
