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Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

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Background/Aims: DA-9701 is a newly developed drugmade from the vegetal extracts of Pharbitidis semen and Corydalistuber. The aim of this study was to evaluate the effectof DA-9701 on colorectal distension (CRD)-induced visceralhypersensitivity in a rat model. Methods: Male Sprague-Dawley rats were subjected to neonatal colon irritation (CI)using CRD at 1 week after birth (CI group). At 6 weeks afterbirth, CRD was applied to these rats with a pressure of 20 to90 mm Hg, and changes in the mean arterial pressure (MAP)were measured at baseline (i.e., without any drug administration)and after the administration of different doses of DA-9701. Results: In the absence of DA-9701, the MAP changesafter CRD were significantly higher in the CI group than in thecontrol group at all applied pressures. In the control group,MAP changes after CRD were not significantly affected bythe administration of DA-9701. In the CI group, however, theadministration of DA-9701 resulted in a significant decreasein MAP changes after CRD. The administration of DA-9701 ata dose of 1.0 mg/kg produced a more significant decreasein MAP changes than the 0.3 mg/kg dose. Conclusions: Theadministration of DA-9701 resulted in a significant increasein pain threshold in rats with CRD-induced visceral hypersensitivity.

Abstract

Background/Aims: DA-9701 is a newly developed drugmade from the vegetal extracts of Pharbitidis semen and Corydalistuber. The aim of this study was to evaluate the effectof DA-9701 on colorectal distension (CRD)-induced visceralhypersensitivity in a rat model. Methods: Male Sprague-Dawley rats were subjected to neonatal colon irritation (CI)using CRD at 1 week after birth (CI group). At 6 weeks afterbirth, CRD was applied to these rats with a pressure of 20 to90 mm Hg, and changes in the mean arterial pressure (MAP)were measured at baseline (i.e., without any drug administration)and after the administration of different doses of DA-9701. Results: In the absence of DA-9701, the MAP changesafter CRD were significantly higher in the CI group than in thecontrol group at all applied pressures. In the control group,MAP changes after CRD were not significantly affected bythe administration of DA-9701. In the CI group, however, theadministration of DA-9701 resulted in a significant decreasein MAP changes after CRD. The administration of DA-9701 ata dose of 1.0 mg/kg produced a more significant decreasein MAP changes than the 0.3 mg/kg dose. Conclusions: Theadministration of DA-9701 resulted in a significant increasein pain threshold in rats with CRD-induced visceral hypersensitivity.

참고문헌 (37)

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