본문 바로가기
KERD
논문KCI 등재

Celiac Disease: A Disorder Emerging from Antiquity, Its Evolving Classification and Risk, and Potential New Treatment Paradigms

Hugh J. Freeman
거트앤리버 소화기연관학회협의회|2015.01|Gut and Liver|제9권 제1호|pp. 28-37

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

Celiac diseaseCeliac disease historyOccult and latent celiac diseaseSprue-like intestinal diseaseCeliac disease therapy

초록

Celiac disease is a chronic genetically based gluten-sensitive immune-mediated enteropathic process primarily affecting the small intestinal mucosa. The disorder classically presents with diarrhea and weight loss; however, more recently, it has been characterized by subclinical occult or latent disease associated with few or no intestinal symptoms. Diagnosis depends on the detection of typical histopathological biopsy changes followed by a gluten-free diet response. A broad range of clinical disorders may mimic celiac disease, along with a wide range of drugs and other therapeutic agents. Recent and intriguing archeological data, largely from the Gobleki Tepe region of the Fertile Crescent, indicate that celiac disease probably emerged as humans transitioned from hunter-gatherer groups to societies dependent on agriculture to secure a stable food supply. Longitudinal studies performed over several decades have suggested that changes in the prevalence of the disease, even apparent epidemic disease, may be due to superimposed or novel environmental factors that may precipitate its appearance. Recent therapeutic approaches are being explored that may supplement, rather than replace, gluten-free diet therapy and permit more nutritional options for future management.

Abstract

Celiac disease is a chronic genetically based gluten-sensitive immune-mediated enteropathic process primarily affecting the small intestinal mucosa. The disorder classically presents with diarrhea and weight loss; however, more recently, it has been characterized by subclinical occult or latent disease associated with few or no intestinal symptoms. Diagnosis depends on the detection of typical histopathological biopsy changes followed by a gluten-free diet response. A broad range of clinical disorders may mimic celiac disease, along with a wide range of drugs and other therapeutic agents. Recent and intriguing archeological data, largely from the Gobleki Tepe region of the Fertile Crescent, indicate that celiac disease probably emerged as humans transitioned from hunter-gatherer groups to societies dependent on agriculture to secure a stable food supply. Longitudinal studies performed over several decades have suggested that changes in the prevalence of the disease, even apparent epidemic disease, may be due to superimposed or novel environmental factors that may precipitate its appearance. Recent therapeutic approaches are being explored that may supplement, rather than replace, gluten-free diet therapy and permit more nutritional options for future management.

참고문헌 (106)

  1. Freeman HJ, "Recent advances in celiac disease", World J Gastroenterol, 17, pp.2259~2272 (2011)
  2. Gujral N, "Celiac disease: prevalence, diagnosis, pathogenesis and treatment", World J Gastroenterol, 18, pp.6036~6059 (2012)
  3. Freeman HJ, "Pearls and pitfalls in the diagnosis of adult celiac disease", Can J Gastroenterol, 22, pp.273~280 (2008)
  4. Freeman HJ, "Neurological disorders in adult celiac disease", Can J Gastroenterol, 22, pp.909~911 (2008)
  5. Freeman HJ, "Risk factors in familial forms of celiac disease", World J Gastroenterol, 16, pp.1828~1831 (2010)
  6. Ivarsson A, "Epidemic of coeliac disease in Swedish children", Acta Paediatr, 89, pp.165~171 (2000)
  7. Lebwohl B, "The unfolding story of celiac disease risk factors", Clin Gastroenterol Hepatol, 12, pp.632~635 (2014)
  8. Freeman HJ, "Strongly positive tissue transglutaminase antibody assays without celiac disease", Can J Gastroenterol, 18, pp.25~28 (2004)
  9. Rubio-Tapia A, "ACG clinical guidelines:diagnosis and management of celiac disease", Am J Gastroenterol, 108, pp.656~676 (2013)
  10. Freeman HJ, "The Neolithic revolution and subsequent emergence of the celiac affection", Int J Celiac Dis, 1, pp.19~22 (2013)
  11. Lohi S, "Increasing prevalence of coeliac disease over time", Aliment Pharmacol Ther, 26, pp.1217~1225 (2007)
  12. Dietrich O, "The role of cult and feasting in the emergence of Neolithic communities:new evidence from Gobekli Tepe, south-eastern Turkey", Antiquity, 86, pp.674~695 (2012)
  13. Heun M, "Site of Einkorn wheat domestication identified by DNA fingerprinting", Science, 278, pp.1312~1314 (1997)
  14. Adams F, "On the coeliac affection: the extant works of Aretaeus, the Cappadocian", pp.350~351 (1856), Sydenham Society
  15. Gasbarrini G, "When was celiac disease born? The Italian case from the archeologic site of Cosa", J Clin Gastroenterol, 44, pp.502~503 (2010)
  16. Gee SJ, "On the coeliac affection", St Bartholomews Hosp Rep, 24, pp.17~20 (1888)
  17. Haas SV, "The value of the banana in the treatment of celiac disease", Am J Dig Child, 28, pp.421~437 (1924)
  18. van Berge-Henegouwen GP, "Pioneer in the gluten free diet: Willem-Karel Dicke 1905-1962, over 50 years of gluten free diet", Gut, 34, pp.1473~1475 (1993)
  19. Paulley JW, "Observation on the aetiology of idiopathic steatorrhoea:jejunal and lymph-node biopsies", Br Med J, 2, pp.1318~1321 (1954)
  20. Freeman HJ, "Non-dietary forms of treatment for adult celiac disease", World J Gastrointest Pharmacol Ther, 4, pp.108~112 (2013)
  21. Freeman HJ, "Celiac disease associated with primary biliary cirrhosis in a Coast Salish native", Can J Gastroenterol, 8, pp.105~107 (1994)
  22. Suttles WP, "Coast Salish essays", pp.45~63 (1987), University of Washington Press
  23. Hugh J. Freeman, "Adult Celiac Disease and Its Malignant Complications", Gut and Liver, 3(4), pp.237~246 (2009), 거트앤리버 발행위원회
  24. Weinstein WM, "Latent celiac sprue", Gastroenterology, 66, pp.489~493 (1974)
  25. Freeman HJ, "Multifocal small bowel lymphoma and latent celiac sprue", Gastroenterology, 90, pp.1992~1997 (1986)
  26. Freeman HJ, "Refractory celiac disease and sprue-like intestinal disease", World J Gastroenterol, 14, pp.828~830 (2008)
  27. Freeman HJ, "Sprue-like intestinal disease", Int J Celiac Dis, 2, pp.6~10 (2014)
  28. Ruemmele FM, "Loss-of-function of MYO5B is the main cause of microvillus inclusion disease:15 novel mutations and a CaCo-2 RNAi cell model", Hum Mutat, 31, pp.544~551 (2010)
  29. Wiegerinck CL, "Loss of syntaxin 3 causes variant microvillus inclusion disease", Gastroenterology, 147, pp.65~68 (2014)
  30. Gooding IR, "Idiopathic smallintestinal inflammation after colectomy for ulcerative colitis", Clin Gastroenterol Hepatol, 6, pp.707~709 (2008)
  31. Rosenfeld GA, "Severe and extensive enteritis following colectomy for ulcerative colitis", Can J Gastroenterol, 26, pp.866~867 (2012)
  32. Robinson JW, "Intestinal malabsorption in the experimental animal", Gut, 13, pp.938~945 (1972)
  33. Freeman HJ, "Drug-induced sprue-like intestinal disease", Int J Celiac Dis, 2, pp.49~53 (2014)
  34. Freeman HJ, "Sulindac-associated small bowel lesion", J Clin Gastroenterol, 8, pp.569~571 (1986)
  35. Ziegler TR, "Severe villus atrophy and chronic malabsorption induced by azathioprine", Gastroenterology, 124, pp.1950~1957 (2003)
  36. Ducloux D, "Mycophenolate mofetil-induced villous atrophy", Transplantation, 66, pp.1115~1116 (1998)
  37. Kamar N, "Villous atrophy induced by mycophenolate mofetil in renal-transplant patients", Transpl Int, 17, pp.463~467 (2004)
  38. Tapia O, "Duodenal villous atrophy associated with Mycophenolate mofetil: report of one case", Rev Med Chil, 138, pp.590~594 (2010)
  39. Jacobson ED, "Malabsorptive syndrome induced by neomyclin: morphologic alterations in the jejunal mucosa", J Lab Clin Med, 56, pp.245~250 (1960)
  40. Race TF, "Intestinal malabsorption induced by oral colchicines: comparison with neomycin and cathartic agents", Am J Med Sci, 259, pp.32~41 (1970)
  41. Wright N, "The cell cycle time in the flat (avillous) mucosa of the human small intestine", Gut, 14, pp.603~606 (1973)
  42. Trier JS, "Morphologic alterations induced by methotrexate in the mucosa of human proximal intestine. I. Serial observations by light microscopy", Gastroenterology, 42, pp.295~305 (1962)
  43. Rubio-Tapia A, "Severe spruelike enteropathy associated with olmesartan", Mayo Clin Proc, 87, pp.732~738 (2012)
  44. Gentile NM, "Association between ipilimumab and celiac disease", Mayo Clin Proc, 88, pp.414~417 (2013)
  45. Cooke WT, "Celiac disease", pp.11~22 (1984), Churchill Livingstone
  46. Mylotte M, "Incidence of coeliac disease in the West of Ireland", Br Med J, 1, pp.703~705 (1973)
  47. Kowlessar OD, "Celiac disease", Med Clin North Am, 54, pp.647~656 (1970)
  48. Fasano A, "Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study", Arch Intern Med, 163, pp.286~292 (2003)
  49. Mäki M, "Prevalence of Celiac disease among children in Finland", N Engl J Med, 348, pp.2517~2524 (2003)
  50. West J, "Seroprevalence, correlates, and characteristics of undetected coeliac disease in England", Gut, 52, pp.960~965 (2003)
  51. Wong RC, "A comparison of 13 guinea pig and human anti-tissue transglutaminase antibody ELISA kits", J Clin Pathol, 55, pp.488~494 (2002)
  52. Van Meensel B, "Diagnostic accuracy of ten second-generation (human) tissue transglutaminase antibody assays in celiac disease", Clin Chem, 50, pp.2125~2135 (2004)
  53. Punglia RS, "Effect of verification bias on screening for prostate cancer by measurement of prostate-specific antigen", N Engl J Med, 349, pp.335~342 (2003)
  54. Rewers M, "Epidemiology of celiac disease: what are the prevalence, incidence, and progression of celiac disease?", Gastroenterology, 128, pp.S47~S51 (2005)
  55. Cavell B, "Increasing incidence of childhood coeliac disease in Sweden: results of a national study", Acta Paediatr, 81, pp.589~592 (1992)
  56. Carlsson AK, "Serological screening for celiac disease in healthy 2.5-year-old children in Sweden", Pediatrics, 107, pp.42~45 (2001)
  57. Catassi C, "High prevalence of undiagnosed coeliac disease in 5280 Italian students screened by antigliadin antibodies", Acta Paediatr, 84, pp.672~676 (1995)
  58. Cook HB, "Adult coeliac disease: prevalence and clinical significance", J Gastroenterol Hepatol, 15, pp.1032~1036 (2000)
  59. Hovell CJ, "High prevalence of coeliac disease in a population-based study from Western Australia: a case for screening?", Med J Aust, 175, pp.247~250 (2001)
  60. Gomez JC, "Prevalence of celiac disease in Argentina: screening of an adult population in the La Plata area", Am J Gastroenterol, 96, pp.2700~2704 (2001)
  61. Shamir R, "The use of a single serological marker underestimates the prevalence of celiac disease in Israel: a study of blood donors", Am J Gastroenterol, 97, pp.2589~2594 (2002)
  62. Hoffenberg EJ, "A prospective study of the incidence of childhood celiac disease", J Pediatr, 143, pp.308~314 (2003)
  63. Catassi C, "Why is coeliac disease endemic in the people of the Sahara?", Lancet, 354, pp.647~648 (1999)
  64. Rubio-Tapia A, "Increased prevalence and mortality in undiagnosed celiac disease", Gastroenterology, 137, pp.88~93 (2009)
  65. Catassi C, "Natural history of celiac disease autoimmunity in a USA cohort followed since 1974", Ann Med, 42, pp.530~538 (2010)
  66. Freeman HJ, "Detection of adult celiac disease with duodenal screening biopsies over a 30-year period", Can J Gastroenterol, 27, pp.405~408 (2013)
  67. Namatovu F, "Celiac disease risk varies between birth cohorts, generating hypotheses about causality: evidence from 36 years of populationbased follow-up", BMC Gastroenterol, 14, pp.59~ (2014)
  68. West J, "Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study", Am J Gastroenterol, 109, pp.757~768 (2014)
  69. Jiang LL, "Is adult celiac disease really uncommon in Chinese?", J Zhejiang Univ Sci B, 10, pp.168~171 (2009)
  70. 권태근, "Celiac Disease 1예", 대한소화기학회지, 61(6), pp.338~342 (2013), 대한소화기학회
  71. Freeman HJ, "Biopsy-defined adult celiac disease in Asian-Canadians", Can J Gastroenterol, 17, pp.433~436 (2003)
  72. Yuan J, "The tip of the “celiac iceberg” in China:a systematic review and meta-analysis", PLoS One, 8, pp.e81151~ (2013)
  73. Stene LC, "Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study", Am J Gastroenterol, 101, pp.2333~2340 (2006)
  74. Riddle MS, "Pathogen-specific risk of celiac disease following bacterial causes of foodborne illness: a retrospective cohort study", Dig Dis Sci, 58, pp.3242~3245 (2013)
  75. Kondrashova A, "Lower economic status and inferior hygienic environment may protect against celiac disease", Ann Med, 40, pp.223~231 (2008)
  76. Szajewska H, "Systematic review: early infant feeding and the prevention of coeliac disease", Aliment Pharmacol Ther, 36, pp.607~618 (2012)
  77. Norris JM, "Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease", JAMA, 293, pp.2343~2351 (2005)
  78. Carroccio A, "Searching for wheat plants with low toxicity in celiac disease: between direct toxicity and immunologic activation", Dig Liver Dis, 43, pp.34~39 (2011)
  79. Spaenij-Dekking L, "Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients", Gastroenterology, 129, pp.797~806 (2005)
  80. Makharia GK, "Current and emerging therapy for celiac disease", Front Med, 1, pp.6~ (2014)
  81. Pinier M, "Polymeric binders suppress gliadin-induced toxicity in the intestinal epithelium", Gastroenterology, 136, pp.288~298 (2009)
  82. Pinier M, "The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues", Gastroenterology, 142, pp.316~325 (2012)
  83. Sollid LM, "Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules", Immunogenetics, 64, pp.455~460 (2012)
  84. Gass J, "Prolyl endopeptidases", Cell Mol Life Sci, 64, pp.345~355 (2007)
  85. Garcia-Horsman JA, "Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease", Scand J Gastroenterol, 42, pp.562~571 (2007)
  86. Piper JL, "High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue", Biochemistry, 41, pp.386~393 (2002)
  87. Khosla C, "Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying gliadin peptides", Gastroenterology, 129, pp.1362~1363 (2005)
  88. Gass J, "Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat", J Pharmacol Exp Ther, 318, pp.1178~1186 (2006)
  89. Stepniak D, "Highly efficient gluten degradation with a newly identified prolyl endoprotease:implications for celiac disease", Am J Physiol Gastrointest Liver Physiol, 291, pp.G621~G629 (2006)
  90. Mitea C, "Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease", Gut, 57, pp.25~32 (2008)
  91. Siegel M, "Rational design of combination enzyme therapy for celiac sprue", Chem Biol, 13, pp.649~658 (2006)
  92. Siegel M, "Safety, tolerability, and activity of ALV003: results from two phase 1 single, escalatingdose clinical trials", Dig Dis Sci, 57, pp.440~450 (2012)
  93. Tye-Din JA, "The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo", Clin Immunol, 134, pp.289~295 (2010)
  94. Gass J, "Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue", Gastroenterology, 133, pp.472~480 (2007)
  95. Lähdeaho ML, "Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease", Gastroenterology, 146, pp.1649~1658 (2014)
  96. Di Cagno R, "Gluten-free sourdough wheat baked goods appear safe for young celiac patients:a pilot study", J Pediatr Gastroenterol Nutr, 51, pp.777~783 (2010)
  97. Greco L, "Safety for patients with celiac disease of baked goods made of wheat flour hydrolyzed during food processing", Clin Gastroenterol Hepatol, 9, pp.24~29 (2011)
  98. De Angelis M, "VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue", Biochim Biophys Acta, 1762, pp.80~93 (2006)
  99. Madsen K, "Probiotic bacteria enhance murine and human intestinal epithelial barrier function", Gastroenterology, 121, pp.580~591 (2001)
  100. Fasano A, "Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease", Lancet, 355, pp.1518~1519 (2000)
  101. Lammers KM, "Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3", Gastroenterology, 135, pp.194~204 (2008)
  102. Paterson BM, "The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study", Aliment Pharmacol Ther, 26, pp.757~766 (2007)
  103. Kelly CP, "Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study", Aliment Pharmacol Ther, 37, pp.252~262 (2013)
  104. Molberg O, "T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase", Eur J Immunol, 31, pp.1317~1323 (2001)
  105. Maiuri L, "Unexpected role of surface transglutaminase type II in celiac disease", Gastroenterology, 129, pp.1400~1413 (2005)
  106. Silano M, "Antagonist peptides of the gliadin T-cell stimulatory sequences:a therapeutic strategy for celiac disease", J Clin Gastroenterol, 42(3), pp.S191~S192 (2008)

관련 논문AI추천

Adult Celiac Disease and Its Malignant ComplicationsHugh J. Freeman거트앤리버 소화기연관학회협의회 · Gut and Liver2009 · 제3권 제4호Seronegative Celiac Disease in Patients with Isolated Refractory Dyspepsia and Gastroesophageal Reflux DiseaseBoral Baris, Gumurdulu Yuksel, Tokmak Salih거트앤리버 소화기연관학회협의회 · Gut and Liver2022 · 제16권 제3호Coexistence of Excessive Weight Gain and Celiac Disease in Children: An Unusual Familial ConditionAlexandra Madè, Corrado Regalbuto, Hellas Cena, Mariasole Magistrali, Maureen M. Leonard, Valeria Calcaterra대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2019 · 제22권 제4호Celiac Disease in South JordanEyad Altamimi대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2017 · 제20권 제4호Early Infant Feeding Practices May Influence the Onset of Symptomatic Celiac DiseaseAakash Sharma, Alok Goyal, Rajkumar Gupta, Shailja Vajpayee, Shiv Dayal Sharma대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2016 · 제19권 제4호Clinical Characteristics of Celiac Disease and Dietary Adherence to Gluten-Free Diet among Saudi ChildrenAhmed Al Sarkhy, Aziz Alanazi, Elshazaly Saeed, Mohammad I. El Mouzan, Sharifa Alghamdi, Shirin Anil and Asaad Assiri대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2015 · 제18권 제1호

이 간행물의 다른 논문 (17건)

The Elderly Also Deserves to Undergo Therapeutic Endoscopy Safely under Sedation with Propofol by Gastroenterologists김상균pp. 1-2Benign Colorectal Stricture: An Answer to the Balloon or Stent Question?이호수, 변정식pp. 3-4Diagnosis and Management of High Risk Group for Gastric Cancer김나영, 윤혁pp. 5-17Current and Emerging Biologics for Ulcerative Colitis박성철, 진윤태pp. 18-27Safety of Gastroenterologist-Guided Sedation with Propofol for Upper Gastrointestinal Therapeutic Endoscopy in Elderly Patients Compared with Younger PatientsChika Kusano, Masakatsu Fukuzawa, Fuminori Moriyasu, Takao Itoi, Takuji Gotoda, Masaya Nonakapp. 38-42
원문 보기