Predictive Factors for Severe Outcomes in Ischemic Colitis
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background/Aims: Ischemic colitis includes a wide clinical spectrum ranging from mild to severe forms. This study aimed to determine the factors that are related to the occurrence of severe ischemic colitis. Methods: This multicenter study was conducted retrospectively in Korea. The patients were divided into mild and severe groups. This study surveyed clinical characteristics, blood tests, endoscopic findings, and imaging studies. Results: In the comparison of comorbidities, the severe group had a higher ratio of chronic kidney disease than the mild group (p=0.001). In the blood test, the severe group had a reduced number of platelets (p=0.018) and a higher C-reactive protein value (p=0.001). The severe group had a higher ratio of involvement of the right colon (p=0.026). The Eastern Cooperative Oncology Group (ECOG) performance status score of the patients showed that the severe group had higher scores than the mild group (p=0.003). A multivariate analysis showed that chronic kidney disease and high ECOG performance status scores were significant risk factors. Conclusions: If patients diagnosed with ischemic colitis are also treated for chronic kidney disease or have poor performance status, more attention and early intervention are necessary.
Abstract
Background/Aims: Ischemic colitis includes a wide clinical spectrum ranging from mild to severe forms. This study aimed to determine the factors that are related to the occurrence of severe ischemic colitis. Methods: This multicenter study was conducted retrospectively in Korea. The patients were divided into mild and severe groups. This study surveyed clinical characteristics, blood tests, endoscopic findings, and imaging studies. Results: In the comparison of comorbidities, the severe group had a higher ratio of chronic kidney disease than the mild group (p=0.001). In the blood test, the severe group had a reduced number of platelets (p=0.018) and a higher C-reactive protein value (p=0.001). The severe group had a higher ratio of involvement of the right colon (p=0.026). The Eastern Cooperative Oncology Group (ECOG) performance status score of the patients showed that the severe group had higher scores than the mild group (p=0.003). A multivariate analysis showed that chronic kidney disease and high ECOG performance status scores were significant risk factors. Conclusions: If patients diagnosed with ischemic colitis are also treated for chronic kidney disease or have poor performance status, more attention and early intervention are necessary.
참고문헌 (25)
- Brandt LJ, "Colonic ischemia", Surg Clin North Am, 72, pp.203~229 (1992)
- Higgins PD, "Systematic review: the epidemiology of ischaemic colitis", Aliment Pharmacol Ther, 19, pp.729~738 (2004)
- Añón R, "Factors predicting poor prognosis in ischemic colitis", World J Gastroenterol, 12, pp.4875~4878 (2006)
- Toursarkissian B, "Ischemic colitis", Surg Clin North Am, 77, pp.461~470 (1997)
- West BR, "Comparison of transient ischemic colitis with that requiring surgical treatment", Surg Gynecol Obstet, 151, pp.366~368 (1980)
- Abel ME, "Ischemic colitis: comparison of surgical and nonoperative management", Dis Colon Rectum, 26, pp.113~115 (1983)
- Guttormson NL, "Mortality from ischemic colitis", Dis Colon Rectum, 32, pp.469~472 (1989)
- Longo WE, "Ischemic colitis: patterns and prognosis", Dis Colon Rectum, 35, pp.726~730 (1992)
- Diamond SM, "Bowel infarction as a cause of death in dialysis patients", JAMA, 256, pp.2545~2547 (1986)
- Oken MM, "Toxicity and response criteria of the Eastern Cooperative Oncology Group", Am J Clin Oncol, 5, pp.649~655 (1982)
- Bower TC, "Ischemic colitis", Surg Clin North Am, 73, pp.1037~1053 (1993)
- Brandt LJ, "Anatomic patterns, patient characteristics, and clinical outcomes in ischemic colitis: a study of 313 cases supported by histology", Am J Gastroenterol, 105, pp.2245~2252 (2010)
- Sotiriadis J, "Ischemic colitis has a worse prognosis when isolated to the right side of the colon", Am J Gastroenterol, 102, pp.2247~2252 (2007)
- Medina C, "Outcome of patients with ischemic colitis: review of fifty-three cases", Dis Colon Rectum, 47, pp.180~184 (2004)
- O’Neill S, "Systematic review of the management of ischaemic colitis", Colorectal Dis, 14, pp.e751~e763 (2012)
- Lim YJ, "Clinical patterns and prognostic factors of ischemic colitis", Korean J Gastrointest Endosc, 22, pp.76~82 (2001)
- Flobert C, "Right colonic involvement is associated with severe forms of ischemic colitis and occurs frequently in patients with chronic renal failure requiring hemodialysis", Am J Gastroenterol, 95, pp.195~198 (2000)
- Zeier M, "Non-occlusive mesenteric infarction in dialysis patients: the importance of prevention and early intervention", Nephrol Dial Transplant, 10, pp.771~773 (1995)
- 안성은, "말기신질환이 중증의 허혈성 대장염의 위험인자인가?", 대한소화기학회지, 53(4), pp.235~238 (2009), 대한소화기학회
- Buccheri G, "Karnofsky and ECOG performance status scoring in lung cancer: a prospective, longitudinal study of 536 patients from a single institution", Eur J Cancer, 32A, pp.1135~1141 (1996)
- Corrêa GT, "Analysis of ECOG performance status in head and neck squamous cell carcinoma patients: association with sociodemographical and clinical factors, and overall survival", Support Care Cancer, 20, pp.2679~2685 (2012)
- Ström K, "Quality assessment and predictors of survival in long-term domiciliary oxygen therapy. The Swedish Society of Chest Medicine", Eur Respir J, 4, pp.50~58 (1991)
- St Julien JB, "Obesity increases operating room time for lobectomy in the society of thoracic surgeons database", Ann Thorac Surg, 94, pp.1841~1847 (2012)
- Chamogeorgakis T, "External validation of the modified Thoracoscore in a new thoracic surgery program: prediction of in-hospital mortality", Interact Cardiovasc Thorac Surg, 9, pp.463~466 (2009)
- Park CM, "Impact of Eastern Cooperative Oncology Group Performance Status on hospital mortality in critically ill patients", J Crit Care, 29, pp.409~413 (2014)