Drug-Induced Liver Injury: Pattern Recognition and Future Directions
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Drug-induced liver injury (DILI) remains a significant clinical challenge and is the leading cause of acute liver failure in most countries. An aging population that uses more medications, a constant influx of newly developed drugs and a growing risk from unfamiliar herbal and dietary supplements will make DILI an increasing part of clinical practice. Currently, the most effective strategy for disease management is rapid identification, withholding the inciting agents, supportive care and having a firm understanding of the expected natural history. There are resources available to aid the clinician, including a new online “textbook” as well as causality assessment tools, but a heightened awareness of risk and the disease’s varying phenotypes and good history-taking remain cornerstones to diagnosis. Looking ahead, growing registries of cases, pharmacoepidemiology studies and translational research into the mechanisms of injury may produce better diagnostic tools, markers for risk and disease, and prevention and therapeutics.
Abstract
Drug-induced liver injury (DILI) remains a significant clinical challenge and is the leading cause of acute liver failure in most countries. An aging population that uses more medications, a constant influx of newly developed drugs and a growing risk from unfamiliar herbal and dietary supplements will make DILI an increasing part of clinical practice. Currently, the most effective strategy for disease management is rapid identification, withholding the inciting agents, supportive care and having a firm understanding of the expected natural history. There are resources available to aid the clinician, including a new online “textbook” as well as causality assessment tools, but a heightened awareness of risk and the disease’s varying phenotypes and good history-taking remain cornerstones to diagnosis. Looking ahead, growing registries of cases, pharmacoepidemiology studies and translational research into the mechanisms of injury may produce better diagnostic tools, markers for risk and disease, and prevention and therapeutics.
참고문헌 (107)
- Ostapowicz G, "Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States", Ann Intern Med, 137, pp.947~954 (2002)
- Wilke RA, "Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges", Nat Rev Drug Discov, 6, pp.904~916 (2007)
- Björnsson ES, "Epidemiology and risk factors for idiosyncratic drug-induced liver injury", Semin Liver Dis, 34, pp.115~122 (2014)
- Sgro C, "Incidence of drug-induced hepatic injuries: a French population-based study", Hepatology, 36, pp.451~455 (2002)
- de Abajo FJ, "Acute and clinically relevant drug-induced liver injury: a population based case-control study", Br J Clin Pharmacol, 58, pp.71~80 (2004)
- Lee WM, "Recognizing drug-induced liver injury: current problems, possible solutions", Toxicol Pathol, 33, pp.155~164 (2005)
- Björnsson ES, "Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland", Gastroenterology, 144(e3), pp.1419~1425 (2013)
- Fountain FF, "Isoniazid hepatotoxicity associated with treatment of latent tuberculosis infection: a 7-year evaluation from a public health tuberculosis clinic", Chest, 128, pp.116~123 (2005)
- Olsson R, "Liver damage from flucloxacillin, cloxacillin and dicloxacillin", J Hepatol, 15, pp.154~161 (1992)
- Stock JG, "Unexplained hepatitis following halothane", Anesthesiology, 63, pp.424~439 (1985)
- Lucena MI, "Determinants of the clinical expression of amoxicillin-clavulanate hepatotoxicity: a prospective series from Spain", Hepatology, 44, pp.850~856 (2006)
- Stricker BH, "Hepatic injury associated with the use of nitrofurans: a clinicopathological study of 52 reported cases", Hepatology, 8, pp.599~606 (1988)
- Chalasani N, "Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States", Gastroenterology, 135(e4), pp.1924~1934 (2008)
- Chalasani NP, "ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury", Am J Gastroenterol, 109, pp.950~966 (2014)
- Morgan DJ, "Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease: an update", Clin Pharmacokinet, 29, pp.370~391 (1995)
- Lewis JH, "Review article: prescribing medications in patients with cirrhosis. A practical guide", Aliment Pharmacol Ther, 37, pp.1132~1156 (2013)
- Saukkonen JJ, "An official ATS statement: hepatotoxicity of antituberculosis therapy", Am J Respir Crit Care Med, 174, pp.935~952 (2006)
- Sulkowski MS, "Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy: role of hepatitis C and B infections", Hepatology, 35, pp.182~189 (2002)
- Russo MW, "Liver transplantation for acute liver failure from drug induced liver injury in the United States", Liver Transpl, 10, pp.1018~1023 (2004)
- Lucena MI, "Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex", Hepatology, 49, pp.2001~2009 (2009)
- Chen M, "High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury", Hepatology, 58, pp.388~396 (2013)
- Bénichou C, "Criteria of drug-induced liver disorders: report of an international consensus meeting", J Hepatol, 11, pp.272~276 (1990)
- Benichou C, "Causality assessment of adverse reactions to drugs: II. an original model for validation of drug causality assessment methods: case reports with positive rechallenge", J Clin Epidemiol, 46, pp.1331~1336 (1993)
- Chitturi S, "Schiff’s diseases of the liver", pp.703~783 (2012), Wiley-Blackwell
- Hennes EM, "Simplified criteria for the diagnosis of autoimmune hepatitis", Hepatology, 48, pp.169~176 (2008)
- Czaja AJ, "Corticosteroids or not in severe acute or fulminant autoimmune hepatitis: therapeutic brinksmanship and the point beyond salvation", Liver Transpl, 13, pp.953~955 (2007)
- Ichai P, "Usefulness of corticosteroids for the treatment of severe and fulminant forms of autoimmune hepatitis", Liver Transpl, 13, pp.996~1003 (2007)
- Danan G, "Causality assessment of adverse reactions to drugs: I. a novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries", J Clin Epidemiol, 46, pp.1323~1330 (1993)
- Maria VA, "Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis", Hepatology, 26, pp.664~669 (1997)
- Hayashi PH, "Clinical features, diagnosis, and natural history of drug-induced liver injury", Semin Liver Dis, 34, pp.134~144 (2014)
- Rochon J, "Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug-induced liver injury", Hepatology, 48, pp.1175~1183 (2008)
- Hoofnagle JH, "LiverTox: a website on drug-induced liver injury", Hepatology, 57, pp.873~874 (2013)
- "LiverTox" (2015)[URL]
- Temple R, "Hy’s law: predicting serious hepatotoxicity", Pharmacoepidemiol Drug Saf, 15, pp.241~243 (2006)
- Björnsson E, "Outcome and prognostic markers in severe drug-induced liver disease", Hepatology, 42, pp.481~489 (2005)
- Andrade RJ, "Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period", Gastroenterology, 129, pp.512~521 (2005)
- Bahirwani R, "Drug-induced liver injury due to cancer chemotherapeutic agents", Semin Liver Dis, 34, pp.162~171 (2014)
- Hicks LA, "U.S. outpatient antibiotic prescribing, 2010", N Engl J Med, 368, pp.1461~1462 (2013)
- Larrey D, "Hepatitis associated with amoxycillin-clavulanic acid combination report of 15 cases", Gut, 33, pp.368~371 (1992)
- García Rodríguez LA, "Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid", Arch Intern Med, 156, pp.1327~1332 (1996)
- Reddy KR, "Amoxicillin-clavulanate potassium-associated cholestasis", Gastroenterology, 96, pp.1135~1141 (1989)
- Richardet JP, "Prolonged cholestasis with ductopenia after administration of amoxicillin", clavulanic acid, 1999, pp.44, 1997~2000
- Eckstein RP, "Flucloxacillin induced liver disease: histopathological findings at biopsy and autopsy", Pathology, 25, pp.223~228 (1993)
- Peker E, "Ceftriaxone-induced toxic hepatitis", World J Gastroenterol, 15, pp.2669~2671 (2009)
- Metushi IG, "A fresh look at the mechanism of isoniazid-induced hepatotoxicity", Clin Pharmacol Ther, 89, pp.911~914 (2011)
- Tostmann A, "Antituberculosis drug-induced hepatotoxicity: concise up-to-date review", J Gastroenterol Hepatol, 23, pp.192~202 (2008)
- Sharma SK, "Safety of 3 different reintroduction regimens of antituberculosis drugs after development of antituberculosis treatment-induced hepatotoxicity", Clin Infect Dis, 50, pp.833~839 (2010)
- Tahaoğlu K, "The management of anti-tuberculosis drug-induced hepatotoxicity", Int J Tuberc Lung Dis, 5, pp.65~69 (2001)
- Durand F, "Deleterious influence of pyrazinamide on the outcome of patients with fulminant or subfulminant liver failure during antituberculous treatment including isoniazid", Hepatology, 21, pp.929~932 (1995)
- Mainra RR, "Trimethoprim-sulfamethoxazole-associated hepatotoxicity: part of a hypersensitivity syndrome", Can J Clin Pharmacol, 10, pp.175~178 (2003)
- Yao F, "Trimethoprim-sulfamethoxazole-induced vanishing bile duct syndrome", Am J Gastroenterol, 92, pp.167~169 (1997)
- García Rodríguez LA, "A cohort study on the risk of acute liver injury among users of ketoconazole and other antifungal drugs", Br J Clin Pharmacol, 48, pp.847~852 (1999)
- Stricker BH, "Ketoconazole-associated hepatic injury: a clinicopathological study of 55 cases", J Hepatol, 3, pp.399~406 (1986)
- Ikemoto H, "A clinical study of fluconazole for the treatment of deep mycoses", Diagn Microbiol Infect Dis, 12(4), pp.239S~247S (1989)
- Fischer MA, "The hepatotoxicity of antifungal medications in bone marrow transplant recipients", Clin Infect Dis, 41, pp.301~307 (2005)
- Núñez M, "Clinical syndromes and consequences of antiretroviral-related hepatotoxicity", Hepatology, 52, pp.1143~1155 (2010)
- Surgers L, "Hepatoxicity of new antiretrovirals: a systematic review", Clin Res Hepatol Gastroenterol, 37, pp.126~133 (2013)
- Sulkowski MS, "Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir", AIDS, 18, pp.2277~2284 (2004)
- Sulkowski MS, "Drug-induced liver injury associated with antiretroviral therapy that includes HIV-1 protease inhibitors", Clin Infect Dis, 38(2), pp.S90~S97 (2004)
- Eshki M, "Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure", Arch Dermatol, 145, pp.67~72 (2009)
- Mullick FG, "Hepatic injury associated with diphenylhydantoin therapy: a clinicopathologic study of 20 cases", Am J Clin Pathol, 74, pp.442~452 (1980)
- Zimmerman HJ, "Valproate-induced hepatic injury: analyses of 23 fatal cases", Hepatology, 2, pp.591~597 (1982)
- Lacroix I, "Nonsteroidal anti-inflammatory drug-induced liver injury: a case-control study in primary care", Fundam Clin Pharmacol, 18, pp.201~206 (2004)
- Johnson AG, "The problems and pitfalls of NSAID therapy in the elderly (Part I)", Drugs Aging, 1, pp.130~143 (1991)
- Manoukian AV, "Nonsteroidal anti-inflammatory drug-induced hepatic disorders: incidence and prevention", Drug Saf, 15, pp.64~71 (1996)
- Riley TR 3rd, "Ibuprofen-induced hepatotoxicity in patients with chronic hepatitis C: a case series", Am J Gastroenterol, 93, pp.1563~1565 (1998)
- Andrade RJ, "Chronic hepatitis C, ibuprofen, and liver damage", Am J Gastroenterol, 97, pp.1854~1855 (2002)
- Scully LJ, "Diclofenac induced hepatitis: 3 cases with features of autoimmune chronic active hepatitis", Dig Dis Sci, 38, pp.744~751 (1993)
- Daly AK, "Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes", Gastroenterology, 132, pp.272~281 (2007)
- Maddrey WC, "The hepatic safety and tolerability of the novel cyclooxygenase-2 inhibitor celecoxib", Am J Ther, 7, pp.153~158 (2000)
- El Hajj I, "Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation", World J Gastroenterol, 15, pp.3937~3939 (2009)
- Tolman KG, "Defining patient risks from expanded preventive therapies", Am J Cardiol, 85, pp.15E~19E (2000)
- McKenney JM, "National Lipid Association Statin Safety Assessment Task Force. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force", Am J Cardiol, 97, pp.89C~94C (2006)
- Lewis JH, "Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial", Hepatology, 46, pp.1453~1463 (2007)
- Avins AL, "Hepatic effects of lovastatin exposure in patients with liver disease: a retrospective cohort study", Drug Saf, 31, pp.325~334 (2008)
- Grimbert S, "Acute hepatitis induced by HMG-CoA reductase inhibitor, lovastatin", Dig Dis Sci, 39, pp.2032~2033 (1994)
- Hartleb M, "Acute cholestatic hepatitis associated with pravastatin", Am J Gastroenterol, 94, pp.1388~1390 (1999)
- Pelli N, "Autoimmune hepatitis revealed by atorvastatin", Eur J Gastroenterol Hepatol, 15, pp.921~924 (2003)
- Tolman KG, "The liver and lovastatin", Am J Cardiol, 89, pp.1374~1380 (2002)
- Di Bisceglie AM, "Recent US Food and Drug Administration warnings on hepatitis B reactivation with immune-suppressing and anticancer drugs: just the tip of the iceberg?", Hepatology, 61, pp.703~711 (2015)
- Lok AS, "Chronic hepatitis B: update 2009", Hepatology, 50, pp.661~662 (2009)
- Ghabril M, "Liver injury from tumor necrosis factor-alpha antagonists: analysis of thirty-four cases", Clin Gastroenterol Hepatol, 11(e3), pp.558~564 (2013)
- Becker H, "Etanercept tolerance in a patient with previous infliximab-induced hepatitis", Clin Rheumatol, 27, pp.1597~1598 (2008)
- Thiéfin G, "Infliximab-induced hepatitis: absence of cross-toxicity with etanercept", Joint Bone Spine, 75, pp.737~739 (2008)
- Parekh R, "Liver injury secondary to anti-TNF-alpha therapy in inflammatory bowel disease: a case series and review of the literature", Case Rep Gastrointest Med, 2014, pp.956463~ (2014)
- Bailey RL, "Dietary supplement use in the United States, 2003-2006", J Nutr, 141, pp.261~266 (2011)
- Navarro VJ, "Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network", Hepatology, 60, pp.1399~1408 (2014)
- Navarro VJ, "Hepatotoxicity induced by herbal and dietary supplements", Semin Liver Dis, 34, pp.172~193 (2014)
- Bunchorntavakul C, "Review article: herbal and dietary supplement hepatotoxicity", Aliment Pharmacol Ther, 37, pp.3~17 (2013)
- Skoulidis F, "Ma huang associated acute liver failure requiring liver transplantation", Eur J Gastroenterol Hepatol, 17, pp.581~584 (2005)
- Neff GW, "Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid", J Hepatol, 41, pp.1062~1064 (2004)
- "FDA issues regulation prohibiting sale of dietary supplements containing ephedrine alkaloids and reiterates its advice that consumers stop using these products" (2004)[URL]
- Navarro VJ, "Catechins in dietary supplements and hepatotoxicity", Dig Dis Sci, 58, pp.2682~2690 (2013)
- Bonkovsky HL, "Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis)", Ann Intern Med, 144, pp.68~71 (2006)
- Javaid A, "Hepatotoxicity due to extracts of Chinese green tea (Camellia sinensis): a growing concern", J Hepatol, 45, pp.334~335 (2006)
- Vanstraelen S, "Jaundice as a misadventure of a green tea (camellia sinensis) lover: a case report", Acta Gastroenterol Belg, pp.409~412 (2008)
- Dara L, "Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements", World J Gastroenterol, 14, pp.6999~7004 (2008)
- Singh V, "Severe hepatotoxicity caused by a methasteron-containing performance-enhancing supplement", J Clin Gastroenterol, 43, pp.287~ (2009)
- Martin DJ, "Hepatotoxicity associated with the dietary supplement N.O.-XPLODE", Ann Intern Med, 159, pp.503~504 (2013)
- Glober GA, "Biliary cirrhosis following the administration of methyltestosterone", JAMA, 204, pp.170~173 (1968)
- Westaby D, "Androgen related primary hepatic tumors in non-Fanconi patients", Cancer, 51, pp.1947~1952 (1983)
- Monshi MM, "Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury", Hepatology, 57, pp.727~739 (2013)
- Chung WH, "Medical genetics: a marker for Stevens-Johnson syndrome", Nature, 428, pp.486~ (2004)
- Sharma SK, "Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment", Am J Respir Crit Care Med, 166, pp.916~919 (2002)
- Martin AM, "Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts", AIDS, 19, pp.97~99 (2005)
- Urban TJ, "Genetic basis of drug-induced liver injury: present and future", Semin Liver Dis, 34, pp.123~133 (2014)
- Bamshad MJ, "Exome sequencing as a tool for Mendelian disease gene discovery", Nat Rev Genet, 12, pp.745~755 (2011)
