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Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm

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Background/Aims: To identify the risk factors for metachronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. Methods: We prospectively collected clinicopathologic data and measured the methylation levels of HAND1, THBD, APC, and MOS in the gastric mucosa by methylation-specific real-time polymerase chain reaction in patients who underwent endoscopic resection of gastric neoplasms. Results: A total of 257 patients with gastric neoplasms (113 low-grade dysplasias, 25 highgrade dysplasias, and 119 early gastric cancers) were enrolled. Metachronous gastric neoplasm developed in 7.4% of patients during a mean follow-up of 52 months. The 5-year cumulative incidence of metachronous gastric neoplasm was 4.8%. Multivariate analysis showed that moderate/severe corpus intestinal metaplasia and family history of gastric cancer were independent risk factors for metachronous gastric neoplasm development; the hazard ratios were 4.12 (95% confidence interval [CI], 1.23 to 13.87; p=0.022) and 3.52 (95% CI, 1.09 to 11.40; p=0.036), respectively. The methylation level of MOS was significantly elevated in patients with metachronous gastric neoplasms compared age- and sexmatched patients without metachronous gastric neoplasms (p=0.020). Conclusions: In patients who underwent endoscopic resection of gastric neoplasms, moderate/severe corpus intestinal metaplasia and a family history of gastric cancer were independent risk factors for metachronous gastric neoplasm, and MOS was significantly hypermethylated in patients with metachronous gastric neoplasms.

Abstract

Background/Aims: To identify the risk factors for metachronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. Methods: We prospectively collected clinicopathologic data and measured the methylation levels of HAND1, THBD, APC, and MOS in the gastric mucosa by methylation-specific real-time polymerase chain reaction in patients who underwent endoscopic resection of gastric neoplasms. Results: A total of 257 patients with gastric neoplasms (113 low-grade dysplasias, 25 highgrade dysplasias, and 119 early gastric cancers) were enrolled. Metachronous gastric neoplasm developed in 7.4% of patients during a mean follow-up of 52 months. The 5-year cumulative incidence of metachronous gastric neoplasm was 4.8%. Multivariate analysis showed that moderate/severe corpus intestinal metaplasia and family history of gastric cancer were independent risk factors for metachronous gastric neoplasm development; the hazard ratios were 4.12 (95% confidence interval [CI], 1.23 to 13.87; p=0.022) and 3.52 (95% CI, 1.09 to 11.40; p=0.036), respectively. The methylation level of MOS was significantly elevated in patients with metachronous gastric neoplasms compared age- and sexmatched patients without metachronous gastric neoplasms (p=0.020). Conclusions: In patients who underwent endoscopic resection of gastric neoplasms, moderate/severe corpus intestinal metaplasia and a family history of gastric cancer were independent risk factors for metachronous gastric neoplasm, and MOS was significantly hypermethylated in patients with metachronous gastric neoplasms.

참고문헌 (35)

  1. Nakajima T, "Metachronous gastric cancers after endoscopic resection: how effective is annual endoscopic surveillance?", Gastric Cancer, 9, pp.93~98 (2006)
  2. Kato M, "Scheduled endoscopic surveillance controls secondary cancer after curative endoscopic resection for early gastric cancer: a multicentre retrospective cohort study by Osaka University ESD study group", Gut, 62, pp.1425~1432 (2013)
  3. Hanaoka N, "Autofluorescence imaging for predicting development of metachronous gastric cancer after Helicobacter pylori eradication", J Gastroenterol Hepatol, 25, pp.1844~1849 (2010)
  4. Watari J, "Biomarkers predicting development of metachronous gastric cancer after endoscopic resection:an analysis of molecular pathology of Helicobacter pylori eradication", Int J Cancer, 130, pp.2349~2358 (2012)
  5. Kim YI, "The association between Helicobacter pylori status and incidence of metachronous gastric cancer after endoscopic resection of early gastric cancer", Helicobacter, 19, pp.194~201 (2014)
  6. Ushijima T, "Molecular pathways: involvement of Helicobacter pylori-triggered inflammation in the formation of an epigenetic field defect, and its usefulness as cancer risk and exposure markers", Clin Cancer Res, 18, pp.923~929 (2012)
  7. Chiba T, "Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation", Gastroenterology, 143, pp.550~563 (2012)
  8. Graham DY, "Helicobacter pylori eradication and metachronous gastric cancer", Clin Gastroenterol Hepatol, 12, pp.801~803 (2014)
  9. Yoon H, "Effect of endoscopic screening at 1-year intervals on the clinicopathologic characteristics and treatment of gastric cancer in South Korea", J Gastroenterol Hepatol, 27, pp.928~934 (2012)
  10. Shin CM, "Role of Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis", Cancer Sci, 101, pp.1337~1346 (2010)
  11. Shin CM, "Genome-wide DNA methylation profiles in noncancerous gastric mucosae with regard to Helicobacter pylori infection and the presence of gastric cancer", Helicobacter, 16, pp.179~188 (2011)
  12. Shin CM, "Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae", J Pathol, 226, pp.654~665 (2012)
  13. Shin CM, "Changes in aberrant DNA methylation after Helicobacter pylori eradication: a long-term follow-up study", Int J Cancer, 133, pp.2034~2042 (2013)
  14. Soetikno R, "Endoscopic mucosal resection for early cancers of the upper gastrointestinal tract", J Clin Oncol, 23, pp.4490~4498 (2005)
  15. Shin CM, "Validation of diagnostic tests for Helicobacter pylori with regard to grade of atrophic gastritis and", or intestinal metaplasia, 2009, pp.14, 512~519
  16. Yoon H, "Helicobacter pylori-negative gastric cancer in South Korea: incidence and clinicopathologic characteristics", Helicobacter, 16, pp.382~388 (2011)
  17. Miki K, "The significance of low serum pepsinogen levels to detect stomach cancer associated with extensive chronic gastritis in Japanese subjects", Jpn J Cancer Res, 80, pp.111~114 (1989)
  18. Dixon MF, "Classification and grading of gastritis: the updated Sydney System. International workshop on the histopathology of gastritis, Houston 1994", Am J Surg Pathol, 20, pp.1161~1181 (1996)
  19. Yoon H, "Risk factors of residual or recurrent tumor in patients with a tumor-positive resection margin after endoscopic resection of early gastric cancer", Surg Endosc, 27, pp.1561~1568 (2013)
  20. Herman JG, "Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands", Proc Natl Acad Sci U S A, 93, pp.9821~9826 (1996)
  21. Leung WK, "Review article: intestinal metaplasia and gastric carcinogenesis", Aliment Pharmacol Ther, 16, pp.1209~1216 (2002)
  22. Kim N, "Helicobacter pylori infection and development of gastric cancer in Korea: long-term follow-up", J Clin Gastroenterol, 42, pp.448~454 (2008)
  23. You WC, "Evolution of precancerous lesions in a rural Chinese population at high risk of gastric cancer", Int J Cancer, 83, pp.615~619 (1999)
  24. Cassaro M, "Topographic patterns of intestinal metaplasia and gastric cancer", Am J Gastroenterol, 95, pp.1431~1438 (2000)
  25. Bae SE, "Effect of Helicobacter pylori eradication on metachronous recurrence after endoscopic resection of gastric neoplasm", Am J Gastroenterol, 109, pp.60~67 (2014)
  26. 장미영, "Clinicopathological characteristics of synchronous and metachronous gastric neoplasms after endoscopic submucosal dissection", The Korean Journal of Internal Medicine, 28(6), pp.687~693 (2013), 대한내과학회[DOI]
  27. Han JS, "A study of metachronous cancer after endoscopic resection of early gastric cancer", Scand J Gastroenterol, 46, pp.1099~1104 (2011)
  28. Kim N, "Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease", Helicobacter, 13, pp.245~255 (2008)
  29. Lee IS, "Multiple synchronous early gastric cancers: high-risk group and proper management", Surg Oncol, 21, pp.269~273 (2012)
  30. Shin CM, "Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer", J Clin Gastroenterol, 44, pp.e34~e39 (2010)
  31. Brenner H, "Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma", Cancer, 88, pp.274~279 (2000)
  32. Eshmuratov A, "The correlation of endoscopic and histological diagnosis of gastric atrophy", Dig Dis Sci, 55, pp.1364~1375 (2010)
  33. Toshikazu Ushijima, "Epigenetic Field for Cancerization", BMB reports, 40(2), pp.142~150 (2007), 한국생화학분자생물학회
  34. 강정묵, "CDX1 and CDX2 Expression in Intestinal Metaplasia, Dysplasia and Gastric Cancer", Journal of Korean Medical Science, 26(5), pp.647~653 (2011), 대한의학회
  35. Byoung Hwan Lee, "The Role of CDX2 in Intestinal Metaplasia Evaluated Using Immunohistochemistry", Gut and Liver, 6(1), pp.71~77 (2012), 거트앤리버 발행위원회

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