아토피피부염의 중증도와 심박변이도의 상관성 연구
The Correlation between Atopic Dermatitis Severity and Heart Rate Variability
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Background : There are findings indicating that the autonomic nervous system (ANS) is affected negatively in atopic dermatitis (AD). Heart rate variability (HRV) is a tool to examine ANS. But, studies investigation the relationship between AD and HRV is rare. Objective : The aim of this study was to investigate the correlation between atopic dermatitis severity and HRV and to find out the role of ANS in AD. Methods : Retrospective chart review was performed. The Severity Scoring Atopic Dermatitis (SCORAD) index and HRV parameter was investigated and analyzed. Results : There were 55 patients (25males and 30 females) who met the criteria. Objective SCORAD had significant positive correlation with HRT and Subjective SCORAD had significant negative correlation with SDNN, TP and VLF. Intensity item of SCORAD index had negative correlation with most HRV parameters, but TP, LF and LF/HF ratio had significant positive correlation with dryness. Conclusion : This study supports the concept that atopic dermatitis is a stress-responsive disorder and involves autonomic nervous system dysfunction.
Abstract
Background : There are findings indicating that the autonomic nervous system (ANS) is affected negatively in atopic dermatitis (AD). Heart rate variability (HRV) is a tool to examine ANS. But, studies investigation the relationship between AD and HRV is rare. Objective : The aim of this study was to investigate the correlation between atopic dermatitis severity and HRV and to find out the role of ANS in AD. Methods : Retrospective chart review was performed. The Severity Scoring Atopic Dermatitis (SCORAD) index and HRV parameter was investigated and analyzed. Results : There were 55 patients (25males and 30 females) who met the criteria. Objective SCORAD had significant positive correlation with HRT and Subjective SCORAD had significant negative correlation with SDNN, TP and VLF. Intensity item of SCORAD index had negative correlation with most HRV parameters, but TP, LF and LF/HF ratio had significant positive correlation with dryness. Conclusion : This study supports the concept that atopic dermatitis is a stress-responsive disorder and involves autonomic nervous system dysfunction.
참고문헌 (24)
- Stander S, "Pathophysiology of pruritus in atopic dermatitis: an overview", Exp Dermatol, 11(1), pp.12~24 (2002)
- Kirchner A, "Influence of vagus nerve stimulation on histamine-induced itching", Neurology, 59(1), pp.108~112 (2002)
- Hassett AL, "pilot study of the efficacy of heart rate variability biofeedback in patients with fibromyalgia", Appl Psychophysiol Biofeedback, 32(1), pp.1~10 (2007)
- Dobrek L, "Autonomic nervous system activity in IBS patients estimated by heart rate variability", Przegl Lek, 63(9), pp.743~747 (2006)
- 김지은, "건강인의 표리 한열 변증, HRV, 우울, 불안 지표의 상관성 분석", 동의생리병리학회지, 20(2), pp.482~487 (2006), 대한동의병리학회
- Kemp AH, "Impact of Depression and antidepressant treatment on heart rate variability: a review and meta-analysis", Biol Psychiatry, 67(11), pp.1067~1074 (2010)
- Yokusoglu M, "Heart rate variability in patients with allergic rhinitis", Mil Med, 172(1), pp.98~101 (2007)
- Tokuyama K, "Beat-to-beat variation of the heart rate in children with allergic asthma", J Asthma, 22(6), pp.285~288 (1985)
- Markuszeski L, "Heart rate and arrhythmia in patients with psoriasis vulgaris", Arch Med Res, 38(1), pp.64~69 (2007)
- Seiffert K, "Psychophysiological reactivity under mental stress in atopic dermatitis", Dermatology, 210(4), pp.286~293 (2005)
- Tran BW, "Effect of Itch, Scratching and Mental Stress on Autonomic Nervous System Function in Atopic Dermatitis", Acta Derm Venereol, 90(4), pp.354~361 (2010)
- Hanifin JM, "Diagnostic features of atopic dermatitis", Derm Venereal (Stockh)(suppl.), 92, pp.44~47 (1980)
- Kunz B, "Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis", Dermatology, 195(1), pp.10~19 (1997)
- Hashizume H, "Anxiety accelerates T-helper 2-tilted immune responses in patients with atopic dermatitis", Br J Dermatol, 152(6), pp.1161~1164 (2005)
- Shahabi S, "Sympathetic nervous system plays an important role in the relationship between immune mediated diseases", Med Hypotheses, 67(4), pp.900~903 (2006)
- Cicek D, "Does autonomic dysfunction play a role in atopic dermatitis", Br J Dermatol, 159(4), pp.834~838 (2008)
- Yosipovitch G, "Chronic itch and chronic pain: analogous mechanisms pain", 131, pp.4~7 (2007)
- Yosipovitch G, "What causes itch in atopic dermatitis", Curr Allergy Asthma Rep, 8(4), pp.306~311 (2008)
- Biró T, "How best to fight that nasty itch –. from new insights into the neuroimmunological, neuroendocrine, and neurophysiological basis of pruritus to novel therapeutic approaches", Exp Dermatol, 14(3), pp.225~240 (2005)
- Boettger MK, "Increased vagal modulation in atopic dermatitis", J Dermatol Sci, 53(1), pp.55~59 (2009)
- Yang HJ, "Evaluation of patient's subjective severity using various scoring system in Korean children with atopic dermatitis", Asian Pac J Allergy Immunol, 28(2), pp.130~135 (2010)
- "Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation, and clinical use", Circulation, 98, pp.1043~1065 (1996)
- 전국한의과대학 진단 생기능의학교실, "생기능의학", pp.81~101 (2008), 군자출판사
- Acharya U R, "Heart rate analysis in normal subjects of various age groups", Biomed Eng Online, 3(1), pp.24~ (2004)