Distal Cholangiocarcinoma with Gastric Metastasis Mimicking Early Gastric Cancer
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We report an unusual case of distal cholangiocarcinoma with gastric metastasis mimicking early gastric cancer. A 67-year-old woman presented with a 4- month history of abdominal pain after eating. Computed tomography showed a malignant tumor of the common bile duct located just above the intrapancreatic segment, and endoscopy revealed a 2-cm, flat, elevated lesion with convergence of the surrounding folds, situated at the gastric angle. Based on the endoscopic biopsy results, an adenocarcinoma, thought to be an early gastric cancer, was diagnosed. The patient underwent Whipples’s operation. Histopathological findings showed that the adenocarcinomatous tissue was clearly demarcated and infiltrated the gastric mucosa and submucosa, leaving the gastric superficial mucosa intact. Both tumors showed similar pathological features and were positive for cytokeratin (CK)-19 and CK-7. These finding suggest distal cholangiocarcinoma with gastric metastasis.
Abstract
We report an unusual case of distal cholangiocarcinoma with gastric metastasis mimicking early gastric cancer. A 67-year-old woman presented with a 4- month history of abdominal pain after eating. Computed tomography showed a malignant tumor of the common bile duct located just above the intrapancreatic segment, and endoscopy revealed a 2-cm, flat, elevated lesion with convergence of the surrounding folds, situated at the gastric angle. Based on the endoscopic biopsy results, an adenocarcinoma, thought to be an early gastric cancer, was diagnosed. The patient underwent Whipples’s operation. Histopathological findings showed that the adenocarcinomatous tissue was clearly demarcated and infiltrated the gastric mucosa and submucosa, leaving the gastric superficial mucosa intact. Both tumors showed similar pathological features and were positive for cytokeratin (CK)-19 and CK-7. These finding suggest distal cholangiocarcinoma with gastric metastasis.
참고문헌 (15)
- Shaib Y, "The epidemiology of cholangiocarcinoma", Semin Liver Dis, 24, pp.115~125 (2004)
- Wakahara T, "Metastatic colon cancer from intrahepatic cholangiocarcinoma", J Hepatobiliary Pancreat Surg, 12, pp.415~418 (2005)
- De Palma GD, "Metastatic tumors to the stomach: clinical and endoscopic features", World J Gastroenterol, 12, pp.7326~7328 (2006)
- Stroescu C, "The diagnostic value of cytokeratins and carcinoembryonic antigen immunostaining in differentiating hepatocellular carcinomas from intrahepatic cholangiocarcinomas", J Gastrointestin Liver Dis, 15, pp.999~14 (2006)
- Lee MJ, "Expression of mucins and cytokeratins in primary carcinomas of the digestive system", Mod Pathol, 16, pp.403~410 (2003)
- Fidler IJ, "The implications of angiogenesis for the biology and therapy of cancer metastasis", Cell, 79, pp.185~188 (1994)
- Park SY, "Panels of immunohistochemical markers help determine primary sites of metastatic adenocarcinoma", Arch Pathol Lab Med, 131, pp.1561~1567 (2007)
- Pandey D, "Adrenal metastasis from intrahepatic cholangiocarcinoma", Liver Int, 27, pp.1016~ (2007)
- Miyamoto J, "Metastatic skull tumor from cholangiocarcinoma", Neurol Med Chir, 47, pp.132~135 (2007)
- Bennett VS, "Cholangiocarcinoma presenting as a solitary epididymal metastasis: a case report and review of the literature", Diagn Pathol, 2, pp.33~ (2007)
- Yao X, "Transplanted corneal graft with metastatic cholangiocarcinoma to the donor eye", Eye Contact Lens, 34, pp.340~342 (2008)
- Okamura Y, "Carcinomatous meningitis secondary to cholangiocarcinoma without othersystemic metastasis", J Hepatobiliary Pancreat Surg, 5, pp.237~239 (2008)
- Khunamornpong S, "Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases", Int J Gynecol Pathol, 27, pp.366~379 (2008)
- Kwon OS, "Distant skeletal muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome", World J Gastroenterol, 3, pp.3141~3143 (2007)
- Stergiopoulos C, "Distant cutaneous metastasis preceding the diagnosis of ductal cholangiocarcinoma", J Eur Acad Dermatol Venereol, 23, pp.242~243 (2009)