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Liver Cirrhosis Induced by Porphyria Cutanea Tarda: A Case Report and Review

이홍식|김창덕|진윤태|현종진|엄순호|유호상|Hyung Joon Yim|Yeon Seok Seo|전훈재|Bora Keum|Kwang Gyun Lee
거트앤리버 소화기연관학회협의회|2010.12|Gut and Liver|제4권 제4호|pp. 551-555

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참고문헌

초록

Porphyria cutanea tarda (PCT) is a metabolic disorder that results in a decrease in uroporphyrinogen decarboxylase activity. It is characterized by photosensitivity,bullae formation, and skin pigmentation. There are four types of PCT: acquired, familial, toxic,and hepatoerythropoietic. Uroporphyrin levels are elevated in the urine of PCT patients. PCT can be differentiated from other porphyrias by its clinical characteristics and the porphyrin levels in the serum, erythrocytes,urine, and feces. This metabolic disorder can lead to liver dysfunction as well as histological changes such as fatty infiltration or hepatic fibrosis. PCT rarely manifests as liver cirrhosis. We report herein a case of PCT-induced liver cirrhosis that progressed to hepatic failure.

Abstract

Porphyria cutanea tarda (PCT) is a metabolic disorder that results in a decrease in uroporphyrinogen decarboxylase activity. It is characterized by photosensitivity,bullae formation, and skin pigmentation. There are four types of PCT: acquired, familial, toxic,and hepatoerythropoietic. Uroporphyrin levels are elevated in the urine of PCT patients. PCT can be differentiated from other porphyrias by its clinical characteristics and the porphyrin levels in the serum, erythrocytes,urine, and feces. This metabolic disorder can lead to liver dysfunction as well as histological changes such as fatty infiltration or hepatic fibrosis. PCT rarely manifests as liver cirrhosis. We report herein a case of PCT-induced liver cirrhosis that progressed to hepatic failure.

참고문헌 (31)

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