The Relationship between Quiescent Infl ammatory Bowel Disease and Peripheral Polyneuropathy
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Background/Aims: Infl ammatory bowel disease is a chronic,recurrent disorder that involves multiple organ systems. Polyneuropathy is the most common neurological manifestation. The aim of the present study was to investigate the relationship between polyneuropathy and infl ammatory bowel disease. Methods: The study included 40 patients with infl ammatory bowel disease (20 with ulcerative colitis and 20with Crohn’s disease) and 24 healthy controls. The patients had no clinical signs or symptoms of polyneuropathy. Nerve conduction studies were performed using an electroneuromyography apparatus. Results: Mean distal motor latencies,conduction velocities, and F wave minimum latencies of the right median nerve were signifi cantly abnormal in the patient group, compared to the healthy controls (p<0.05). Conclusions:Some electrophysiological alterations were observed in chronic infl ammatory bowel disease patients who showed no clinical signs. While investigating extra-intestinal manifestations in inflammatory bowel disease patients, nerve conduction studies must be performed to identify electrophysiological changes and subclinical peripheral polyneuropathy,which can subsequently develop.
Abstract
Background/Aims: Infl ammatory bowel disease is a chronic,recurrent disorder that involves multiple organ systems. Polyneuropathy is the most common neurological manifestation. The aim of the present study was to investigate the relationship between polyneuropathy and infl ammatory bowel disease. Methods: The study included 40 patients with infl ammatory bowel disease (20 with ulcerative colitis and 20with Crohn’s disease) and 24 healthy controls. The patients had no clinical signs or symptoms of polyneuropathy. Nerve conduction studies were performed using an electroneuromyography apparatus. Results: Mean distal motor latencies,conduction velocities, and F wave minimum latencies of the right median nerve were signifi cantly abnormal in the patient group, compared to the healthy controls (p<0.05). Conclusions:Some electrophysiological alterations were observed in chronic infl ammatory bowel disease patients who showed no clinical signs. While investigating extra-intestinal manifestations in inflammatory bowel disease patients, nerve conduction studies must be performed to identify electrophysiological changes and subclinical peripheral polyneuropathy,which can subsequently develop.
참고문헌 (15)
- diagnosis, "Crohn’s disease, In Gastrointestinal and liver disease: pathophysiology", pp.Saunders, management. Vol. 2. 7th ed
- diagnosis, "Ulcerative colitis, In Gastrointestinal and liver disease: pathophysiology", pp.Saunders, management. Vol. 2. 7th ed
- Travis S, "Ulcerative colitis: clinical presentation and diagnosis, In Inflammatory boweldisease", pp.169~182 (2003), Churchill Livingstone
- Papadakis KA, "Diagnosis and misdiagnosis of inflammatory bowel disease", Gastrointest Endosc Clin N Am, 12, pp.433~449 (2002)
- Ståhlberg D, "Neurophysiologic studies of patients with Crohn’s disease on long-term treatment with metronidazole", Scand J Gastroenterol, 26, pp.219~224 (1991)
- Adams RD, "Diseases of spinal cord, peripheral nerve, and muscle, In Principles of neurology. 6th ed", pp.1302~1370 (1997), Mc Graw-Hill
- Bosch EP, "of peripheral nerves, In Neurology in clinical practice. Vol. 2. 3th ed", pp.2045~2127 (2000), Butterworth-Heinemann
- Bromberg MB, "Handbook of peripheral neuropathy" (2005), Taylor & Francis
- "Peripheral neuropathy: new concepts and treatments", Neurol Clin, 10, pp.601~807 (1992)
- Gondim FA, "Peripheral neuropathy in patients with inflammatory bowel disease", Brain, 128(Pt 4), pp.867~879 (2005)
- Lossos A, "Neurologic aspects of inflammatory bowel disease", Neurology, 45(3 Pt 1), pp.416~421 (1995)
- Elsehety A, "Neurologic and neuropsychiatric complications of Crohn’s disease", South Med J, 90, pp.606~610 (1997)
- Oliveira GR, "Peripheral neuropathy and neurological disorders in an unselected Brazilian population-based cohort of IBD patients", Inflamm Bowel Dis, 14, pp.389~395 (2008)
- Gondim FA, "Peripheral neuropathy in patients with inflammatory bowel disease", Brain, 128(Pt 4), pp.867~879 (2005)
- Scheid R, "Neurologic manifestations of ulcerative colitis", Eur J Neurol, 14, pp.483~493 (2007)