The Clinical and Laboratory Characteristics of Patients with Chronic Hepatitis B Using Current or Past Antiviral Therapy in Korea: A Multi-Center, Nation-Wide, Cross-Sectional Epidemiologic Study
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Background/Aims: The proper assessment of the current disease status of patients with chronic hepatitis B would be valuable for establishing optimal management strategies. Methods: The clinical and laboratory characteristics of 2,954 patients with current or previous antiviral treatment (46.2±10.8 years, 69.7% male) enrolled from 46 referral hospitals and 129 local hospitals or clinics throughout Korea were analyzed. Results: The disease status included chronic hepatitis, cirrhosis, and hepatocellular carcinoma in 79.9%, 16.4%, and 3.7% of the patients, respectively. The major mode of hepatitis B virus (HBV) infection was vertical transmission. The hepatitis C virus (HCV) co-infection rate was 1.5%; however, only 50.8% of patients were evaluated for HCV. The use of herbal or complementary medicines was reported in 33.5% of the patients. The majority of patients (97.6%) were treated with oral nucleoside/nucleotide analogues. Several characteristics were different between the patients treated at referral hospitals and local hospitals/clinics, including the disease state, choice of antiviral drug,and methods of HBV DNA measurement. Conclusions: This study provides a comprehensive picture of the clinical and laboratory characteristics of patients treated in Korea. Efforts to optimize management strategies are warranted.
Abstract
Background/Aims: The proper assessment of the current disease status of patients with chronic hepatitis B would be valuable for establishing optimal management strategies. Methods: The clinical and laboratory characteristics of 2,954 patients with current or previous antiviral treatment (46.2±10.8 years, 69.7% male) enrolled from 46 referral hospitals and 129 local hospitals or clinics throughout Korea were analyzed. Results: The disease status included chronic hepatitis, cirrhosis, and hepatocellular carcinoma in 79.9%, 16.4%, and 3.7% of the patients, respectively. The major mode of hepatitis B virus (HBV) infection was vertical transmission. The hepatitis C virus (HCV) co-infection rate was 1.5%; however, only 50.8% of patients were evaluated for HCV. The use of herbal or complementary medicines was reported in 33.5% of the patients. The majority of patients (97.6%) were treated with oral nucleoside/nucleotide analogues. Several characteristics were different between the patients treated at referral hospitals and local hospitals/clinics, including the disease state, choice of antiviral drug,and methods of HBV DNA measurement. Conclusions: This study provides a comprehensive picture of the clinical and laboratory characteristics of patients treated in Korea. Efforts to optimize management strategies are warranted.
참고문헌 (22)
- Chae HB, "Current status of liver diseases in Korea: hepatitis B", Korean J Hepatol, 15(Suppl 6), pp.S13~S24 (2009)
- Sung JL, "Hepatitis B virus eradication strategy for Asia. The Asian Regional Study Group", Vaccine, 8(Suppl), pp.S95~S99 (1990)
- 최병호, "한국 소아 B형 간염의 역학과 현황", Korean Journal of Pediatrics, 51(7), pp.696~703 (2008), 대한소아과학회
- Duk-HeeLee, "Epidemiological Findings of Hepatitis B Infection Based on 1998 National Health and Nutrition Survey in Korea", Journal of Korean Medical Science, 17(4), pp.457~462 (2002), 대한의학회
- Bo Moon Shin, "Seroprevalence of Hepatitis B Virus among Health Care Workers in Korea", Journal of Korean Medical Science, 21(1), pp.58~62 (2006), 대한의학회
- Lee MS, "Hepatitis B vaccination and reduced risk of primary liver cancer among male adults: a cohort study in Korea", Int J Epidemiol, 27, pp.316~319 (1998)
- Lee KS, "Management of chronic hepatitis B", Korean J Hepatol, 13, pp.447~488 (2007)
- Korean Liver Cancer Study Group, "Practice guidelines for management of hepatocellular carcinoma 2009", Korean J Hepatol, 15, pp.391~423 (2009)
- Kwon SY, "Epidemiology and prevention of hepatitis B virus infection", Korean J Hepatol, 17, pp.87~95 (2011)
- Lavanchy D, "Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures", J Viral Hepat, 11, pp.97~107 (2004)
- Yun H, "High prevalence of HBV and HCV infection among intravenous drug users in Korea", J Med Virol, 80, pp.1570~1575 (2008)
- Kang J, "High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies", Ann Hematol, 90, pp.159~164 (2011)
- Lok AS, "Chronic hepatitis B", Hepatology, 45, pp.507~539 (2007)
- Feldman MS, "Sleisenger and Fordtran’s gastrointestinal and liver disease: pathology, diagnosis, management. 8th ed" (2006), Saunders
- Marcellin P, "High rate of adefovirlamivudine combination therapy in nucleoside-naïve patients with chronic hepatitis B in France: results of a national survey in 1730 patients", Eur J Gastroenterol Hepatol, 22, pp.1290~1296 (2010)
- 임형준, "Evolution of multi-drug resistant hepatitis B virus during sequential therapy", HEPATOLOGY, 44(3), pp.703~712, JOHN WILEY SONS INC
- Yim HJ, "Natural history of chronic hepatitis B virus infection: what we knew in 1981 and what we know in 2005", Hepatology, 43(2 Suppl 1), pp.S173~S181 (2006)
- Hadziyannis SJ, "Hepatitis B e antigen-negative chronic hepatitis B", Hepatology, 34(4 Pt 1), pp.617~624 (2001)
- 최문석, "Management of Chronic Hepatitis B with Nucleoside or Nucleotide Analogues: A Review of Current Guidelines", Gut and Liver, 4(1), pp.15~24 (2010), 거트앤리버 발행위원회
- Pawlotsky JM, "Molecular diagnosis of viral hepatitis", Gastroenterology, 122, pp.1554~1568 (2002)
- European Association for the Study of the Liver, "EASL Clinical Practice Guidelines: management of chronic hepatitis B", J Hepatol, 50, pp.227~242 (2009)
- Lok AS, "Chronic hepatitis B: update 2009", Hepatology, 50, pp.661~662 (2009)