The Relationship between Gastroesophageal Reflux Disease and Chronic Periodontitis
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Background/Aims: The most common cause of chronic periodontitis is poor oral hygiene. Gastroesophageal reflux disease (GERD) enhances the proximal migration of gastric contents and may cause poor oral hygiene. We hypothesized that GERD may increase thse risk of chronic periodontitis and investigated this potential relationship. Methods: A retrospective cross-sectional study was conducted in outpatients between January 1, 2010, and April 30, 2012. GERD was defined as being present based on at least two of the following criteria: etiologic agent(s), identifiable signs and symptoms, and consistent anatomic alterations. A total of 280 patients with chronic periodontitis and 280 controls were analyzed. Information regarding patient demographics and other potential confounding factors for chronic periodontitis were collected through individual medical records. Results: GERD was revealed to be independently associated with an increased incidence of chronic periodontitis (odds ratio [OR], 2.883; 95% confidence interval [CI], 1.775 to 4.682). The other three variables of dental caries (OR, 1.531; 95% CI, 1.042 to 2.249), tobacco use (OR, 2.335; 95% CI, 1.461 to 3.730), and history of medication (calcium channel blocker, cyclosporine, or phenytoin) (OR, 2.114; 95% CI, 1.160 to 3.854) were also determined to be independent risk factors. Conclusions: The present study supported our hypothesis that GERD can be a risk factor for chronic periodontitis.
Abstract
Background/Aims: The most common cause of chronic periodontitis is poor oral hygiene. Gastroesophageal reflux disease (GERD) enhances the proximal migration of gastric contents and may cause poor oral hygiene. We hypothesized that GERD may increase thse risk of chronic periodontitis and investigated this potential relationship. Methods: A retrospective cross-sectional study was conducted in outpatients between January 1, 2010, and April 30, 2012. GERD was defined as being present based on at least two of the following criteria: etiologic agent(s), identifiable signs and symptoms, and consistent anatomic alterations. A total of 280 patients with chronic periodontitis and 280 controls were analyzed. Information regarding patient demographics and other potential confounding factors for chronic periodontitis were collected through individual medical records. Results: GERD was revealed to be independently associated with an increased incidence of chronic periodontitis (odds ratio [OR], 2.883; 95% confidence interval [CI], 1.775 to 4.682). The other three variables of dental caries (OR, 1.531; 95% CI, 1.042 to 2.249), tobacco use (OR, 2.335; 95% CI, 1.461 to 3.730), and history of medication (calcium channel blocker, cyclosporine, or phenytoin) (OR, 2.114; 95% CI, 1.160 to 3.854) were also determined to be independent risk factors. Conclusions: The present study supported our hypothesis that GERD can be a risk factor for chronic periodontitis.
참고문헌 (42)
- Pihlstrom BL, "Periodontal diseases", Lancet, 366, pp.1809~1820 (2005)
- Eke PI, "Update of the case definitions for population-based surveillance of periodontitis", J Periodontol, 83, pp.1449~1454 (2012)
- Heasman PA, "Cost-effectiveness of adjunctive antimicrobials in the treatment of periodontitis", Periodontol 2000, 55, pp.217~230 (2011)
- Tomar SL, "Public health perspectives on surveillance for periodontal diseases", J Periodontol, 78(7 Suppl), pp.1380~1386 (2007)
- Vakil N, "Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus", Am J Gastroenterol, 101, pp.1900~1920 (2006)
- Richter JE, "The many manifestations of gastroesophageal reflux disease: presentation, evaluation, and treatment", Gastroenterol Clin North Am, 36, pp.577~599 (2007)
- Bartlett D, "Intrinsic causes of erosion", Monogr Oral Sci, 20, pp.119~139 (2006)
- Heidelbaugh JJ, "Atypical presentations of gastroesophageal reflux disease", Am Fam Physician, 78, pp.483~488 (2008)
- Tolia V, "Systematic review: the extra-oesophageal symptoms of gastro-oesophageal reflux disease in children", Aliment Pharmacol Ther, 29, pp.258~272 (2009)
- Crow HC, "Are gingival and periodontal conditions related to salivary gland flow rates in healthy individuals?", J Am Dent Assoc, 126, pp.1514~1520 (1995)
- Farsi N, "Periodontal health and its relationship with salivary factors among different age groups in a Saudi population", Oral Health Prev Dent, 6, pp.147~154 (2008)
- Macfarlane S, "Microbial colonization of the upper gastrointestinal tract in patients with Barrett’s esophagus", Clin Infect Dis, 45, pp.29~38 (2007)
- Pei Z, "Bacterial biota in reflux esophagitis and Barrett’s esophagus", World J Gastroenterol, 11, pp.7277~7283 (2005)
- Dzhamaldinova TD, "Dynamics of inflammatory periodontal diseases under the influence of gastroesophageal reflux disease therapy", Eksp Klin Gastroenterol, pp.46~51 (2010)
- Dzhamaldinova TD, "Manifestations of gastroesophageal reflux disease in the oral cavity", Eksp Klin Gastroenterol, pp.23~27 (2010)
- Karthikeyan BV, "Gingival crevicular fluid and serum leptin: their relationship to periodontal health and disease", J Clin Periodontol, 34, pp.467~472 (2007)
- Loe H, "Periodontal disease in pregnancy. I. Prevalence and severity", Acta Odontol Scand, 21, pp.533~551 (1963)
- Silness J, "Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion", Acta Odontol Scand, 22, pp.121~135 (1964)
- Yamamichi N, "Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores", BMC Med, 10, pp.45~ (2012)
- Vaezi MF, "Use of symptom indices in the management of GERD", Gastroenterol Hepatol (NY), 8, pp.185~187 (2012)
- Heitz-Mayfield LJ, "Disease progression : identification of high-risk groups and individuals for periodontitis", J Clin Periodontol, 32(6), pp.196~209 (2005)
- Kinane DF, "Environmental and other modifying factors of the periodontal diseases", Periodontol 2000, 40, pp.107~119 (2006)
- Takashiba S, "Gene polymorphisms in periodontal health and disease", Periodontol 2000, 40, pp.94~106 (2006)
- Axelsson P, "The long-term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults. Results after 30 years of maintenance", J Clin Periodontol, 31, pp.749~757 (2004)
- Burt BA, "Periodontal disease, tooth loss, and oral hygiene among older Americans", Community Dent Oral Epidemiol, 13, pp.93~96 (1985)
- Hujoel PP, "Personal oral hygiene and chronic periodontitis: a systematic review", Periodontol 2000, 37, pp.29~34 (2005)
- Helm JF, "Effect of esophageal emptying and saliva on clearance of acid from the esophagus", N Engl J Med, 310, pp.284~288 (1984)
- Helm JF, "Salivary response to esophageal acid in normal subjects and patients with reflux esophagitis", Gastroenterology, 93, pp.1393~1397 (1987)
- Kao CH, "Evidence for decreased salivary function in patients with reflux esophagitis", Digestion, 60, pp.191~195 (1999)
- Campisi G, "Saliva variations in gastro-oesophageal reflux disease", J Dent, 36, pp.268~271 (2008)
- Di Fede O, "Oral manifestations in patients with gastro-oesophageal reflux disease: a single-center case-control study", J Oral Pathol Med, 37, pp.336~340 (2008)
- Hirotomi T, "A preliminary study on the relationship between stimulated saliva and periodontal conditions in community-dwelling elderly people", J Dent, 34, pp.692~698 (2006)
- Hirotomi T, "Salivary spinability and periodontal disease progression in an elderly population", Arch Oral Biol, 53, pp.1071~1076 (2008)
- Sarosiek J, "What role do salivary inorganic components play in health and disease of the esophageal mucosa?", Digestion, 56(Suppl 1), pp.24~31 (1995)
- Socransky SS, "Relationship of bacteria to the etiology of periodontal disease", J Dent Res, 49, pp.203~222 (1970)
- Haffajee AD, "Microbial etiological agents of destructive periodontal diseases", Periodontol 2000, 5, pp.78~111 (1994)
- Gorr SU, "Antimicrobial peptides and periodontal disease", J Clin Periodontol, 38(Suppl 11), pp.126~141 (2011)
- Watkins HR, "CCL28 effects on periodontal pathogens", J Periodontol, 78, pp.2356~2363 (2007)
- Bridges RB, "Periodontal status of diabetic and non-diabetic men: effects of smoking, glycemic control, and socioeconomic factors", J Periodontol, 67, pp.1185~1192 (1996)
- Orbak R, "The influence of smoking and non-insulin-dependent diabetes mellitus on periodontal disease", J Int Med Res, 30, pp.116~125 (2002)
- Ryan ME, "The influence of diabetes on the periodontal tissues", J Am Dent Assoc, 134(Spec No), pp.34S~40S (2003)
- Marshall RI, "A clinical review of drug-induced gingival overgrowths", Aust Dent J, 44, pp.219~232 (1999)
