G Protein β3 Subunit Polymorphism and Long-Term Prognosis of Functional Dyspepsia
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Background/Aims: A link between G protein β3 (GNB3)polymorphism and functional dyspepsia (FD) has been suggested. The aim of this study was to determine the role ofGNB3 polymorphism in the long-term prognosis of FD inKoreans. Methods: FD patients and normal healthy controlswere recruited from patients who visited our center betweenDecember 2006 and June 2007. All of the subjects completedRome III questionnaires before undergoing upper gastrointestinalendoscopy and colonoscopy. Genomic DNA was extractedfor GNB3 genotyping. After 5 years, the subjects werereevaluated using the same questionnaires. Results: GNB3825T carrier status was significantly related to FD in Koreans(p=0.04). After 5 years, 61.0% of the initial FD patients and12.2% of the initial normal subjects were diagnosed with FD(odds ratio [OR], 11.7; 95% confidence interval [CI], 4.3 to31.1; p<0.001). Regardless of the GNB3 genotype (p=0.798),female sex was strongly correlated with FD after 5 years (OR,3.3; 95% CI, 1.2 to 9.1; p=0.017). Conclusions: The T alleleof GNB3 is linked to FD in Koreans but does not predict longtermprognosis. Female sex is related to a higher prevalenceof FD after 5 years.
Abstract
Background/Aims: A link between G protein β3 (GNB3)polymorphism and functional dyspepsia (FD) has been suggested. The aim of this study was to determine the role ofGNB3 polymorphism in the long-term prognosis of FD inKoreans. Methods: FD patients and normal healthy controlswere recruited from patients who visited our center betweenDecember 2006 and June 2007. All of the subjects completedRome III questionnaires before undergoing upper gastrointestinalendoscopy and colonoscopy. Genomic DNA was extractedfor GNB3 genotyping. After 5 years, the subjects werereevaluated using the same questionnaires. Results: GNB3825T carrier status was significantly related to FD in Koreans(p=0.04). After 5 years, 61.0% of the initial FD patients and12.2% of the initial normal subjects were diagnosed with FD(odds ratio [OR], 11.7; 95% confidence interval [CI], 4.3 to31.1; p<0.001). Regardless of the GNB3 genotype (p=0.798),female sex was strongly correlated with FD after 5 years (OR,3.3; 95% CI, 1.2 to 9.1; p=0.017). Conclusions: The T alleleof GNB3 is linked to FD in Koreans but does not predict longtermprognosis. Female sex is related to a higher prevalenceof FD after 5 years.
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