The Correlation between NK Cell and Liver Function in Patients with Primary Hepatocellular Carcinoma
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Background/Aims: This study aimed to detect the expressionof natural killer (NK) cell receptor natural killer group2D (NKG2D) in the peripheral blood of patients with primaryhepatocellular carcinoma and to discuss the correlation betweenNK cell cytotoxicity and liver function. Methods: Thenumber of NK cells and the expression of NK cell receptorNKG2D in peripheral blood were determined by flow cytometryin patients with primary hepatocellular carcinoma, hepatitisB cirrhosis, chronic hepatitis B, and healthy controls. Results: When compared with patients in the healthy andthe chronic hepatitis B groups, the primary hepatocellularcarcinoma group showed significant decreases in all parameters,including the cytotoxicity of NK cells on K562 cells,expression rate of NKG2D in NK cells, number of NKG2D+NK cells, expression level of NKG2D, and number of NK cells(p<0.05). The activity of NK cells showed a positive correlation,whereas the Child-Pugh scores in the primary hepatocellularcarcinoma and the hepatitis B cirrhosis groups showeda negative correlation with all parameters detected above. Conclusions: The decrease of NK cell activity in patientswith primary hepatocellular carcinoma is closely related totheir lower expression of NKG2D. Liver function affects theexpression of NKG2D and the activity of NK cells.
Abstract
Background/Aims: This study aimed to detect the expressionof natural killer (NK) cell receptor natural killer group2D (NKG2D) in the peripheral blood of patients with primaryhepatocellular carcinoma and to discuss the correlation betweenNK cell cytotoxicity and liver function. Methods: Thenumber of NK cells and the expression of NK cell receptorNKG2D in peripheral blood were determined by flow cytometryin patients with primary hepatocellular carcinoma, hepatitisB cirrhosis, chronic hepatitis B, and healthy controls. Results: When compared with patients in the healthy andthe chronic hepatitis B groups, the primary hepatocellularcarcinoma group showed significant decreases in all parameters,including the cytotoxicity of NK cells on K562 cells,expression rate of NKG2D in NK cells, number of NKG2D+NK cells, expression level of NKG2D, and number of NK cells(p<0.05). The activity of NK cells showed a positive correlation,whereas the Child-Pugh scores in the primary hepatocellularcarcinoma and the hepatitis B cirrhosis groups showeda negative correlation with all parameters detected above. Conclusions: The decrease of NK cell activity in patientswith primary hepatocellular carcinoma is closely related totheir lower expression of NKG2D. Liver function affects theexpression of NKG2D and the activity of NK cells.
참고문헌 (8)
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