Clinicopathologic Characteristics of Interval Gastric Cancer in Korea
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Background/Aims: Interval gastric cancer (IGC) is defined as cancer that is diagnosed between the time of screening and postscreening esophagogastroduodenoscopy (EGD). Unfortunately, little is known about the characteristics of IGC in Korea, a country with a high incidence of gastric cancer. The aim of this study was to evaluate the clinicopathologic characteristics of IGCs in Korea. Methods: From January 2006 to July 2011, a total of 81,762 subjects underwent screening EGD at Yonsei University Health Promotion Center, Seoul, Korea. We defined missed cancer as cancer diagnosed within 1 year of screening EGD and latent cancer as cancer diagnosed more than 1 year after EGD. Results: A total of 16 IGC patients (17 lesions; three missed cancers and 14 latent cancers) were identified, with a mean age of 60.68 years and a mean interval time of 19.64 months. IGCs tended to be undifferentiated (12/17, 70.6%), located in the lower body of the stomach (12/17, 70.6%) and exhibited flat/depressed endoscopic morphology (11/17, 64.7%). The patients with missed cancer were generally younger than the patients with latent cancer (51.3 years vs 62.8 years, p=0.037), and the patients with undifferentiated cancer were significantly younger than those with differentiated cancer (57.0 years vs 68.8 years, p=0.008). Conclusions: IGCs tended to be undifferentiated, located in the lower body of the stomach, and exhibited flat/depressed endoscopic morphology.
Abstract
Background/Aims: Interval gastric cancer (IGC) is defined as cancer that is diagnosed between the time of screening and postscreening esophagogastroduodenoscopy (EGD). Unfortunately, little is known about the characteristics of IGC in Korea, a country with a high incidence of gastric cancer. The aim of this study was to evaluate the clinicopathologic characteristics of IGCs in Korea. Methods: From January 2006 to July 2011, a total of 81,762 subjects underwent screening EGD at Yonsei University Health Promotion Center, Seoul, Korea. We defined missed cancer as cancer diagnosed within 1 year of screening EGD and latent cancer as cancer diagnosed more than 1 year after EGD. Results: A total of 16 IGC patients (17 lesions; three missed cancers and 14 latent cancers) were identified, with a mean age of 60.68 years and a mean interval time of 19.64 months. IGCs tended to be undifferentiated (12/17, 70.6%), located in the lower body of the stomach (12/17, 70.6%) and exhibited flat/depressed endoscopic morphology (11/17, 64.7%). The patients with missed cancer were generally younger than the patients with latent cancer (51.3 years vs 62.8 years, p=0.037), and the patients with undifferentiated cancer were significantly younger than those with differentiated cancer (57.0 years vs 68.8 years, p=0.008). Conclusions: IGCs tended to be undifferentiated, located in the lower body of the stomach, and exhibited flat/depressed endoscopic morphology.
참고문헌 (27)
- Jemal A, "Global cancer statistics", CA Cancer J Clin, 61, pp.69~90 (2011)
- Siegel R, "Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths", CA Cancer J Clin, 61, pp.212~236 (2011)
- Parkin DM, "Global cancer statistics, 2002", CA Cancer J Clin, 55, pp.74~108 (2005)
- Mizoue T, "Prospective study of screening for stomach cancer in Japan", Int J Cancer, 106, pp.103~107 (2003)
- Carter KJ, "Early gastric cancer", Ann Surg, 199, pp.604~609 (1984)
- Everett SM, "Early gastric cancer in Europe", Gut, 41, pp.142~150 (1997)
- "National cancer control programs in Korea", J Korean Med Sci, 22, pp.S3~S4 (2007)
- Kaminski MF, "Quality indicators for colonoscopy and the risk of interval cancer", N Engl J Med, 362, pp.1795~1803 (2010)
- Pabby A, "Analysis of colorectal cancer occurrence during surveillance colonoscopy in the dietary Polyp Prevention Trial", Gastrointest Endosc, 61, pp.385~391 (2005)
- Raftopoulos SC, "A cohort study of missed and new cancers after esophagogastroduodenoscopy", Am J Gastroenterol, 105, pp.1292~1297 (2010)
- Shiratori Y, "Significance of a gastric mass screening survey", Am J Gastroenterol, 80, pp.831~834 (1985)
- Mori Y, "Effect of periodic endoscopy for gastric cancer on early detection and improvement of survival", Gastric Cancer, 4, pp.132~136 (2001)
- Nam SY, "Effect of repeated endoscopic screening on the incidence and treatment of gastric cancer in health screenees", Eur J Gastroenterol Hepatol, 21, pp.855~860 (2009)
- Lee H, "Survival outcome associated with the screening interval for gastric cancer in Korea", Digestion, 84, pp.142~148 (2011)
- Moriguchi S, "Clinical features of the differentiated and undifferentiated types of advanced gastric carcinoma: univariate and multivariate analyses", J Surg Oncol, 48, pp.202~206 (1991)
- Adachi Y, "Pathology and prognosis of gastric carcinoma: well versus poorly differentiated type", Cancer, 89, pp.1418~1424 (2000)
- Woodman CB, "Is the three year breast screening interval too long? Occurrence of interval cancers in NHS breast screening programme’s north western region", BMJ, 310, pp.224~226 (1995)
- Fujita S, "Biology of early gastric carcinoma", Pathol Res Pract, 163, pp.297~309 (1978)
- Watanabe K, "Accuracy of endoscopic diagnosis of Helicobacter pylori infection according to level of endoscopic experience and the effect of training", BMC Gastroenterol, 13, pp.128~ (2013)
- Anandasabapathy S, "Endoscopic imaging: emerging optical techniques for the detection of colorectal neoplasia", Curr Opin Gastroenterol, 24, pp.64~69 (2008)
- Kadish SL, "Endoscopic diagnosis and management of gastrointestinal malignancy", Oncology, 9, pp.967~983 (1995)
- Choi KS, "Performance of gastric cancer screening by endoscopy testing through the National Cancer Screening Program of Korea", Cancer Sci, 102, pp.1559~1564 (2011)
- Haruma K, "European guideline for the management of precancerous conditions in the stomach and it’s application to Japan", Nihon Rinsho, 71, pp.1479~1484 (2013)
- Kapadia CR, "Gastric atrophy, metaplasia, and dysplasia: a clinical perspective", J Clin Gastroenterol, 36, pp.S29~S36 (2003)
- de Vries AC, "The use of clinical, histologic, and serologic parameters to predict the intragastric extent of intestinal metaplasia: a recommendation for routine practice", Gastrointest Endosc, 70, pp.18~25 (2009)
- Correa P, "Pathology of gastric intestinal metaplasia: clinical implications", Am J Gastroenterol, 105, pp.493~498 (2010)
- Kato I, "Atrophic gastritis and stomach cancer risk: cross-sectional analyses", Jpn J Cancer Res, 83, pp.1041~1046 (1992)