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Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease

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Background/Aims: Deficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD. Methods: Serum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria: patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant. Results: The most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [≥9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis: 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p<0.001). Conclusions: Patients with compensated CLD exhibit a close correlation between vitamin D level and liver stiffness as assessed by TE. Vitamin D deficiency was independently associated with advanced liver fibrosis.

Abstract

Background/Aims: Deficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD. Methods: Serum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria: patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant. Results: The most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [≥9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis: 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p<0.001). Conclusions: Patients with compensated CLD exhibit a close correlation between vitamin D level and liver stiffness as assessed by TE. Vitamin D deficiency was independently associated with advanced liver fibrosis.

참고문헌 (45)

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관련 논문AI추천

The serum vitamin D level is inversely correlated with nonalcoholic fatty liver disease곽민선, 김동희, 양종인, 임선희, 임정윤, 정고은, Mustafa Itani대한간학회 · Clinical and Molecular Hepatology2016 · 제22권 제1호Serum 25(OH)D Levels and Risk of Nonalcoholic Fatty Liver Disease in Nonobese and Lean Individuals강지훈, 김남희연세대학교의과대학 · Yonsei Medical Journal2025 · 제66권 제5호Relationship between Serum 25-hydroxy-vitamin D Concentration and Risk of Metabolic Syndrome in Patients with Fatty Liver김순경, 김태희, 박윤형, 이보라, 이해혁, 임희숙대한골대사학회 · 대한골대사학회지2017 · 제24권 제4호Combination of Transient Elastography and an Enhanced Liver Fibrosis Test to Assess the Degree of Liver Fibrosis in Patients with Chronic Hepatitis B김도영, 김범경, 김승업, 박준용, 안상훈, 한광협, Hyon-Suk Kim, Ja Yoon Heo, Kijun Song, Young Nyun Park거트앤리버 소화기연관학회협의회 · Gut and Liver2018 · 제12권 제2호The factor that improve liver stiffness in patients with chronic hepatitis B권오상, 김윤수, 김주현, 박진웅, 박평화, 여인구, 이정현, 장필규, 최덕주, In Sik Won, Jong Joon Lee, sun young na대한간학회 · Clinical and Molecular Hepatology2015 · 제21권 제1호Effects of vitamin D supplements in patients with chronic hepatitis C: a randomized, multi-center, open label study김형수, 석기태, 심재준, Dae Won Jun, Jae Yoon Jeong, Joo Hyun Sohn, Moon Young Kim, Sang Bong Ahn, Sang Gyune Kim, Se Whan Lee, Sol Ji Park, Soung Won Jeong, Won Kim대한내과학회 · The Korean Journal of Internal Medicine2020 · 제35권 제5호

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