Differences in Prevalence of Lymphovascular Invasion among Early Gastric Cancers between Korea and Japan
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Background/Aims: The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the depth of invasion is the location of cancer cell infiltration in Korea, whereas it is the location of lymphovascular invasion (LVI) or cancer cell infiltration in Japan. We evaluated the characteristics of EGC with LVI to uncover the effects of different diagnostic criteria. Methods: Consecutive T1-stage EGC patients who underwent complete resection were included after endoscopic or surgical resection. The presence of LVI was evaluated. Results: LVI was present in 112 of 1,089 T1-stage EGC patients. LVI was associated with depth of invasion (p<0.001) and age (p=0.017). The prevalence of LVI in mucosal cancer was significantly higher in Korea (p<0.001), whereas that of submucosal cancer was higher in Japan (p=0.024). For mucosal EGC types, LVI was positively correlated with diagnostic criteria applied in Korea (p=0.017). For submucosal EGC types, LVI was positively correlated with Japanese criteria (p=0.001) and old age (p=0.045). Conclusions: The higher prevalence of LVI for mucosal EGC in Korea and for submucosal EGC in Japan indicates that different diagnostic criteria should be considered when reading publications from other countries.
Abstract
Background/Aims: The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the depth of invasion is the location of cancer cell infiltration in Korea, whereas it is the location of lymphovascular invasion (LVI) or cancer cell infiltration in Japan. We evaluated the characteristics of EGC with LVI to uncover the effects of different diagnostic criteria. Methods: Consecutive T1-stage EGC patients who underwent complete resection were included after endoscopic or surgical resection. The presence of LVI was evaluated. Results: LVI was present in 112 of 1,089 T1-stage EGC patients. LVI was associated with depth of invasion (p<0.001) and age (p=0.017). The prevalence of LVI in mucosal cancer was significantly higher in Korea (p<0.001), whereas that of submucosal cancer was higher in Japan (p=0.024). For mucosal EGC types, LVI was positively correlated with diagnostic criteria applied in Korea (p=0.017). For submucosal EGC types, LVI was positively correlated with Japanese criteria (p=0.001) and old age (p=0.045). Conclusions: The higher prevalence of LVI for mucosal EGC in Korea and for submucosal EGC in Japan indicates that different diagnostic criteria should be considered when reading publications from other countries.
참고문헌 (26)
- Schlemper RJ, "Review of histological classifications of gastrointestinal epithelial neoplasia: differences in diagnosis of early carcinomas between Japanese and Western pathologists", J Gastroenterol, 36, pp.445~456 (2001)
- Sakurai U, "Gastric high-grade dysplasia can be associated with submucosal invasion: evaluation of its prevalence in a series of 121 endoscopically resected specimens", Am J Surg Pathol, 38, pp.1545~1550 (2014)
- Vieth M, "The diversity of gastric carcinoma pathogenesis, diagnosis, and therapy", pp.109~116 (2005), Springer-Verlag Tokyo
- Schlemper RJ, "The Vienna classification of gastrointestinal epithelial neoplasia", Gut, 47, pp.251~255 (2000)
- Stolte M, "The new Vienna classification of epithelial neoplasia of the gastrointestinal tract: advantages and disadvantages", Virchows Arch, 442, pp.99~106 (2003)
- Lauwers GY, "Gastric preneoplastic lesions and epithelial dysplasia", Gastroenterol Clin North Am, 36, pp.813~829 (2007)
- Japanese Gastric Cancer Association, "Japanese classification of gastric carcinoma" (2011), Kanehara & Co. Ltd
- Lauwers GY, "WHO classification of tumors of the digestive system", pp.48~58 (2010), International Agency for Research on Cancer
- Isomoto H, "Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study", Gut, 58, pp.331~336 (2009)
- Lee JH, "Prognostic significance of lymphovascular invasion in node-negative gastric cancer", World J Surg, 39, pp.732~739 (2015)
- Kim ER, "Effect of rescue surgery after noncurative endoscopic resection of early gastric cancer", Br J Surg, 102, pp.1394~1401 (2015)
- Yamada T, "Risk factors for submucosal and lymphovascular invasion in gastric cancer looking indicative for endoscopic submucosal dissection", Gastric Cancer, 17, pp.692~696 (2014)
- Zheng Z, "A nomogram for predicting the likelihood of lymph node metastasis in early gastric patients", BMC Cancer, 16, pp.92~ (2016)
- Ahmad R, "Predictors of lymph node metastasis in Western early gastric cancer", J Gastrointest Surg, 20, pp.531~538 (2016)
- Wang Z, "Risk of lymph node metastases from early gastric cancer in relation to depth of invasion: experience in a single institution", Asian Pac J Cancer Prev, 15, pp.5371~3575 (2014)
- Kim H, "Lymphovascular invasion is an important predictor of lymph node metastasis in endoscopically resected early gastric cancers", Oncol Rep, 25, pp.1589~1595 (2011)
- 김세훈, "ERG Immunohistochemistry as an Endothelial Marker for Assessing Lymphovascular Invasion", Journal of Pathology and Translational Medicine, 47(4), pp.355~364 (2013), 대한병리학회[DOI]
- Yonemura Y, "Evaluation of lymphatic invasion in primary gastric cancer by a new monoclonal antibody, D2-40", Hum Pathol, 37, pp.1193~1199 (2006)
- Kim JH, "Additive lymph node dissection may be necessary in minute submucosal cancer of the stomach after endoscopic resection", Ann Surg Oncol, 19, pp.779~785 (2012)
- Lee SH, "Intramucosal gastric cancer: the rate of lymph node metastasis in signet ring cell carcinoma is as low as that in well-differentiated adenocarcinoma", Eur J Gastroenterol Hepatol, 27, pp.170~174 (2015)
- Kim HM, "Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions", Surg Endosc, 25, pp.3087~3093 (2011)
- Park JM, "Is it reasonable to treat early gastric cancer with signet ring cell histology by endoscopic resection? Analysis of factors related to lymph-node metastasis", Eur J Gastroenterol Hepatol, 21, pp.1132~1135 (2009)
- Wang Z, "Clinicopathological features and outcomes in patients undergoing radical resection for early gastric cancer with signet ring cell histology", J Visc Surg, 152, pp.357~361 (2015)
- Kim JW, "Clinical features of second primary cancers arising in early gastric cancer patients after endoscopic resection", World J Gastroenterol, 21, pp.8358~8365 (2015)
- Nozaki I, "Risk factors for metachronous gastric cancer in the remnant stomach after early cancer surgery", World J Surg, 34, pp.1548~1554 (2010)
- Gweon TG, "Increased incidence of secondary gastric neoplasia in patients with early gastric cancer and coexisting gastric neoplasia at the initial endoscopic evaluation", Eur J Gastroenterol Hepatol, 26, pp.1209~1216 (2014)