Prevalence, Awareness, and Treatment of Hepatitis C Virus Infection in South Korea: Evidence from the Korea National Health and Nutrition Examination Survey
1
조회
0
다운로드
9
인용
0
참고문헌
키워드
초록
Background/Aims: This study aimed to investigate the epidemiology of hepatitis C virus (HCV) infection in the Korean general population and the awareness and treatment status of HCV infection among anti-HCV-positive persons. Methods: We used data from the Korea National Health and Nutrition Examination Survey (KNHNES) collected between 2012 and 2016. All the participants aged ≥10 years in the KNHNES were tested for the anti-HCV antibody. Anti-HCV-positive persons were tested for HCV RNA and assessed for their awareness and treatment experience regarding HCV infection. Results: The prevalence of anti-HCV was 0.66% (95% confidence interval, 0.56% to 0.78%) among Koreans aged ≥10 years, representing an estimated 278,819 anti-HCV-positive persons, and 0.71% (95% confidence interval, 0.60% to 0.84%) among Koreans aged ≥20 years. The prevalence of anti-HCV increased with age and had significant geographic variation. The positive rate of HCV RNA in anti-HCV-positive persons was 33.5% and increased with age. The rate of HCV infection awareness was 15.2% (35/250) among anti- HCV-positive persons and 30.5% (18/59) among HCV RNApositive persons. Among the participants, 13.5% of HCV RNA-positive persons had been treated for HCV infection. Conclusions: The prevalence of anti-HCV among Koreans aged ≥20 years was 0.71%; one-third of anti-HCV-positive persons tested HCV RNA-positive. The awareness and treatment rates of HCV infection were low among HCV-infected persons. Therefore, active measures should be taken to diagnose and treat persons unaware of HCV infection.
Abstract
Background/Aims: This study aimed to investigate the epidemiology of hepatitis C virus (HCV) infection in the Korean general population and the awareness and treatment status of HCV infection among anti-HCV-positive persons. Methods: We used data from the Korea National Health and Nutrition Examination Survey (KNHNES) collected between 2012 and 2016. All the participants aged ≥10 years in the KNHNES were tested for the anti-HCV antibody. Anti-HCV-positive persons were tested for HCV RNA and assessed for their awareness and treatment experience regarding HCV infection. Results: The prevalence of anti-HCV was 0.66% (95% confidence interval, 0.56% to 0.78%) among Koreans aged ≥10 years, representing an estimated 278,819 anti-HCV-positive persons, and 0.71% (95% confidence interval, 0.60% to 0.84%) among Koreans aged ≥20 years. The prevalence of anti-HCV increased with age and had significant geographic variation. The positive rate of HCV RNA in anti-HCV-positive persons was 33.5% and increased with age. The rate of HCV infection awareness was 15.2% (35/250) among anti- HCV-positive persons and 30.5% (18/59) among HCV RNApositive persons. Among the participants, 13.5% of HCV RNA-positive persons had been treated for HCV infection. Conclusions: The prevalence of anti-HCV among Koreans aged ≥20 years was 0.71%; one-third of anti-HCV-positive persons tested HCV RNA-positive. The awareness and treatment rates of HCV infection were low among HCV-infected persons. Therefore, active measures should be taken to diagnose and treat persons unaware of HCV infection.
참고문헌 (27)
- "Global hepatitis report, 2017" (2017)[URL]
- Westbrook RH, "Natural history of hepatitis C", J Hepatol, 61(1 Suppl), pp.S58~S68 (2014)
- European Association for the Study of the Liver, "EASL recommendations on treatment of hepatitis C 2016", J Hepatol, 66, pp.153~194 (2017)
- AASLD-IDSA HCV Guidance Panel, "Hepatitis C Guidance 2018Update : AASLD-IDSA recommendations for testing, managing, and treating hepatitis C virus infection", Clin Infect Dis, 67, pp.1477~1492 (2018)
- "Combating hepatitis B and C to reach elimination by 2030" (2016)[URL]
- Shin HR, "Epidemiology of hepatitis C virus in Korea", Intervirology, 49, pp.18~22 (2006)
- Kim DY, "A nationwide seroepidemiology of hepatitis C virus infection in South Korea", Liver Int, 33, pp.586~594 (2013)
- Kweon S, "Data resource profile : the Korea National Health and Nutrition Examination Survey(KNHANES)", Int J Epidemiol, 43, pp.69~77 (2014)
- 김경아, "Geographic difference of epidemiological features of HCV infection in Korea", Clinical and Molecular Hepatology, 20(4), pp.361~367 (2014), 대한간학회
- Marcellin P, "Therapy of hepatitis C : patients with normal aminotransferase levels", Hepatology, 26(3 Suppl 1), pp.133S~136S (1997)
- Puoti C, "Histological and virological features and follow-up of hepatitis C virus carriers with normal aminotransferase levels : the Italian prospective study of the asymptomatic C carriers(ISACC)", J Hepatol, 37, pp.117~123 (2002)
- 오덕자, "Prevalence of Hepatitis C Virus Infections and Distribution of Hepatitis C Virus Genotypes amongKorean Blood Donors", Annals of Laboratory Medicine, 32(3), pp.210~215 (2012), 대한진단검사의학회[DOI]
- Hofmeister MG, "Estimating Prevalence of Hepatitis C Virus Infection in the United States, 2013-2016", Hepatology, 69, pp.1020~1031 (2019)
- Petruzziello A, "Global epidemiology of hepatitis C virus infection : an up-date of the distribution and circulation of hepatitis C virus genotypes", World J Gastroenterol, 22, pp.7824~7840 (2016)
- Pawlotsky JM, "Use and interpretation of virological tests for hepatitis C", Hepatology, 36(5 Suppl 1), pp.S65~S73 (2002)
- Moorman AC, "Prevalence of false-positive hepatitis C antibody results, National Health and Nutrition Examination Study(NHANES)2007-2012", J Clin Virol, 89, pp.1~4 (2017)
- Aisyah DN, "Assessing hepatitis C spontaneous clearance and understanding associated factors : a systematic review and meta-analysis", J Viral Hepat, 25, pp.680~698 (2018)
- Thomas DL, "Genetic variation in IL28B and spontaneous clearance of hepatitis C virus", Nature, 461, pp.798~801 (2009)
- Cho EJ, "Current status and strategies for hepatitis B control in Korea", Clin Mol Hepatol, 23, pp.205~211 (2017)
- Lyoo K, "Polymorphism near the IL28B gene in Korean hepatitis C virus-infected patients treated with peginterferon plus ribavirin", J Clin Virol, 52, pp.363~366 (2011)
- Kim JY, "Acute hepatitis C in Korea : different modes of infection, high rate of spontaneous recovery, and low rate of seroconversion", J Med Virol, 83, pp.1195~1202 (2011)
- Papatheodoridis GV, "Hepatitis C : the beginning of the end-key elements for successful European and national strategies to eliminate HCV in Europe", J Viral Hepat, 25(Suppl 1), pp.6~17 (2018)
- Shin A, "Factors associated with awareness of infection status among chronic hepatitis B and C carriers in Korea", Cancer Epidemiol Biomarkers Prev, 18, pp.1894~1898 (2009)
- Ahn HR, "Socioeconomic differences in self-and family awareness of viral hepatitis status among carriers of hepatitis B or C in rural Korea", Am J Infect Control, 46, pp.328~332 (2018)
- Denniston MM, "Awareness of infection, knowledge of hepatitis C, and medical followup among individuals testing positive for hepatitis C : National Health and Nutrition Examination Survey 2001-2008", Hepatology, 55, pp.1652~1661 (2012)
- Kim HS, "Awareness of chronic viral hepatitis in the United States : an update from the National Health and Nutrition Examination Survey", J Viral Hepat, 26, pp.596~602 (2019)
- 기모란, "Healthcare Costs for Chronic Hepatitis C in South Korea from 2009 to 2013: An Analysis of the National Health Insurance Claims’ Data", Gut and Liver, 11(6), pp.835~842 (2017), 거트앤리버 소화기연관학회협의회