Venous Thromboembolism Risk in Asian Patients with Inflammatory Bowel Disease: A Population-Based Nationwide Inception Cohort Study
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background/Aims: Inflammatory bowel disease (IBD) is associated with the occurrence of venous thromboembolism (VTE). However, to date, there have been few studies on the risk of VTE in Asian IBD patients. We aimed to estimate the incidence of VTE in Asian IBD patients and to determine if IBD is related to increased VTE risk. Methods: We performed a population-based cohort study between 2004 and 2015 using Korean National Health Insurance data. IBD and VTE were defined by ICD-10 codes. Incidence rates of VTE were calculated among patients with IBD and among age- and sex-matched controls. Hazard ratios were estimated using Cox regression with adjustment for multiple variables. We performed additional analyses stratifying by age, sex, Charlson comorbidity index (CCI) score, and disease type. Results: Among the 45,037 patients with IBD (IBD cohort) and 133,019 matched controls (non- IBD cohort) included in our analysis, 411 IBD patients and 641 controls developed VTE. The IBD cohort had a higher incidence rate ratio and risk of VTE than the non-IBD cohort (incidence rate ratio: 1.92 and hazard ratio: 1.93). Older age, female sex, higher CCI scores, cardiovascular disease, chronic kidney disease, use of steroids, and hospitalization were significant risk factors for VTE in patients with IBD. Conclusions: The IBD patients in this study were approximately two times more likely to develop VTE than the non-IBD individuals. Our findings support the need for thromboprophylaxis in Asian IBD patients with various factors that further increase the risk of VTE.
Abstract
Background/Aims: Inflammatory bowel disease (IBD) is associated with the occurrence of venous thromboembolism (VTE). However, to date, there have been few studies on the risk of VTE in Asian IBD patients. We aimed to estimate the incidence of VTE in Asian IBD patients and to determine if IBD is related to increased VTE risk. Methods: We performed a population-based cohort study between 2004 and 2015 using Korean National Health Insurance data. IBD and VTE were defined by ICD-10 codes. Incidence rates of VTE were calculated among patients with IBD and among age- and sex-matched controls. Hazard ratios were estimated using Cox regression with adjustment for multiple variables. We performed additional analyses stratifying by age, sex, Charlson comorbidity index (CCI) score, and disease type. Results: Among the 45,037 patients with IBD (IBD cohort) and 133,019 matched controls (non- IBD cohort) included in our analysis, 411 IBD patients and 641 controls developed VTE. The IBD cohort had a higher incidence rate ratio and risk of VTE than the non-IBD cohort (incidence rate ratio: 1.92 and hazard ratio: 1.93). Older age, female sex, higher CCI scores, cardiovascular disease, chronic kidney disease, use of steroids, and hospitalization were significant risk factors for VTE in patients with IBD. Conclusions: The IBD patients in this study were approximately two times more likely to develop VTE than the non-IBD individuals. Our findings support the need for thromboprophylaxis in Asian IBD patients with various factors that further increase the risk of VTE.
참고문헌 (51)
- Emiko Mizoguchi, "Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models", Intestinal research, 18(2), pp.151~167 (2020), 대한장연구학회[DOI]
- 김정민, "Pathogenesis and clinical perspectives of extraintestinal manifestations in inflammatory bowel diseases", Intestinal research, 18(3), pp.249~264 (2020), 대한장연구학회[DOI]
- Grainge MJ, "Venous thromboembolism during active disease and remission in inflammatory bowel disease : a cohort study", Lancet, 375, pp.657~663 (2010)
- Kappelman MD, "Thromboembolic risk among Danish children and adults with inflammatory bowel diseases : a population-based nationwide study", Gut, 60, pp.937~943 (2011)
- Murthy SK, "Venous thromboembolism in inflammatory bowel disease : an epidemiological review", Am J Gastroenterol, 106, pp.713~718 (2011)
- Ng SC, "Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century : a systematic review of population-based studies", Lancet, 390, pp.2769~2778 (2017)
- Coward S, "Past and future burden of inflammatory bowel diseases based on modeling of population-based data", Gastroenterology, 156, pp.1345~1353 (2019)
- Yuhara H, "Meta-analysis : the risk of venous thromboembolism in patients with inflammatory bowel disease", Aliment Pharmacol Ther, 37, pp.953~962 (2013)
- Chu TP, "The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity", Aliment Pharmacol Ther, 48, pp.1099~1108 (2018)
- Miehsler W, "Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism?", Gut, 53, pp.542~548 (2004)
- Cheng K, "Venous thromboembolism in inflammatory bowel disease", World J Gastroenterol, 26, pp.1231~1241 (2020)
- Nguyen GC, "Consensus statements on the risk, prevention, and treatment of venous thromboembolism in inflammatory bowel disease : Canadian Association of Gastroenterology", Gastroenterology, 146, pp.835~848 (2014)
- Gionchetti P, "3rd European evidence-based consensus on the diagnosis and management of Crohn’s disease 2016 : part 2 : surgical management and special situations", J Crohns Colitis, 11, pp.135~149 (2017)
- Bitton A, "Treatment of hospitalized adult patients with severe ulcerative colitis : Toronto consensus statements", Am J Gastroenterol, 107, pp.179~194 (2012)
- Faye AS, "Acute venous thromboembolism risk highest within 60 days after discharge from the hospital in patients with inflammatory bowel diseases", Clin Gastroenterol Hepatol, 18, pp.1133~1141 (2020)
- Higgins PD, "Increased risk of venous thromboembolic events with corticosteroid vs biologic therapy for inflammatory bowel disease", Clin Gastroenterol Hepatol, 13, pp.316~321 (2015)
- Chung WS, "Inflammatory bowel disease increases the risks of deep vein thrombosis and pulmonary embolism in the hospitalized patients : a nationwide cohort study", Thromb Res, 135, pp.492~496 (2015)
- McCurdy JD, "Risk of venous thromboembolism after hospital discharge in patients with inflammatory bowel disease : a population-based study", Inflamm Bowel Dis, 26, pp.1761~1768 (2020)
- McKie K, "Risk factors for venous thromboembolism in children and young adults with inflammatory bowel disease", J Surg Res, 243, pp.173~179 (2019)
- Park SH, "A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong district of Seoul, Korea in 1986-2015", J Crohns Colitis, 13, pp.1410~1417 (2019)
- Cha JM, "Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea", Gut, 69, pp.1432~1440 (2020)
- Chuang CH, "Increasing incidence and lifetime risk of inflammatory bowel disease in Taiwan : a nationwide study in a low-endemic area 1998-2010", Inflamm Bowel Dis, 19, pp.2815~2819 (2013)
- Ng SC, "Incidence and phenotype of inflammatory bowel disease based on results from the Asiapacific Crohn’s and colitis epidemiology study", Gastroenterology, 145, pp.158~165 (2013)
- 송혜경, "Quality of care in inflammatory bowel disease in Asia: the results of a multinational web-based survey in the 2nd Asian Organization of Crohn’s and Colitis (AOCC) meeting in Seoul", Intestinal research, 14(3), pp.240~247 (2016), 대한장연구학회
- Cheuk BL, "Epidemiology of venous thromboembolism in a Chinese population", Br J Surg, 91, pp.424~428 (2004)
- Oger E, "Incidence of venous thromboembolism : a community-based study in Western France. EPI-GETBP Study Group. Groupe d’Etude de la Thrombose de Bretagne Occidentale", Thromb Haemost, 83, pp.657~660 (2000)
- 송선옥, "Background and Data Configuration Process of a Nationwide Population-Based Study Using the Korean National Health Insurance System", Diabetes and Metabolism Journal, 38(5), pp.395~403 (2014), 대한당뇨병학회[DOI]
- Jung YS, "Cancer risk in the early stages of inflammatory bowel disease in Korean patients : a nationwide population-based study", J Crohns Colitis, 11, pp.954~962 (2017)
- Jung YS, "Incidence and clinical outcomes of inflammatory bowel disease in South Korea, 2011-2014 : a nationwide population-based study", Dig Dis Sci, 62, pp.2102~2112 (2017)
- Lee CK, "Nationwide validation study of diagnostic algorithms for inflammatory bowel disease in Korean National Health Insurance Service database", J Gastroenterol Hepatol, 35, pp.760~768 (2020)
- Seong SC, "Data resource profile : the National Health Information Database of the National Health Insurance Service in South Korea", Int J Epidemiol, 46, pp.799~800 (2017)
- Lee J, "Cohort profile : the National Health Insurance Service-National Sample Cohort(NHIS-NSC), South Korea", Int J Epidemiol, 46, pp.e15~ (2017)
- Bernard TJ, "The institution-based prospective inception cohort study : design, implementation, and quality assurance in pediatric thrombosis and stroke research", Semin Thromb Hemost, 39, pp.10~14 (2013)
- Bernstein CN, "The incidence of deep venous thrombosis and pulmonary embolism among patients with inflammatory bowel disease : a population-based cohort study", Thromb Haemost, 85, pp.430~434 (2001)
- Stein PD, "Pulmonary thromboembolism in Asians", Pacific Islanders in the United States : analysis of data from the National Hospital Discharge Survey and the United States Bureau of the Census, 2004, pp.116, 435~442
- Steffen LM, "Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism : the Longitudinal Investigation of Thromboembolism Etiology", Circulation, 115, pp.188~195 (2007)
- Sam JJ, "Physicians’ perceptions of risks and practices in venous thromboembolism prophylaxis in inflammatory bowel disease", Dig Dis Sci, 58, pp.46~52 (2013)
- Ra G, "Predictors and safety of venous thromboembolism prophylaxis among hospitalized inflammatory bowel disease patients", J Crohns Colitis, 7, pp.e479~e485 (2013)
- Tinsley A, "A survey of current practice of venous thromboembolism prophylaxis in hospitalized inflammatory bowel disease patients in the United States", J Clin Gastroenterol, 47, pp.e1~e6 (2013)
- Papa A, "Prevention and treatment of venous thromboembolism in patients with IBD : a trail still climbing", Inflamm Bowel Dis, 21, pp.1204~1213 (2015)
- Nylund CM, "Venous thrombotic events in hospitalized children and adolescents with inflammatory bowel disease", J Pediatr Gastroenterol Nutr, 56, pp.485~491 (2013)
- Papa A, "Venous thromboembolism in patients with inflammatory bowel disease : focus on prevention and treatment", World J Gastroenterol, 20, pp.3173~3179 (2014)
- Steven Nicolaides, "Inflammatory bowel disease and superior mesenteric artery thromboembolism", Intestinal research, 18(1), pp.130~133 (2020), 대한장연구학회
- Marcello Rabello Imbrizi, "Hypoalbuminemia as a risk factor for thromboembolic events in inflammatory bowel disease inpatients", Intestinal research, 17(1), pp.63~69 (2019), 대한장연구학회[DOI]
- Jing Liu, "Incidence and risk factors for venous thrombosis among patients with inflammatory bowel disease in China: a multicenter retrospective study", Intestinal research, 19(3), pp.313~322 (2021), 대한장연구학회[DOI]
- Kaddourah O, "Venous thromboembolism prophylaxis in inflammatory bowel disease flare-ups", Ann Gastroenterol, 32, pp.578~583 (2019)
- Goto S, "Assessment of outcomes among patients with venous thromboembolism with and without chronic kidney disease", JAMA Netw Open, 3, pp.e2022886~ (2020)
- Sarlos P, "Steroid but not biological therapy elevates the risk of venous thromboembolic events in inflammatory bowel disease : a meta-analysis", J Crohns Colitis, 12, pp.489~498 (2018)
- Johannesdottir SA, "Use of glucocorticoids and risk of venous thromboembolism : a nationwide population-based case-control study", JAMA Intern Med, 173, pp.743~752 (2013)
- van der Pas R, "Hypercoagulability in Cushing’s syndrome:prevalence, pathogenesis and treatment", Clin Endocrinol(Oxf), 78, pp.481~488 (2013)
- Ananthakrishnan AN, "Management of inflammatory bowel disease in the elderly patient : challenges and opportunities", Inflamm Bowel Dis, 23, pp.882~893 (2017)