노인성 난청의 한약 치료에 대한 체계적 문헌고찰: 腎虛을 중점으로
Systematic Review on Presbycusis Treated by Herbal Medicine Focusing on Kidney Deficiency
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Objectives : This study was conducted to approve the effectiveness and safety of herbal medicine on presbycusis with kidney deficiency. Methods : We searched randomized controlled trials(RCTs) on presbycusis patients diagnosed with kidney deficiency through 10 electronic databases from the start to Sep 7, 2021. Study collection and data extraction, and evaluation of risk of bias were conducted by two independent collaborator. The evaluation of the risk of bias in included RCTs was carried out by using Cochrane risk-of-bias tool. And the data synthesis was conducted by using Review Manager(RevMan, ver.5.4). Results : 1. The treatment group which used herbal medicine(HM) alone was more effective than the control group which used only western medicine(WM) on effective rate of hearing loss. 2. In 3 studies comparing the HM-WM combination treatment group with the control groups using the same WM treatment, the effective rate was statistically significantly higher in the HM-WM combination treatment group. 3. Of the 5 studies that reported adverse reactions, one study reported mild nausea and dizziness, but the difference between the HM treatment group and the WM control group was not statistically significant, and no side effects occurred in other 3 studies. 4. In studies comparing HM and WM, the HM treatment group improved hearing loss, whole blood viscosity, serum TNF-α, IL-1β, IL-6, and oxidative stress indicators better than the WM control group, and there was no significant difference. 5. In studies comparing the HM-WM treatment group with the WM control group, the severity of tinnitus, quality of life, and feelings of anxiety and depression were better in the treatment group than the control group. Conclusions : This study shows that the herbal medicine can improve symptoms of presbycusis with kidney deficiency.
Abstract
Objectives : This study was conducted to approve the effectiveness and safety of herbal medicine on presbycusis with kidney deficiency. Methods : We searched randomized controlled trials(RCTs) on presbycusis patients diagnosed with kidney deficiency through 10 electronic databases from the start to Sep 7, 2021. Study collection and data extraction, and evaluation of risk of bias were conducted by two independent collaborator. The evaluation of the risk of bias in included RCTs was carried out by using Cochrane risk-of-bias tool. And the data synthesis was conducted by using Review Manager(RevMan, ver.5.4). Results : 1. The treatment group which used herbal medicine(HM) alone was more effective than the control group which used only western medicine(WM) on effective rate of hearing loss. 2. In 3 studies comparing the HM-WM combination treatment group with the control groups using the same WM treatment, the effective rate was statistically significantly higher in the HM-WM combination treatment group. 3. Of the 5 studies that reported adverse reactions, one study reported mild nausea and dizziness, but the difference between the HM treatment group and the WM control group was not statistically significant, and no side effects occurred in other 3 studies. 4. In studies comparing HM and WM, the HM treatment group improved hearing loss, whole blood viscosity, serum TNF-α, IL-1β, IL-6, and oxidative stress indicators better than the WM control group, and there was no significant difference. 5. In studies comparing the HM-WM treatment group with the WM control group, the severity of tinnitus, quality of life, and feelings of anxiety and depression were better in the treatment group than the control group. Conclusions : This study shows that the herbal medicine can improve symptoms of presbycusis with kidney deficiency.
참고문헌 (31)
- Gates GA, "Presbycusis", Lancet, 366, pp.1111~1120 (2005)
- Lemke U, "Oral communication in individuals with hearing impairmentconsiderations regarding attentional, cognitive and social resources", Frontiers in Psychology, 6, pp.998~ (2013)
- Saito H, "Hearing handicap predicts the development of depressive symptoms after 3 years in older community-dwelling Japanese", Journal of the American Geriatrics Society, 58(1), pp.93~97 (2010)
- Lin FR, "Hearing loss and cognitive decline in older adults", JAMA Internal Medicine, 173(4), pp.293~299 (2013)
- "Statistics Korea" (2021)[URL]
- "Korean statistical information service" (2019)[URL]
- Wang J, "Presbycusis : An Update on Cochlear Mechanisms and Therapies", J Clin Med, 9(1), pp.218~ (2020)
- 제하경, "한방 복합 치료 및 소리 재활 치료로 호전된 노인성 난청 치험 1례", 한방안이비인후피부과학회지, 34(3), pp.102~111 (2021), 대한한방안이비인후피부과학회
- Zhang YP, "Curative Observation on Modified Bushen Tongqiao Decoction in the Treatment for Presbycusis", Western Journal of Traditional Chinese Medicine, 9, pp.66~68 (2019)
- Zhang N, "Clinical research on presbycusis by Tonifying the Kidney, Promoting Blood Circulation and Clearing Orifice", pp.2018
- Shi WH, "Observation on Curative Effect of Combination of Traditional Chinese and Western Medicine in Treating Senile Deafness", Guangming Journal of Chinese Medicine, 6, pp.1286~ (2015)
- Luo Y, "Effect of Erlongzuoci Pill on Serum TNF-α, IL-1β and IL-6 in Aged Patients with Kidney Deafness", Progress in Modern Biomedicine, 25, pp.4930~4933 (2015)
- Huang ST, "Clinical Study on Bushen Tianjing Fang in Senile Deafness and Tinnitus of Kidney Essence Deficiency Syndrome", Guiding Journal of Traditional Chinese Medicine and Pharmacy, 5, pp.82~85 (2021)
- Yang X, "Observation of Yishen Zhihong Granules on Improving Clinical Curative Effect of Senile Deafness", pp.2013
- Li L, "Clinical Observation on the Therapeutic Effect of Gushen Peiyuan Fang in Treating 35 Patients of Presbycusis", Journal of Liaoning University of Traditional Chinese Medicine, 7, pp.111~ (2012)
- Chai F, "Study on Cong'er Pills in Improving High-frequency Hearing Threshold of Senile Deafness with Kidney Deficiency", Chinese Journal of Information on TCM, 1, pp.47~ (2000)
- Zhong P, "Reinforce the Kidney and Activate Blood Circulation Treatment of Presbycusis and Effect on the Quality of Life", pp.2011
- Whang WY, "The Clinical Research of Huoxuefancongtang for The Treatment of Presbycusis", pp.2016
- Dong HL, "Toniyfing the Kidney and Promoting Blood Circulation in Treating Senile Deafness: Clinical Study", pp.2012
- Wu YC, "Influence of Ginkgo Biloba Extract combined with Erlong Zuoci Pills treatment on hemorheology of patients with kidney deficiency type presbycusis", China Modern Medicine, 11, pp.104~106 (2017)
- Wang TJ, "Investigation on the degree of hearing loss in senile deafness and TCM syndrome differentiation and treatment", Chinese Journal of Gerontology, 15, pp.2840~2842 (2011)
- Heo J, "Donguibogam", pp.3290~3762 (2013), Ministry of Health &Welfare
- Song BB, "Protection from gentamicin ototoxicity by iron chelators in guinea pig in vivo", J Pharmacol Exp Ther, 282, pp.369~377 (1997)
- 김상훈, "노인성난청", Hanyang Medical Reviews, 35(2), pp.78~83 (2015), 한양대학교 의과대학[DOI]
- "The Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2)" (2015)[URL]
- 신상우, "대표적 보기약인 인삼, 당삼, 황기, 백출, 산약 물추출액의 면역조절효과 비교", 동의생리병리학회지, 18(4), pp.1140~1146 (2004), 한의병리학회
- 박영철, "숙지황(Rehmannia glutinosa)의 약리작용과 독성", 대한한의학 방제학회지, 19(1), pp.145~160 (2011), 대한한의학방제학회
- 신동철, "황칠나무, 산수유, 구기자 복합 초임계유체추출물의 항산화 및 항노화 효과", 대한본초학회지, 28(6), pp.95~100 (2013), 대한본초학회
- Park YC, "Effects of Ligusticum Chuanxiang on blood circulation and oxidative stress", Kor J Oriental Preventive Medical Society, 6(2), pp.86~94 (2002)
- 양영이, "택사 열수 및 에탄올 추출물의 항산화활성과 human LDL 산화억제 및 ACE 저해효과에 미치는 영향", 대한한방내과학회지, 29(4), pp.988~999 (2008), 대한한방내과학회
- Jo HJ, "Studies on the NO Production and Expression Induction Effect of NOS Gene by Salviae Radix", J Korean Oriental Med, 21(3), pp.20~30 (2000)