玉屛風散合小靑龍湯이 알레르기 비염 모델 흰 쥐에 미치는 영향

Abstract

Backgroud : Allergic rhinitis is an inflammation of the nasal mucosa which is characterized by sneezing, coughing, itchy nose, mouth and throat, congestion and/or nasal discharge. Object : We have studied effects of the Okbyeongpung-san plus Socheongryong-tang on the change of the amounts of IL-4, Il-5, IFN-γ and total IgE in rats with OVA-induced allergic rhinitis. Method : The 15 rats were divided into three groups ; normal group, control group, and sample group. To induce allergic rhinitis in control group and sample group , rats were sensitized intraperitoneally with 0.1% ovalbumin(OVA) solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin(OVA) solution 3 times at intervals of 2 days. After that time, rats in the sample group were oral administration treated by Okbyeongpung-san plus Socheongryong-tang 28 days. We observed the change of the amounts of IL-4, Il-5, IFN-γ and total IgE in rats in each group. Result : 1. In Total IgE study, the treated group was proved significant inhibitory effect(p<0.05> 2. In Interleukin-4(IL-4) study, the treated group was proved significant inhibitory effect(p<0.001> 3. In IL-5 study, the treated group was proved significant inhibitory effect(p<0.001> 4. In Interferone-γ(IFN-γ) study, the treated group was proved significant inhibitory effect(p<0.005> Conclusion : According to the above results, it is considered that the Okbyeongpung-san plus Socheongryong-tang has inhibitory effects on the allergic rhinitis of rats.