補骨脂의 高梁酒, 燒酒 추출물이 B16 melanoma세포주의 멜라닌 합성에 미치는 영향
The effcect of Gorynju and a Soju extract Psoraleae fructus onMelanin synthesis of B16 melanoma cells
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Objective : This research was carried out to compare the effect of Gorynju and a Soju extract Psoraleae fructus on melanin synthesis of B16 melanoma cells. Methods : To investigate melanin synthesis of B16 melanoma cells, this research was measured cell survival, tyrosinase activity, melanin synthesis, western blot. Results : Both Gorynju and Soju extract Psoraleae fructus, cell toxicity depended on the density. Tyrosinase activity depended on the density of Gorynju extract Psoraleae fructus and statistic was showed significant(0.5, 1, 2, 3 ㎍/㎖), in a Soju extract Psoraleae fructus, 1 ㎍/㎖ were showed significant. Melanin synthesis was showed significant in a Soju extract Psoraleae fructus(3, 4 ㎍/㎖). Western blot was showed to depend on the density of Gorynju and a Soju extract Psoraleae fructus. Conclusions : In a tyrosinase activity and a melanin synthesis, the intermediate alcohol of Gorynju and a Soju may be suitable to use.
Abstract
Objective : This research was carried out to compare the effect of Gorynju and a Soju extract Psoraleae fructus on melanin synthesis of B16 melanoma cells. Methods : To investigate melanin synthesis of B16 melanoma cells, this research was measured cell survival, tyrosinase activity, melanin synthesis, western blot. Results : Both Gorynju and Soju extract Psoraleae fructus, cell toxicity depended on the density. Tyrosinase activity depended on the density of Gorynju extract Psoraleae fructus and statistic was showed significant(0.5, 1, 2, 3 ㎍/㎖), in a Soju extract Psoraleae fructus, 1 ㎍/㎖ were showed significant. Melanin synthesis was showed significant in a Soju extract Psoraleae fructus(3, 4 ㎍/㎖). Western blot was showed to depend on the density of Gorynju and a Soju extract Psoraleae fructus. Conclusions : In a tyrosinase activity and a melanin synthesis, the intermediate alcohol of Gorynju and a Soju may be suitable to use.
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