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여드름 한약 치료의 무작위 대조군 임상연구에 관한 분석

Analysis of Randomized Controlled Trial Study of Korean Herbal Medicine Treatment for Acne

지선영|서형식|황보민|권강|이마음|김철윤
대한한방안이비인후피부과학회 (The Korean Medicine Opthalmology&Otolaryngology&Dermatology Society)|2022.11|한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology&Otorhinolaryngology&Dermatology)|제35권 제4호|pp. 139-162

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Systematic reviewMeta-analysisHerbal medicineAcneRandomized controlled trial
주제분류한의학

초록

Objectives : The review was conducted to validate the effectiveness of herbal medicines on acne. Methods : Randomized controlled trials(RCTs) reporting the effects of herbal medicine treatment on acne were searched through seven electronic databases from the time of application of the material to October 2021. Cochrane Collaboration's Risk of Bias was used to assess the risk of bias. Analysis was performed using Review Manager 5.4 and R 4.1.0 Meta, Metafor program. Results : 34 RCTs was selected and meta-analysis was performed with 30 studies. The inflammatory lesion count of the herbal medicine(MD=0.29, 95% CI:-0.59-0.01, p<0.01, I 2 =80%) and the non inflammatory lesion count of herbal medicine(MD=-0.30, 95% CI:-0.70-0.10, p<0.01, I 2 =78%) were seen. The score of IGA(RR=1.43, 95% CI:0.90-2.27, p<0.91, I 2 =0%), VISIA(MD=0.36, 95% CI:0.21-0.51, p=0.07, I 2 =40%), effective rate(RR=1.23, 95% CI:1.05-1.44, p<0.01, I 2 =98%), DLQI(MD : 0.59, 95% CI:0.14-1.04, p=0.07, I 2 =63%) and recurrence rate(RR=0.36, 95% CI:0.23-0.58, p=0.73, I 2 =0%) were seen. The effective rate of herbal medicine were statistically higher that of the control group(WM)(RR=1.19, 95% CI:1.04-1.37, p<0.01, I 2 =97%). As a result of dividing the treatment groups into OHM, EHM, and OEHM, the EHM group(RR=1.17, 95% CI:0.79-1.72, p<0.01, I 2 =99%) showed the most statistically significant effect. The overall risk of bias of the included studies was some concerns. No serious adverse effects were observed. Conclusions : This review found the effectiveness of herbal medicine for acne.

Abstract

Objectives : The review was conducted to validate the effectiveness of herbal medicines on acne. Methods : Randomized controlled trials(RCTs) reporting the effects of herbal medicine treatment on acne were searched through seven electronic databases from the time of application of the material to October 2021. Cochrane Collaboration's Risk of Bias was used to assess the risk of bias. Analysis was performed using Review Manager 5.4 and R 4.1.0 Meta, Metafor program. Results : 34 RCTs was selected and meta-analysis was performed with 30 studies. The inflammatory lesion count of the herbal medicine(MD=0.29, 95% CI:-0.59-0.01, p<0.01, I 2 =80%) and the non inflammatory lesion count of herbal medicine(MD=-0.30, 95% CI:-0.70-0.10, p<0.01, I 2 =78%) were seen. The score of IGA(RR=1.43, 95% CI:0.90-2.27, p<0.91, I 2 =0%), VISIA(MD=0.36, 95% CI:0.21-0.51, p=0.07, I 2 =40%), effective rate(RR=1.23, 95% CI:1.05-1.44, p<0.01, I 2 =98%), DLQI(MD : 0.59, 95% CI:0.14-1.04, p=0.07, I 2 =63%) and recurrence rate(RR=0.36, 95% CI:0.23-0.58, p=0.73, I 2 =0%) were seen. The effective rate of herbal medicine were statistically higher that of the control group(WM)(RR=1.19, 95% CI:1.04-1.37, p<0.01, I 2 =97%). As a result of dividing the treatment groups into OHM, EHM, and OEHM, the EHM group(RR=1.17, 95% CI:0.79-1.72, p<0.01, I 2 =99%) showed the most statistically significant effect. The overall risk of bias of the included studies was some concerns. No serious adverse effects were observed. Conclusions : This review found the effectiveness of herbal medicine for acne.

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