본문 바로가기
KERD
논문KCI 등재

건선 환자에서 아시트레틴 치료에 추가한 한방 약욕 효과 : 체계적 문헌 고찰과 메타 분석

Add-on Effect of Herbal Bath Combined with Acitretin Treatment in Patients with Psoriasis : Systemic Review and Meta-analysis

이지은|박수진|김규석|전서연
대한한방안이비인후피부과학회 (The Korean Medicine Opthalmology&Otolaryngology&Dermatology Society)|2023.08|한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology&Otorhinolaryngology&Dermatology)|제36권 제3호|pp. 74-98

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

Systematic reviewMeta-analysisPsoriasisHerbal bathAcitretin
주제분류한의학

초록

Objectives : This study aims to evaluate the add-on effect of herbal bath combined with acitretin in patients with psoriasis. Methods : We searched randomized controlled trials(RCTs) reporting the effect of herbal bath and acitretin combined treatment for psoriasis in 10 electronic databases from their inception to January 2023. Study collection, data extraction, and risk of bias assessment were performed by two independent researchers. Data synthesis and risk of bias evaluation was conducted using Revman 5.4. Results : Ten RCTs with 1,008 subjects were included. Herbal bath and acitretin combined treatment group showed higher average total effective rate than acitretin alone group(RR 1.39; 95% CI: 1.15-1.68, P=0.0006, I 2=0%). Herbal bath and additional treatments such as phototherapy(NB-UVB) and oral herbal medicine, combined with acitretin group also showed higher average total effective rate than acitretin alone group(RR 1.81; 95% CI: 1.47-2.22, P<0.00001, I2=43%). Herbal bath and phototherapy(NB-UVB) combined with acitretin group also showed higher average total effective rate than acitretin alone group(RR 1.51; 95% CI: 1.18-1.93, P=0.0009, I2=0%). The overall risk of bias of the included studies was unclear or of high risks. Conclusions : This review showed that the add-on of herbal bath combined with acitretin treatment could be more effective than acitretin alone treatment in patients with psoriasis. However, because of few included studies, heterogeneity between studies, and insufficient quality of included studies, further well-designed RCTs are needed to confirm the add-on effect of herbal bath on psoriasis.

Abstract

Objectives : This study aims to evaluate the add-on effect of herbal bath combined with acitretin in patients with psoriasis. Methods : We searched randomized controlled trials(RCTs) reporting the effect of herbal bath and acitretin combined treatment for psoriasis in 10 electronic databases from their inception to January 2023. Study collection, data extraction, and risk of bias assessment were performed by two independent researchers. Data synthesis and risk of bias evaluation was conducted using Revman 5.4. Results : Ten RCTs with 1,008 subjects were included. Herbal bath and acitretin combined treatment group showed higher average total effective rate than acitretin alone group(RR 1.39; 95% CI: 1.15-1.68, P=0.0006, I 2=0%). Herbal bath and additional treatments such as phototherapy(NB-UVB) and oral herbal medicine, combined with acitretin group also showed higher average total effective rate than acitretin alone group(RR 1.81; 95% CI: 1.47-2.22, P<0.00001, I2=43%). Herbal bath and phototherapy(NB-UVB) combined with acitretin group also showed higher average total effective rate than acitretin alone group(RR 1.51; 95% CI: 1.18-1.93, P=0.0009, I2=0%). The overall risk of bias of the included studies was unclear or of high risks. Conclusions : This review showed that the add-on of herbal bath combined with acitretin treatment could be more effective than acitretin alone treatment in patients with psoriasis. However, because of few included studies, heterogeneity between studies, and insufficient quality of included studies, further well-designed RCTs are needed to confirm the add-on effect of herbal bath on psoriasis.

참고문헌 (49)

  1. Greb JE, "Psoriasis(Primer)", pp.1~18 (2016), Nature Reviews : Disease Primers
  2. Rendon A, "Psoriasis Pathogenesis and Treatment", International Journal of Molecular Sciences, 20(6), pp.1~28 (2019)
  3. Krueger G, "The Impact of Psoriasis on Quality of Life : Results of a 1998 National Psoriasis Foundation Patient-Membership Survey", Archives of Dermatology, 137(3), pp.280~284 (2001)
  4. Jensen P, "Psoriasis and Obesity", DERMATOLOGY, 232(6), pp.633~639 (2017)
  5. Zhu B, "Treatments in psoriasis : from standard pharmacotherapy to nanotechnology therapy", Postepy Dermatol Alergol, 39(3), pp.460~471 (2022)
  6. Diaz BV, "Regulation of vascular endothelial growth factor expression in human keratinocytes by retinoids", J Biol Chem, 275(1), pp.642~650 (2000)
  7. Kaushik SB, "Review of safety and efficacy of approved systemic psoriasis therapies", Int J Dermatol, 58(6), pp.649~658 (2019)
  8. Liu H, "The observed of clinical curative effect of traditional Chinese medicine bath combined with narrow spectrum UVB radiation in the treatment of psoriasis vulgaris", Shijiazhuang:The Fifth Annual Conference of Dermatology Branch of Chinese Society of Chinese Medicine, pp.176~178 (2008)
  9. Lei H, "A systematic review and meta-analysis on the efficacy and safety of traditional Chinese medicine bath in the treatment of psoriasis vulgaris", Annals of Palliative Medicine, 10(10), pp.10674~10683 (2021)
  10. Yu JJ, "Add-on effect of chinese herbal medicine bath to phototherapy for psoriasis vulgaris : a systematic review", Evid Based Complement Alternat Med, 2013, pp.1~14 (2013)
  11. Zhao X, "Effect of traditional Chinese medicine bath combined with Avi A on psoriasis vulgaris", Medical research and education, 27(3), pp.66~ (2010)
  12. Wang J, "Therapeutic effect of traditional Chinese medicine bath combined with narrowband UVB on psoriasis", Medical Journal of West China, 22(12), pp.2304~ (2010)
  13. Luo L, "Clinical observation on treatment of psoriasis vulgaris with narrow spectrum medium wave ultraviolet", Guiding Journal of Traditional Chinese Medicine and Pharmacy, 16(12), pp.52~ (2010)
  14. Cheng L, "Clinical observation on moderate and severe psoriasis vulgaris treated by traditional Chinese medicine bath", Guangming Journal of Chinese Medicine, 26(5), pp.938~940 (2011)
  15. Yu M, "Treatment of psoriasis with western medicine 39 cases", Shaanxi Journal of Traditional Chinese Medicine, 34(2), pp.192~194 (2013)
  16. Geng Q, "Clinical observation of 40 cases of psoriasis psoriasis treated with Avei A capsule and traditional Chinese medicine bath", Henan Traditional Chinese Medicine, 33(3), pp.391~ (2013)
  17. Yu M, "Ave A and carbotriol combined with traditional Chinese medicine bath for 68 cases of psoriasis vulgaris", China Pharmaceuticals, 23(12), pp.104~ (2014)
  18. Hao W, "Observation on the curative effect of traditional Chinese medicine bath combined with Jiedu Huayu decoction on generalized plaques psoriasis", Journal of Taishan Medical College, 36(7), pp.768~770 (2015)
  19. Zhao W, "Observation of 54 cases of psoriasis vulgaris treated with narrow spectrum medium wave ultraviolet", Guide to Chinese Medicine, 14(22), pp.203~ (2016)
  20. Fu F, "Clinical observation on treatment of psoriasis with Avi A combined with traditional Chinese medicine bath", Clinical Journal of Traditional Chinese Medicine, 32(1), pp.156~159 (2020)
  21. Sterne JA, "Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials", Bmj, 342, pp.d4002~ (2011)
  22. Campanati A, "Psoriasis as an immune-mediated and inflammatory systemic disease : from pathophysiology to novel therapeutic approaches", Biomedicines, 9(11), pp.1~20 (2021)
  23. Yu JJ, "Add-on effect of chinese herbal medicine bath to phototherapy for psoriasis vulgaris : a systematic review", Evid Based Complement Alternat Med, 2013, pp.1~15 (2013)
  24. 권혜진, "피부표면온도가 유효물질 경피 흡수 및 피부 상태변화에 미치는 영향", 한국응용과학기술학회지, 36(1), pp.299~304 (2019), 한국응용과학기술학회
  25. Cacciapuoti S, "The Role of Thermal Water in Chronic Skin Diseases Management : A Review of the Literature", J Clin Med, 9(9), pp.1~19 (2020)
  26. Moini JA, "Efficacy of hydrotherapy, spa therapy, and balneotherapy for psoriasis and atopic dermatitis : a systematic review", Int J Dermatol, 62(2), pp.177~189 (2023)
  27. Boreham DR, "Water bath hyperthermia is a simple therapy for psoriasis and also stimulates skin tanning in response to sunlight", Int J Hyperthermia, 11(6), pp.745~754 (1995)
  28. Li JJ, "Phytochemistry and biological properties of isoprenoid flavonoids from Sophora flavescens Ait", Fitoterapia, 143, pp.1~6 (2020)
  29. Khairy H, "Therapeutic efficacy of osthole against dinitrobenzene sulphonic acid induced-colitis in rats", Biomedicine & Pharmacotherapy, 100, pp.42~51 (2018)
  30. Yang D, "Effects of Osthole on the Proliferation. Cell Cycle and Apoptosis in Human Breast Cancer Cells", J Nanjing Norm Univ, 33, pp.76~80 (2010)
  31. Yang B, "Decoction of Dictamnus Dasycarpus Turcz. Root bark ameliorates skin lesions and inhibits inflammatory reactions in mice with contact dermatitis", Pharmacognosy Magazine, 13(51), pp.483~487 (2017)
  32. Xiao DME, "Danshen : a phytochemical and pharmacological overview", Chin J Nat Med, 17(1), pp.59~80 (2019)
  33. Guo Z, "Chinese herbal bath therapy for the treatment of Atopic dermatitis in children : A meta-analysis and systematic review", Medicine, 101(47), pp.1~8 (2022)
  34. Guenther LC, "Acitretin Use in Dermatology", Journal of Cutaneous Medicine and Surgery, 21(3), pp.2~12 (2017)[DOI]
  35. 정성희, "구강점막에서 약물의 직접적용을 위한 연구", Journal of Oral Medicine and Pain, 35(4), pp.229~235 (2010), 대한안면통증∙구강내과학회
  36. Menter A, "Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies", Journal of the American Academy of Dermatology, 82(6), pp.1445~1486 (2020)
  37. Sun Z, "Observation on the clinical curative effect of traditional Chinese medicine bath combined with narrow-band ultraviolet radiation in the treatment of psoriasis vulgaris", Contemporary Medicine, 16, pp.152~ (2010)
  38. Brożyna AA, "Vitamin D Signaling in Psoriasis : Pathogenesis and Therapy", International Journal of Molecular Sciences, 23(15), pp.1~23 (2022)
  39. Balato A, "Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid", Archives of Dermatological Research, 305(3), pp.255~262 (2013)
  40. Chen Z, "Interleukin-33 alleviates psoriatic inflammation by suppressing the T helper type 17 immune response", Immunology, 160(4), pp.382~392 (2020)
  41. Yi L, "Efficacy and safety of external application of Chinese herbal medicine for psoriasis vulgaris : a systematic review of randomized controlled trials", J Tradit Chin Med, 42(4), pp.493~504 (2022)
  42. Spuls PI, "Retrospective study of the efficacy of narrowband UVB and acitretin", J Dermatolog Treat, 14(2), pp.17~20 (2003)
  43. Kampitak T, "UVB(TL-01)and Acitretin vs Narrowband UVB Alo, in Plaque-Type Psoriasis : A Retrospective Study", J Med Assoc Thai, 89(3), pp.S20~4 (2006)
  44. Yang XY, "Chinese Medicine as Supporting Therapy for Psoriasis : Past, Present, and Future", Chin J Integr Med, 29(3), pp.280~288 (2023)
  45. Dai D, "Evidence and potential mechanisms of traditional Chinese medicine for the treatment of psoriasis vulgaris : a systematic review and meta-analysis", J Dermatolog Treat, 33(2), pp.671~681 (2022)
  46. Zhang CS, "Is Oral Chinese Herbal Medicine Beneficial for Psoriasis Vulgaris? A Meta-Analysis of Comparisons with Acitretin", J Altern Complement Med, 22(3), pp.174~188 (2016)
  47. Zhang J, "Benefits and Safety of Chinese Herbal Medicine in Treating Psoriasis : An Overview of Systematic Reviews", Front Pharmacol, 12, pp.1~15 (2021)
  48. Ihtatho D, "Area Assessment of Psoriasis Lesion for PASI Scoring", 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp.3446~3449 (2007)
  49. Romero IB, "Therapeutic goals and treatment response evaluation in moderate to severe psoriasis : an experts opinion document", Annals of Medicine, 53(1), pp.1727~1736 (2021)

관련 논문AI추천

건선의 한약치료 효과에 대한 체계적 문헌 고찰과 메타 분석노석선, 류덕선, 류덕현대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2017 · 제30권 제3호온천요법의 피부질환 치료 효과: 체계적 문헌고찰고미미, 우종민, 유하나, 이선희, 장수빈, 정지연대한예방한의학회 · 대한예방한의학회지2025 · 제29권 제1호면역학적 이해를 통한 건선의 한약 치료 고찰남혜진, 박신영, 박혜리, 임유라, 조준범대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2023 · 제36권 제3호건선 한약제제 임상시험 가이드라인 개발을 위한 관련 국내외 가이드라인과 기존 건선치료 한약제제 연구와의 비교강세현, 김규석, 김윤범, 남혜정, 문영균, 이준희, 정우열대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2016 · 제29권 제2호건선의 한의학적 치료에 관한 논문 경향 분석 - 국내 논문을 중심으로홍석훈대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2013 · 제26권 제4호Efficacy of Herbal Medicines for the Treatment of Seborrheic Dermatitis : Systematic Review김정윤, 김혜경, 임승환, 장영우대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2018 · 제31권 제3호

이 간행물의 다른 논문 (8건)

2018-2022년 경희대학교 한방병원 한방 피부과 외래환자에 대한 통계적 분석김규석, 남혜정, 김윤범, 홍예은, 김병현, 서광일pp. 1-11침, 경피전기자극의 이명 치료에 대한 문헌 고찰 - 자율신경을 중심으로 -이은경, 고혜연, 김민희pp. 12-26대상포진후신경통의 한방 치료 국내 연구 현황 : 증례 연구 분석김지희, 윤화정pp. 27-41화상 및 후유증의 보완 대체 의학 치료 : 무작위 대조 시험에 대한 주제범위 문헌고찰강병수, 최정화, 김종한, 박수연, 정민영, 윤석영pp. 42-73면역학적 이해를 통한 건선의 한약 치료 고찰박혜리, 조준범, 남혜진, 임유라, 박신영pp. 99-118
원문 보기