뇌 대사물질 팬텀을 이용한 뇌의 자기공명 온도측정법에 관한 기초 연구
Preliminary Study on Magnetic Resonance Temperature Measurement using Brain-Metabolite Phantom
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초록
In this study, we measured the chemical shift change of metabolite peaks in the brain-metabolite phantom according to the temperature variation using nuclear magnetic resonance(NMR). The temperature range in NMR system was controled from 25℃ to 80℃(5℃ step) by internal temperature controller. Temperature coefficients of each metabolite peaks were also calculated from the measured chemical shift depending on the temperature. The chemical shift changes depending on temperature were validated by linear regression method for each metabolite peaks. The temperature coefficients of totCr, Cho, Cr, NAA, and Lac were 0.0086, 0.0088, 0.0091, 0.0089, and 0.0088ppm/℃, respectively. This study shows that chemical shift change of brain metabolite and temperature variation have linear relationship each other. This also makes authors believe that brain temperature measurement is possible using MR spectroscopic imaging technique.
Abstract
In this study, we measured the chemical shift change of metabolite peaks in the brain-metabolite phantom according to the temperature variation using nuclear magnetic resonance(NMR). The temperature range in NMR system was controled from 25℃ to 80℃(5℃ step) by internal temperature controller. Temperature coefficients of each metabolite peaks were also calculated from the measured chemical shift depending on the temperature. The chemical shift changes depending on temperature were validated by linear regression method for each metabolite peaks. The temperature coefficients of totCr, Cho, Cr, NAA, and Lac were 0.0086, 0.0088, 0.0091, 0.0089, and 0.0088ppm/℃, respectively. This study shows that chemical shift change of brain metabolite and temperature variation have linear relationship each other. This also makes authors believe that brain temperature measurement is possible using MR spectroscopic imaging technique.
참고문헌 (24)
- Carter DL, "Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma", Int J Radiat Oncol Biol Phys, 40, pp.815~822 (1998)
- Denis de Senneville B, "Magnetic resonance temperature imaging", Int J Hyperthermia, 21, pp.515~531 (2005)
- Ishihara Y, "A precise and fast temperature mapping method using water proton chemical shift", Proceedings of the 11th Annual Meeting of SMRM, Berlin, pp.4803~ (1992)
- N.Mcdannold, "Quantitative MRI-based temperature mapping based on the proton resonant frequency shift:Review of validation studies", IntJ.Hyperthermia, 21(6), pp.533~546 (2005)
- Young IR, "An evaluation of the effects of susceptibility change on water chemical shift method of temperature measurement in human peripheral muscle", Magn Reson Med, 36, pp.366~374 (1996)
- Poorter JDE, "Non-invasive MRI thermometry with the proton resonance frequency shift (PRF) method: In vivo results in human muscle", Magn Reson Med, 33, pp.74~81 (1995)
- K. Kuroda, "Temperature Mapping Using the Water Proton Chemical Shift: Self-Referenced Method With Echo-Planar Spectroscopic Imaging", Magn Reson Med, 43, pp.220~225 (2000)
- Kuroda K, "Temperature mapping using the water proton chemical shift: a chemical shift selective phase mapping (CSSPM) method", Magn Reson Med, 38, pp.845~851 (1997)
- Moriaty JA, "Kucharczyk W. MRI monitoring of interstitial microwave-induced heating and thermal lesions in rabbit brain in vivo", J Magn Reson Imag, 8, pp.128~135 (1998)
- Kahn T, "In vivo MRI thermometry using a phase-sensitive sequence: preliminary experience during MRI-guided laser-induced interstitial thermotherapy of brain tumors", J Magn Reson Imag, 8, pp.160~164 (1998)
- Kettenbach J, "Monitoring and visualization technique for MR-guided laser ablation in an open MR system", J Magn Reson Imag, 8, pp.933~943 (1998)
- Stollberger R, "Influence of the temperature dependent susceptibility on monitoring of interstitial tissue coagulation using the proton resonance frequency method", Proceedings of the 5th Annual Meeting of the ISMRM, pp.1963~ (1997)
- de Zwart JA, "Fast lipid suppressed temperature mapping for the monitoring of focused ultrasound heated tissue", Proceedings of the 6th Annual Meeting of ISMRM, pp.350~ (1998)
- Olsen TS, "Therapeutic hypothermia for acute stroke", Lancet Neurol, 2, pp.410~416 (2003)
- Reith J, "Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome", Lancet, 347, pp.422~425 (1996)
- Castillo J, "Timing for fever-related brain damage in acute ischemic stroke", Stroke, 29, pp.2455~2460 (1998)
- Ian Marshall, "Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke", Magn Reson Imaging, 24, pp.699~706 (2009)
- Daiya Ishigaki, "Brain Temperature Measured Using Proton MR Spectroscopy Detects Cerebral Hemodynamic Impairment in Patients With Unilateral Chronic Major Cerebral Artery Steno-Occlusive Disease Comparison With Positron Emission Tomography", Stroke, 40, pp.3012~3016 (2009)
- Cady EB, "The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy", Magn Reson Med, 33, pp.862~867 (1995)
- Corbett RJ, "Validation of a noninvasive method to measure brain temperature in vivo using 1H NMR spectroscopy", J Neurochem, 64, pp.1224~1230 (1995)
- 우동철, "자기공명분광법에서 TE와 Voxel 내의 대사물질 양에 따른 스펙트럼 변화 평가에 관한 연구", 의학물리, 18(3), pp.179~185 (2007), 한국의학물리학회
- 白文煐, "단위용적 및 다용적 기법 자기공명분광 신호처리 분석 소프트웨어의 개발", 전자공학회논문지 - SP, 39(9), pp.68~79 (2002), 대한전자공학회
- Germain D, "Saint-Jalmes H. MR monitoring of tumour thermal therapy", Magn Reson Materials Phys Biol Med (MAGMA), 13, pp.47~59 (2001)
- 우동철, "개의 뇌 조직로부터 추출한 대사물질의 절대농도 측정 및 평가: 500 MHz 고자장 핵자기공명분광법을 이용한 예비연구결과", 대한자기공명의과학회지, 12(2), pp.100~106 (2008), 대한자기공명의과학회