공포반응실험을 통한 [F-18]FDG 소동물 양전자단층촬영 기능뇌영상 평가
The evaluation of [F-18]FDG small animal PET as a functional neuroimaging technique with fear response experiment
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초록
Although recent studies have shown the usibility of [F-18]FDG small animal Positron Emission Tommography (PET) as a functional neuroimaging technique in behavioural small animal study, researches showing the detection power of functional changes in the brain are still limited. Thus, in the study, we performed [F-18]FDG small animal PET neuroimaging in the well-established fear behavioural experiment. Twelve rats were exposed on cat for 30 minutes after the [F-18]FDG injection. As a result, the brain activity in bilateral amygdala areas significantly increased in the fear condition. In addition, the fear condition evoked the functional activities of hypothalamus, which seemed to be related to the response to stress. These clear localization of fear related brain regions may reflect that a functional neuroimaging technique using [F-18]FDG small animal PET has functional detectibility enough to be applied in small animal behavioral research.
Abstract
Although recent studies have shown the usibility of [F-18]FDG small animal Positron Emission Tommography (PET) as a functional neuroimaging technique in behavioural small animal study, researches showing the detection power of functional changes in the brain are still limited. Thus, in the study, we performed [F-18]FDG small animal PET neuroimaging in the well-established fear behavioural experiment. Twelve rats were exposed on cat for 30 minutes after the [F-18]FDG injection. As a result, the brain activity in bilateral amygdala areas significantly increased in the fear condition. In addition, the fear condition evoked the functional activities of hypothalamus, which seemed to be related to the response to stress. These clear localization of fear related brain regions may reflect that a functional neuroimaging technique using [F-18]FDG small animal PET has functional detectibility enough to be applied in small animal behavioral research.
참고문헌 (16)
- F. Maestu, "Cognition and neural networks, a new perspective based on functional neuroimaging", Rev Neurol, 37, pp.962~966 (2003)
- S. Ogawa, "Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging", Proc Natl Acad Sci USA, 89, pp.5951~5955 (1992)
- A. Van der Linden, "Current status of functional MRI on small animals: application to physiology, pathophysiology, and cognition", NMR Biomed, 20, pp.522~545 (2007)
- R. R. Peeters, "Comparing BOLD fMRI signal changes in the awake and anesthetized rat during electrical forepaw stimulation", Magn Reson Imaging, 19, pp.821~826 (2001)
- FDG micro PET study, "Behav Brain Res", 2009, 43~47
- FDG micro-PET imaging study, "Neurosci Lett", 2009, 60~64
- J. S. Kim, "Performance measurement of the microPET focus 120 scanner", JOURNAL OF NUCLEAR MEDICINE, 48, pp.1527~1535 (2007), SOC NUCLEAR MEDICINE INC
- J.LeDoux, "The emotional brain, fear, and the amygdala", Cell Mol Neurobiol, 23, pp.727~738 (2003)
- J. S. Kim, "Assessment of cerebral glucose metabolism in cat deafness model: Strategies for improving the voxel-based statistical analysis for animal PET studies", Molecular Imaging and Biology, 10(3), pp.154~161 (2008), Elsevier BV
- E. A. Phelps, "Contributions of the amygdala to emotion processing: from animal models to human behavior", Neuron, 48, pp.175~187 (2005)
- W. K. Berg, "Associative learning modifies startle reflexes at the lateral lemniscus", Behav Neurosci, 99, pp.191~199 (1985)
- FDG micro PET imaging study, "NEUROIMAGE", 2009, 1074~1080, pp.ACADEMIC PRESS INC ELSEVIER SCIENCE
- P. Schweinhardt, "a template for spatial normalisation of MR images of the rat brain", J. Neurosci. Methods, 129, pp.105~113 (2003)
- B. J. Fueger, "Impact of animal handling on the results of 18f-FDG Pet studies in mice", J. Nucl. Med, 47, pp.999~1006 (2006)
- A. Valles, "Long-term effects of a single exposure to immobilization: a c-fos mRNA study of the response to the homotypic stressor in the rat brain", J. neurobiol, 66, pp.591~602 (2006)
- M. F. Dallman, "Corticosteroids and the control of function in the hypothalamo-pituitary-adrenal (HPA) axis", Ann. N.Y. Acad. Sci, 746, pp.22~31 (2004)