그레인저 인과성 분석을 이용한 정상인과 수면무호흡증 환자의수면 중 압수용기 반사 효과의 평가
Evaluation of Baroreflex Effectiveness in Normal Subject and Obstructive Sleep Apnea Patient during Sleep using Granger Causality Analysis
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The baroreflex is one kind of homeostatic mechanisms to regulate acute blood pressure (BP) changes bycontrolling heartbeat interval (HBI). To quantify the effect of baroreflex, we suggested a new approach of analyzingGranger causality between systolic BP (SBP) and HBI. The index defined as baroreflex effectiveness (BRE) was generatedby the hypothesis that more effectual baroreflex would be related to more effective Granger causal influenceof SBP on HBI. Six obstructive sleep apnea (OSA) patients (apnea-hypopnea index, AHI ≥ 5 events/hr) and six normalsubjects participated in the study. Their SBP and HBI during nocturnal sleep were obtained from a non-invasive continuousBP measurement device. While the BRE (mean ± SD) of normal subjects was 47.0 ± 4.0%, OSA patientsexhibited the BRE of 34.0 ± 3.8%. The impaired baroreflex function of OSA patients can be explained by the physiologicalmechanism associated with recurrent hypoxic episodes during sleep. Thus, the significantly lower BRE inOSA patients verified the availability of Granger causality analysis to evaluate baroreflex during sleep. Furthermore,the range of BRE obtained from normal subjects was not overlapped with that obtained from OSA patients. It suggeststhe potential of BRE as a new helpful tool for diagnosing OSA.
Abstract
The baroreflex is one kind of homeostatic mechanisms to regulate acute blood pressure (BP) changes bycontrolling heartbeat interval (HBI). To quantify the effect of baroreflex, we suggested a new approach of analyzingGranger causality between systolic BP (SBP) and HBI. The index defined as baroreflex effectiveness (BRE) was generatedby the hypothesis that more effectual baroreflex would be related to more effective Granger causal influenceof SBP on HBI. Six obstructive sleep apnea (OSA) patients (apnea-hypopnea index, AHI ≥ 5 events/hr) and six normalsubjects participated in the study. Their SBP and HBI during nocturnal sleep were obtained from a non-invasive continuousBP measurement device. While the BRE (mean ± SD) of normal subjects was 47.0 ± 4.0%, OSA patientsexhibited the BRE of 34.0 ± 3.8%. The impaired baroreflex function of OSA patients can be explained by the physiologicalmechanism associated with recurrent hypoxic episodes during sleep. Thus, the significantly lower BRE inOSA patients verified the availability of Granger causality analysis to evaluate baroreflex during sleep. Furthermore,the range of BRE obtained from normal subjects was not overlapped with that obtained from OSA patients. It suggeststhe potential of BRE as a new helpful tool for diagnosing OSA.
참고문헌 (9)
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