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비정상적 변연계-대뇌피질 연결고리와 자폐스펙트럼 장애: 확산텐서영상 연구

A Diffusion Tensor Imaging Study focused on the connection of thalamus and cortex by the Autism Spectrum Disorder

윤효운|권형진
특수교육재활과학연구소 (The Research Institute for Special Education & Rehabilitation Science)|2017.09|특수교육재활과학연구|제56권 제3호|pp. 33-47|DOI http://dx.doi.org/10.23944/Jsers.2017.09.56.3.3

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참고문헌

키워드

Social Behavior자폐스펙트럼장애사회적 행동Autism Spectrum Disorder확산텐서영상시상Thalamus변연계Diffusion Tensor ImagingLimbic System
주제분류기타사회과학

초록

대표적인 사회적 행동 장애 질환인 자폐아동들의 두뇌 기능 측면이 아닌 두뇌 각 부위간의 연결고리의 비정상화를 알아보기 위해 연구가 진행되었다. 이를 위해 유사한 연령 및 성별의 일반아동들을 비교군으로 하여 실험을 진행하였다. 자폐아동의 뇌기능 혹은 뇌부위의 비정상적인 발달등과 같은 특징들을 골고루 설명할 수 있는 논리는 뇌부위의 연결고리 혹은 네트워크에 대한 이해라고 할 수 있는데 이를 가장 잘 설명할 수 있는 확산텐서영상법을 사용하였다. 결과로는 자폐아동은 시상부위의 분획이방성(FA) 수치가 일반아동에 비해 낮아 시상으로 시작하여 다른 대뇌피질로 연결되는 망체계가 튼튼하지 않다고 여겨진다. 이는 외부로부터 유입되는 다수의 정보처리 기능과도 밀접한 관계가 있으며, 특히 자폐아들은 사회적 정보처리에 미숙함을 나타낸다고 할 수 있다.

Abstract

The present paper aims to investigate the brain abnormalities in children with autism spectrum disorder in terms of the brain area connectivity. The ASD children from 9 to 14 years were recruited and the normal children at the same age as control. In order to measure brain area connectivity in non-invasive way, the diffusion tensor imaging technique was used. This technique is regarded in addition to functional MRI other powerful tool to measure the brain function as well as the connectivity. As results, the fractional anisotropy value of ASD children in thalamus area is significantly lower to the normal children. This leads to a conclusion that the connection between thalamus and iso-cortex in ASD children is weaker than the normal, which also means the lack of information processing, especially if it includes social cue.

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