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Characteristics of Cerebral Microbleeds

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초록

Cerebral microbleeds (CMBs) are increasingly recognized neuroimaging findings, occurring with cerebrovascular disease, dementia, and aging. CMBs are associated with subsequent hemorrhagic and ischemic stroke, and also with an increased risk of cognitive deterioration and dementia. They occur in the setting of impaired small vessel integrity due to hypertension or cerebral amyloid angiopathy. This review summarizes the concepts, cause or risk factors, histopathological mechanisms, and clinical consequences of CMBs.

Abstract

Cerebral microbleeds (CMBs) are increasingly recognized neuroimaging findings, occurring with cerebrovascular disease, dementia, and aging. CMBs are associated with subsequent hemorrhagic and ischemic stroke, and also with an increased risk of cognitive deterioration and dementia. They occur in the setting of impaired small vessel integrity due to hypertension or cerebral amyloid angiopathy. This review summarizes the concepts, cause or risk factors, histopathological mechanisms, and clinical consequences of CMBs.

참고문헌 (56)

  1. Roob G, "MRI evidence of past cerebral microbleeds in a healthy elderly population", Neurology, 52, pp.991~994 (1999)
  2. Greenberg SM, "Cerebral microbleeds: a guide to detection and interpretation", Lancet Neurol, 8, pp.165~174 (2009)
  3. Poels MM, "Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study", Stroke, 42, pp.656~661 (2011)
  4. Sveinbjornsdottir S, "Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location", J Neurol Neurosurg Psychiatry, 79, pp.1002~1006 (2008)
  5. Vernooij MW, "Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study", Neurology, 70, pp.1208~1214 (2008)
  6. Poels MM, "Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study", Stroke, 41, pp.S103~S106 (2010)
  7. Akoudad S, "Association of cerebral microbleeds with cognitive decline and dementia", JAMA Neurol, 73, pp.934~943 (2016)
  8. Seo SW, "Clinical significance of microbleeds in subcortical vascular dementia", Stroke, 38, pp.1949~1951 (2007)
  9. Cordonnier C, "Brain microbleeds and Alzheimer's disease: innocent observation or key player?", Brain, 134, pp.335~344 (2011)
  10. Koennecke HC, "Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications", Neurology, 66, pp.165~171 (2006)
  11. Lovelock CE, "Edinburgh Stroke Study Group Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: a systematic review of published and unpublished studies", Stroke, 41, pp.1222~1228 (2010)
  12. Wilson D, "Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: a meta-analysis", Neurology, 87, pp.1501~1510 (2016)
  13. 박미영, "자화율강조영상을 이용한 알츠하이머병과 뇌경색 환자의 뇌미세출혈 분포 분석", 대한신경과학회지, 35(2), pp.72~79 (2017), 대한신경과학회[DOI]
  14. Akoudad S, "Cerebral microbleeds and the risk of mortality in the general population", Eur J Epidemiol, 28, pp.815~821 (2013)
  15. Peng Q, "Longitudinal relationship between chronic kidney disease and distribution of cerebral microbleeds in patients with ischemic stroke", J Neurol Sci, 362, pp.1~6 (2016)
  16. Wardlaw JM, "Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration", Lancet Neurol, 12, pp.822~838 (2013)
  17. Shoamanesh A, "Cerebral microbleeds: histopathological correlation of neuroimaging", Cerebrovasc Dis, 32, pp.528~534 (2011)
  18. Al-Shahi Salman R, "Hemorrhage from cavernous malformations of the brain: definition and reporting standards", Stroke, 39, pp.3222~3230 (2008)
  19. Gaviani P, "Improved detection of metastatic melanoma by T2*-weighted imaging", AJNR Am J Neuroradiol, 27, pp.605~608 (2006)
  20. Nandigam RN, "MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength", AJNR Am J Neuroradiol, 30, pp.338~343 (2009)
  21. Haller S, "Cerebral microbleeds: imaging and clinical significance", Radiology, 287, pp.11~28 (2018)
  22. Haacke EM, "Imaging cerebral amyloid angiopathy with susceptibility-weighted imaging", AJNR Am J Neuroradiol, 28, pp.316~317 (2007)
  23. Cheng AL, "Susceptibility-weighted imaging is more reliable than T2*-weighted gradient-recalled echo MRI for detecting microbleeds", Stroke, 44, pp.2782~2786 (2013)
  24. Seghier ML, "Microbleed detection using automated segmentation (MIDAS): a new method applicable to standard clinical MR images", PLoS One, 6, pp.e17547~ (2011)
  25. Kuijf HJ, "Semi-automated detection of cerebral microbleeds on 3.0 T MR images", PLoS One, 8, pp.e66610~ (2013)
  26. Gregoire SM, "The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds", Neurology, 73, pp.1759~1766 (2009)
  27. Cordonnier C, "improving interrater agreement about brain microbleeds: development of the Brain Observer MicroBleed Scale (BOMBS)", Stroke, 40, pp.94~99 (2009)
  28. Qiu C, "Differential associations between retinal signs and CMBs by location: the AGES-Reykjavik Study", Neurology, 90, pp.e142~e148 (2018)
  29. Granger JP, "An emerging role for inflammatory cytokines in hypertension", Am J Physiol Heart Circ Physiol, 290, pp.H923~H924 (2006)
  30. Shoamanesh A, "Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study", Neurology, 84, pp.825~832 (2015)
  31. Fisher M., "Cerebral microbleeds and thrombolysis: clinical consequences and mechanistic implications", JAMA Neurol, 73, pp.632~635 (2016)
  32. Jeon SB, "Initial microbleeds at MR imaging can predict recurrent intracerebral hemorrhage", J Neurol, 254, pp.508~512 (2007)
  33. Vergouwen MD, "Statin treatment and the occurrence of hemorrhagic stroke in patients with a history of cerebrovascular disease", Stroke, 39, pp.497~502 (2008)
  34. Hackam DG, "Statins and intracerebral hemorrhage: collaborative systematic review and meta-analysis", Circulation, 124, pp.2233~2242 (2011)
  35. Oh MY, "Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds", BMC Neurol, 14, pp.127~ (2014)
  36. Yates PA, "Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations", Front Neurol, 4, pp.205~ (2014)
  37. Lee SH, "Dynamic temporal change of cerebral microbleeds: long-term follow-up MRI study", PLoS One, 6, pp.e25930~ (2011)
  38. McCarron MO, "The apolipoprotein E ε2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage", J Neuropathol Exp Neurol, 58, pp.711~718 (1999)
  39. Greenberg SM, "Microbleeds versus macrobleeds: evidence for distinct entities", Stroke, 40, pp.2382~2386 (2009)
  40. Wang Z, "Cerebral microbleeds: is antithrombotic therapy safe to administer?", Stroke, 45, pp.2811~2817 (2014)
  41. Pasi M, "Mixed-location cerebral hemorrhage", microbleeds: underlying microangiopathy and recurrence risk, 2018, pp.90, e119~e126
  42. Charidimou A, "MRI-visible perivascular spaces in cerebral amyloid angiopathy and hypertensive arteriopathy", Neurology, 88, pp.1157~1164 (2017)
  43. Martinez-Ramirez S, "Topography of dilated perivascular spaces in subjects from a memory clinic cohort", Neurology, 80, pp.1551~1556 (2013)
  44. Renard D., "Cerebral microbleeds: a magnetic resonance imaging review of common and less common causes", Eur J Neurol, 25, pp.441~450 (2018)
  45. Unetani H, "Prevalence and topography of small hypointense foci suggesting microbleeds on 3T susceptibility-weighted imaging in various types of dementia", AJNR Am J Neuroradiol, 34, pp.984~989 (2013)
  46. Kato H, "Silent cerebral microbleeds on T2*-weighted MRI: correlation with stroke subtype, stroke recurrence, and leukoaraiosis", Stroke, 33, pp.1536~1540 (2002)
  47. Imaizumi T, "Dotlike hemosiderin spots on T2*-weighted magnetic resonance imaging as a predictor of stroke recurrence: a prospective study", J Neurosurg, 101, pp.915~920 (2004)
  48. Bokura H, "Microbleeds are associated with subsequent hemorrhagic and ischemic stroke in healthy elderly individuals", Stroke, 42, pp.1867~1871 (2011)
  49. van Etten ES, "Incidence of symptomatic hemorrhage in patients with lobar microbleeds", Stroke, 45, pp.2280~2285 (2014)
  50. Soo YO, "Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds", J Neurol, 255, pp.1679~1686 (2008)
  51. Altmann-Schneider I, "Cerebral microbleeds are predictive of mortality in the elderly", Stroke, 42, pp.638~644 (2011)
  52. Zhu YC, "Distribution of white matter hyperintensity in cerebral hemorrhage and healthy aging", J Neurol, 259, pp.530~536 (2012)
  53. Liu W, "Different impacts of blood pressure variability on the progression of cerebral microbleeds and white matter lesions", Stroke, 43, pp.2916~2922 (2012)
  54. Schuur M, "Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population", J Neurol Neurosurg Psychiatry, 82, pp.41~44 (2011)
  55. Selim M, "Atrial fibrillation and microbleeds", Stroke, 48, pp.2660~2664 (2017)
  56. Greenberg SM, "Alzheimer disease's double-edged vaccine", Nat Med, 9, pp.389~390 (2003)

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