Cognitive Outcomes 3 Months after Unilateral Carotid Stenting : A Preliminary study
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Background: Percutaneous transluminal angioplasty with stenting (PTAS) has become a treatment option for severe carotid stenosis. The goal of our study was to determine retrospectively neurocognitive outcome 3 months after unilateral stent-protected carotid angioplasty. Methods: Nine patients who underwent stent-protected angioplasty for symptomatic(n=7) or asymptomatic(n=2) high grade carotid stenosis were investigated. Patients were performed pre-stenting MRI, and the neuropsychological tests were performed both before and 3 month after stent placement. Results: Three months after stenting, we found no change or deterioration of cognitive outcomes in 5 of 9 patients (55%) and prominent cognitive improvement in 4 of 9 patients (45%) for memory, visuospatial function, and frontal executive function. Conclusions: Our study showed that 3 months after PTAS cognitive functioning did not change in most patients significantly. For some patients, however, significant improvement were confirmed in clinical and in neuropsychological test. The reasons for these differences are unclear, but we suggest that it may depend on variable factor; symptomatic, education, right vs. left and the combined ipsilateral intracranial stenosis.
Abstract
Background: Percutaneous transluminal angioplasty with stenting (PTAS) has become a treatment option for severe carotid stenosis. The goal of our study was to determine retrospectively neurocognitive outcome 3 months after unilateral stent-protected carotid angioplasty. Methods: Nine patients who underwent stent-protected angioplasty for symptomatic(n=7) or asymptomatic(n=2) high grade carotid stenosis were investigated. Patients were performed pre-stenting MRI, and the neuropsychological tests were performed both before and 3 month after stent placement. Results: Three months after stenting, we found no change or deterioration of cognitive outcomes in 5 of 9 patients (55%) and prominent cognitive improvement in 4 of 9 patients (45%) for memory, visuospatial function, and frontal executive function. Conclusions: Our study showed that 3 months after PTAS cognitive functioning did not change in most patients significantly. For some patients, however, significant improvement were confirmed in clinical and in neuropsychological test. The reasons for these differences are unclear, but we suggest that it may depend on variable factor; symptomatic, education, right vs. left and the combined ipsilateral intracranial stenosis.