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정상 노년층, 경도인지장애, 알츠하이머성 치매의 언어 산출 특성

Characteristics of Expressive Language in Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

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초록

Background: As aging influences the incidence of Alzheimer’s disease (AD), it becomes more important to effectively differentiate preclinical from clinical stages of AD. The purpose of this study was to review the literature on characteristics of expressive language in normal aging, mild cognitive impairment (MCI), and AD in light of lexicology/semantics, morphology/syntactics, phonology/articulation, and pragmatics. Methods: A comprehensive literature search identified numerous studies on expressive language in three groups, and we analyzed them according to each domain. Results: The results indicated that the lexicology/semantics in both spontaneous speech and naming tasks could aid on the differential diagnosis of three groups. In contrast, there were some controversial views regarding morphology/syntactics and phonology/articulation. Most studies on pragmatics were based on a few cases. Conclusions: These results provide the diagnostic bases that may be used in evaluation and treatment of MCI and AD despite several controversial viewpoints. They also imply that, it is necessary to consider diverse aspects such as diagnostic tools of lexicology/semantics, discourse, and functional communication.

Abstract

Background: As aging influences the incidence of Alzheimer’s disease (AD), it becomes more important to effectively differentiate preclinical from clinical stages of AD. The purpose of this study was to review the literature on characteristics of expressive language in normal aging, mild cognitive impairment (MCI), and AD in light of lexicology/semantics, morphology/syntactics, phonology/articulation, and pragmatics. Methods: A comprehensive literature search identified numerous studies on expressive language in three groups, and we analyzed them according to each domain. Results: The results indicated that the lexicology/semantics in both spontaneous speech and naming tasks could aid on the differential diagnosis of three groups. In contrast, there were some controversial views regarding morphology/syntactics and phonology/articulation. Most studies on pragmatics were based on a few cases. Conclusions: These results provide the diagnostic bases that may be used in evaluation and treatment of MCI and AD despite several controversial viewpoints. They also imply that, it is necessary to consider diverse aspects such as diagnostic tools of lexicology/semantics, discourse, and functional communication.

참고문헌 (94)

  1. Reisberg B, "The global deterioration scale for assessment of primary degenerative dementia", Am J Psychiatry, 139, pp.1136~1139 (1982)
  2. Petersen, RC, "Tangalos EG, Kokmen E. Mild cognitive impairment: Clinical characterization and outcome", Arch Neurol, 56, pp.303~308 (1999)
  3. Hughes CP, "A new clinical scale for the staging of dementia", Br J Psychiatry, 140, pp.566~572 (1982)
  4. Morris JC, "Mild cognitive impairment represents early-stage Alzheimer disease", Arch Neurol, 58, pp.397~405 (2001)
  5. Winblad B, "Mild cognitive impairment-beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment", J Intern Med, 256, pp.240~246 (2004)
  6. Portet F, "What is a mild cognitive impairment", Rev Prat, 55, pp.1891~1894 (2005)
  7. Saxton J, "Preclinical Alzheimer disease: Neuropsychological test performance 1.5 to 8 years prior to onset", Neurology, 63, pp.2341~2347 (2004)
  8. Alexopoulos P, "Progression to dementia in clinical subtypes of mild cognitive impairment", Dement Geriatr Cogn Disord, 22, pp.27~34 (2006)
  9. Tierney MC, "Neuropsychological test accurately predict incident Alzheimer disease after 5 and 10 years", Neurology, 64, pp.1853~1859 (2005)
  10. Petersen RC, "Current concepts in mild cognitive impairment", Arch Neurol, 58, pp.1985~1992 (2001)
  11. Hough MS, "Incidence of word finding deficits in normal aging", Folia Phoniatr Logop, 59, pp.10~19 (2007)
  12. Lonie JA, "Lexical and semantic fluency discrepancy scores in aMCI and early Alzheimer’s disease", J Neuropsychol, 3(1), pp.79~92 (2009)
  13. Henry JD, "Verbal fluency performance in dementia of the Alzheimer’s type: A meta-analysis", Neuropsychologia, 42, pp.1212~1222 (2004)
  14. Karrasch M, "The diagnostic accuracy of an incidental memory modification of the Boston Naming Test (memo-BNT) in differentiating between normal aging and mild Alzheimer’s disease", Clin Neuropsychol, 24, pp.1355~1364 (2010)
  15. Hoyte KJ, "Components of speech prosody and their use in detection of syntactic structure by older adults", Exp Aging Res, 35, pp.129~151 (2009)
  16. Kemper S, "Sentence production by young and older adults in controlled contexts", J Gerontol, 59, pp.220~224 (2004)
  17. Davidson DJ, "Age preservation of the syntactic processor in production", J Psycholinguist Res, 32, pp.541~566 (2003)
  18. Kavé G, "Morphology in picture descriptions provided by persons with Alzheimer’s disease", J Speech Lang Hear Res, 46, pp.341~352 (2003)
  19. Cooper PV, "Discourse production and normal aging: Performance on oral picture description tasks", J Gerontol, 45, pp.210~214 (1990)
  20. Forbes-McKay KE, "Detecting subtle spontaneous language decline in early Alzheimer’s disease with a picture description task", Neurol Sci, 26, pp.243~254 (2005)
  21. Mitchell AJ, "Is it time to separate subjective cognitive complaints from the diagnosis of mild cognitive impairment", Age Ageing, 37, pp.497~499 (2008)
  22. Nestor PJ, "Limbic hypometabolism in Alzheimer’s disease and mild cognitive impairment", Ann Neurol, 54, pp.343~351 (2003)
  23. Willers IF, "Subclinical naming errors in mild cognitive impairment: A semantic deficit", Dement Neuropsychol, 2, pp.217~222 (2008)
  24. Bschor T, "Spontaneous speech of patients with dementia of the Alzheimer type and mild cognitive impairment", Int Psychogeriatr, 13, pp.289~298 (2001)
  25. Dudas RB, "Episodic and semantic memory in mild cognitive impairment", Neuropsychologia, 43, pp.1266~1276 (2005)
  26. Fisher NJ, "Neuropsychological subgroups of patients with Alzheimer’s disease: An examination of the first 10 years of CERAD data", J Clin Exp Neuropsychol, 21, pp.488~518 (1999)
  27. Vuorinen E, "Common pattern of language impairment in vascular dementia and in Alzheimer’s disease", Alzheimer Dis Assoc Disord, 14, pp.81~86 (2000)
  28. Venneri A, "Impoverishment of spontaneous language and the prediction of Alzheimer’s disease", Brain, 128, pp.27~ (2005)
  29. Forbes-McKay KE, "Distinct patterns of spontaneous speech deterioration: an early predictor of Alzheimer’s disease", Brain Cogn, 48(2), pp.356~361 (2002)
  30. Hodges JR, "Naming and knowing in dementia of Alzheimer’s type", Brain Lang, 54, pp.302~325 (1996)
  31. Forbes-McKay KE, "The age of acquisition of words produced in a semantic fluency task can reliably differentiate normal from pathological age related cognitive decline", Neuropsychologia, 43, pp.1625~1632 (2005)
  32. Amieva H, "The 9 year cognitive decline before dementia of the Alzheimer type: A prospective population based study", Brain, 128, pp.1093~1101 (2005)
  33. Auriacombe S, "A longitudinal study of qualitative features of category verbal fluency in incident Alzheimer’’s disease subjects: Results from the PAQUID study", Dement Geriatr Cogn Disord, 21, pp.260~266 (2006)
  34. Hodges JR, "Evolution of cognitive deficits and conversion to dementia in patients with mild cognitive impairment: A very long-term follow-up study", Dement Geriatr Cogn Disord, 21, pp.380~391 (2006)
  35. Jorm AF, "Cognitive deficits 3 to 6 years before dementia onset in a population sample: The Honolulu-Asia aging study", J Am Geriatr Soc, 53, pp.452~455 (2005)
  36. Vogel A, "Semantic memory impairment in the earliest phases of Alzheimer’s disease", Dement Geriatr Cogn Disord, 19, pp.75~81
  37. Feyereisen P, "A meta-analytic procedure shows an age-related decline in picture naming: Comments on Goulet, Ska, and Kahn", J Speech Lang Hear Res, 40, pp.1328~1333 (1997)
  38. Weiner MF, "Language in Alzheim er’s disease", J Clin Psychiatry, 69, pp.1223~1227 (2008)
  39. Ahmed S, "Naming of objects, faces and buildings in mild cognitive impairment", Cortex, 44, pp.746~752 (2008)
  40. Koenig P, "Neural basis for motion and cognition verbs", Brain Lang, 69, pp.408~411 (1999)
  41. Grossman M, "Lexical acquisition in probable Alzheimer’s disease", Brain Lang, 60, pp.443~463 (1997)
  42. Kim M, "Verb deficits in Alzheimer’s disease and agrammatism: implications for lexical organization", Brain Lang, 88, pp.1~20 (2004)
  43. Balthazar ML, "Semantic error patterns on the Boston Naming Test in normal aging, amnestic mild cognitive impairment, and mild Alzheimer’s disease: is there semantic disruption", Neuropsychology, 22, pp.703~709 (2008)
  44. Murphy KJ, "Verbal fluency patterns in amnestic mild cognitive impairment are characteristic of Alzheimer’s type dementia", Journal of the International Neuropsychological Society, 12, pp.570~574 (2006)
  45. Bayles KA, "Helm-Estabrooks N, Hawley JN. Verbal perseveration in individuals with Alzheimer’s disease", Seminars in Speech and Language, 25, pp.335~347 (2004)
  46. Cummings JL, "The pattern of reading deterioration in dementia of the Alzheimer type: observations and implications", Brain Lang, 29, pp.315~323 (1986)
  47. Nutter-Upham KE, "Verbal fluency performance in amnestic MCI and older adults with cognitive complaints", Arch Clin Neuropsychol, 23, pp.229~241 (2008)
  48. Delazer M, "Anomia for people names in DAT-evidence for semantic and post-semantic impairments", Neuropsychologia, 41, pp.1593~1598 (2003)
  49. Gollan TH, "Accessibility of the nondominant language in picture naming: A counterintuitive effect of dementia on bilingual language production", Neuropsychologia, 48, pp.1356~1366 (2010)
  50. Cuetos F, "Different variables predict anomia in different subjects: a longitudinal study of two Alzheimer’s patients", Neuropsychologia, 46, pp.249~260 (2008)
  51. Willers IF, "Subclinical naming errors in mild cognitive impairment: a semantic deficit", Dement Neuropsychol, 2, pp.217~222 (2008)
  52. Done DJ, "Attribute verification in dementia of Alzheimer type: Evidence for the preservation of distributed concept knowledge", Cogn Neuropsychol, 14, pp.547~571 (1997)
  53. Balthazar ML, "Coordinated and circumlocutory semantic naming errors are related to anterolateral temporal lobes in mild AD, amnestic mild cognitive impairment, and normal aging", J Int Neuropsychol Soc, 16, pp.1099~1107 (2010)
  54. Kemper S, "Longitudinal change in language production: effects of aging and dementia on grammatical complexity and propositional content", Psychol Aging, 16, pp.600~614 (2001)
  55. Altmann LJP, "Speech errors in Alzheimer’s disease: Reevaluating morphosyntactic preservation", J Speech Lang Hear Res, 44, pp.1069~1082 (2001)
  56. Ferreira VS, "Is it better to give than to donate? Syntactic flexibility in language production", J Mem Lang, 35, pp.724~755 (1996)
  57. Kempler D, "Sentence comprehension deficits in Alzheimer’s disease: A comparison of off-line and on-line sentence processing", Brain Lang, 64, pp.297~216 (1998)
  58. Shenaut GK, "Methodological control of semantic priming in Alzheimer’s disease", Psychol Aging, 11, pp.443~448 (1996)
  59. Rousseaux M, "An analysis of communication in conversation in patients with dementia", Neuropsychologia, 48, pp.3884~3890 (2010)
  60. Grossman N, "An aspect of sentence processing in Alzheimer’s disease: quantifier-noun disagreement", Neurology, 45, pp.85~91 (1995)
  61. DeLisa JA, "Physical Medicine and Rehabilitation. Principles and Practice. 4th ed" (2004), Lippincott Williams & Wilkins
  62. Altmann LJP, "Speech Errors in Alzheimer’s Disease: Reevaluating Morphosyntactic Preservation", J Speech Lang Hear Res, 44, pp.1069~1082 (2001)
  63. Altmann LJP, "Open and closed class speech errors in Alzheimer’s disease", J Int Neuropsychol Soc, 1, pp.148~ (1995)
  64. Cortese MJ, "Consistency and regularity in past-tense verb generation in healthy ageing, Alzheimer’s disease, and semantic dementia", Cogni Neuropsychol, 23, pp.856~876 (2006)
  65. Ullman MT, "A neural dissociation within language: Evidence that the mental dictionary is part of declarative memory, and that grammatical rules are processed by the procedural system", J Cogn Neurosci, 9, pp.266~276 (1997)
  66. Colombo L, "Italian verb inflection in Alzheimer dementia", Neuropsychologia, 47, pp.1069~1078 (2009)
  67. Kemper S, "On the preservation of syntax in Alzheimer’s disease", Arch Neurol, 50, pp.81~86 (1993)
  68. Berent I, "The representation of Hebrew words: Evidence from the obligatory contour principle", Cognition, 64, pp.39~72 (1997)
  69. Müller N, "Order and disorder in conversation: encounters with dementia of the Alzheimer’s type", Clin Linguist Phon, 19, pp.393~404 (2005)
  70. Mendez MF, "Speech and language in progressive nonfluent aphasia compared with early Alzheimer’s disease", Neurology, 61, pp.1108~1113 (2003)
  71. Green J, "Progressive aphasia: A precursor of global dementia", Neurology, 40, pp.423~429 (1990)
  72. Hoffmann I, "Temporal parameters of spontaneous speech in Alzheimer’s disease", Int J Speech Lang Pathol, 12, pp.29~34 (2010)
  73. Croot K, "Phonological and articulatory impairment in Alzheimer’s disease: a case series", Brain Lang, 75, pp.277~309 (2000)
  74. Glosser G, "Cognitive mechanisms for producing nonwords: Evidence from Alzheimer’’s disease", Brain Lang, 63, pp.32~49 (1998)
  75. Glosser G, "Repetition of single words and nonwords in Alzheimer’s disease", Cortex, 33, pp.653~666 (1997)
  76. Weiner MF, "The American Psychiatric Publishing textbook of Alzheimer disease and other dementias", pp.94~96 (2009), American Psychiatric Publishing Inc
  77. Collette F, "Phonological loop and central executive functioning in Alzheimer’s disease", Neuropsychologia, 37, pp.905~918 (1999)
  78. Biassou N, "Phonologic processing deficits in Alzheimer’s disease", Neurology, 45, pp.2165~2169 (1995)
  79. Romero B, "Deterioration of spontaneous speech in AD patients during a 1-year follow-up: homogeneity of profiles and factors associated with progression", Dementia, 7, pp.35~40 (1996)
  80. Patel PG, "The language production system and senile dementia of Alzheimer’s type: neuropathological implications", Aphasiology, 8, pp.1~18 (1994)
  81. Braver TS, "Context processing and context maintenance in healthy aging and early stage dementia of the Alzheimer’s type", Psychol Aging, 20, pp.33~46 (2005)
  82. McDaniel MA, "Aging and maintaining intentions over delays: Do it or lose it", Psychol Aging, 18, pp.823~835 (2003)
  83. Heller RB, "Communicative function in patients with questionable Alzheimer’s disease", Psychol Aging, 7, pp.395~400 (1992)
  84. Perkins L, "Conversing in dementia: A conversation analytic approach", J Neurolinguistics, 11, pp.33~53 (1998)
  85. Müller N, "Collaborative role construction in a conversation with dementia: An application of systemic functional linguistics", Clin Linguist Phon, 22(10), pp.767~774 (2008)
  86. Carlomagno S, "Referential communication in Alzheimer’s type dementia", Cortex, 41, pp.520~534 (2005)
  87. Brandão L, "Cognition and discourse production in Alzheimer’s disease: using informative prompts", Psychol Neurosci, 2, pp.147~155 (2009)
  88. Berrewaerts J, "Langageetdemence: examen des capacities pragmatiquesdans la maladie d’Alzheimer", Revue de Neuropsychol, 13, pp.165~207 (2003)
  89. Perkins MR, "Pragmatic ability and disability as emergent phenomena", Clin Linguist Phon, 19, pp.367~377 (2005)
  90. Taler V, "Language performance in Alzheimer’s disease and mild cognitive impairment: a comparative review", J Clin Exp Neuropsychol, 30, pp.501~556 (2008)
  91. Chapman SB, "Discourse changes in early Alzheimer’s disease, mild cognitive impairment and normal aging", Alzheimer Dis Assoc Disord, 16, pp.177~186 (2002)
  92. Emery VOB, "Language impairment in dementia of the Alzheimer type: a hierarchical decline", Int J Psychiatry Med, 30, pp.145~164 (2000)
  93. Taylor JR, "From amnesia to dementia: ERP studies of memory and language", Clin EEG Neurosci, 38, pp.8~17 (2007)
  94. Olichney JM, "Abnormal verbal event related potentials in mild cognitive impairment and incipient Alzheimer’s disease", J Neurol Neurosurg Psychiatry, 73, pp.377~384 (2002)

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