Corticobasal Degeneration Presenting as Non-Fluent/Agrammatic Primary Progressive Aphasia: A Case Report
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
BackgroundNon-fluent agrammatic primary progressive aphasia (naPPA) is characterized by progressive non-fluent speech disorder and might be associated with taupathy such as corticobasal degeneration (CBD) and progressive supranuclear palsy. We report a case of overlap syndrome presented with language impairment, and diagnosed as naPPA with possible CBD. Case ReportA 58-year-old woman visited a memory and dementia clinic, with a 10-month history of progressive language disturbance. She was diagnosed as naPPA and overlapping CBD, based on the clinical features and neuroimaging findings including florbetaben PET. ConclusionsnaPPA is pathologically caused by taupathy, and might progress to asymmetrical parkinsonism and apraxia, suggestive of CBD. Overlapping clinical features in our case represent various phenotypes of taupathy.
Abstract
BackgroundNon-fluent agrammatic primary progressive aphasia (naPPA) is characterized by progressive non-fluent speech disorder and might be associated with taupathy such as corticobasal degeneration (CBD) and progressive supranuclear palsy. We report a case of overlap syndrome presented with language impairment, and diagnosed as naPPA with possible CBD. Case ReportA 58-year-old woman visited a memory and dementia clinic, with a 10-month history of progressive language disturbance. She was diagnosed as naPPA and overlapping CBD, based on the clinical features and neuroimaging findings including florbetaben PET. ConclusionsnaPPA is pathologically caused by taupathy, and might progress to asymmetrical parkinsonism and apraxia, suggestive of CBD. Overlapping clinical features in our case represent various phenotypes of taupathy.
참고문헌 (11)
- Hardiman O, "Neurodegenerative Disorders", pp.115~117 (2011), Springer
- Grossman M, "The non-fluent", agrammatic variant of primary progressive aphasia, 2012, pp.11, 545~555
- Mesulam MM, "Slowly progressive aphasia without generalized dementia", Ann Neurol, 11, pp.592~598 (1982)
- Kertesz A, "The pathology and nosology of primary progressive aphasia", Neurology, 44, pp.2065~2072 (1994)
- Grimes DA, "Dementia as the most common presentation of cortical-basal ganglionic degeneration", Neurology, 53, pp.1969~1974 (1999)
- Gorno-Tempini ML, "Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome : a case report", Neurocase, 10, pp.426~436 (2004)
- Boeve B, "Progressive nonfluent aphasia and subsequent aphasic dementia associated with atypical progressive supranuclear palsy pathology", Eur Neurol, 49, pp.72~78 (2003)
- Boeve BF, "Parkinson-related dementias", Neurol Clin, 25, pp.761~781 (2007)
- Wenning GK, "Natural history and survival of 14 patients with corticobasal degeneration confirmed at postmortem examination", J Neurol Neurosurg Psychiatry, 64, pp.184~189 (1998)
- Armstrong MJ, "Criteria for the diagnosis of corticobasal degeneration", Neurology, 80, pp.496~503 (2013)
- Gorno-Tempini ML, "Classification of primary progressive aphasia and its variants", Neurology, 76, pp.1006~1014 (2011)