Association of Type 2 Diabetes Mellitus With Perivascular Spaces and Cerebral Amyloid Angiopathy in Alzheimer’s Disease: Insights From MRI Imaging
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Background and Purpose: According to the amyloid cascade hypothesis, fibrillary amyloid-beta load in the brain causes Alzheimer’s disease (AD) with toxic effects. Recently, perivascular spaces (PVSs), fluid-filled cavities around small penetrating arterioles and venules in the brain, and the glymphatic system relationship with type 2 diabetes mellitus (DM2) and AD has been an important research topic from a physiopathological point of view. There are two types of PVSs that are associated with sporadic atherosclerosis and cerebral amyloid angiopathy. In this study, we evaluated the relationship between the number and localization of enlarged PVSs in AD. Methods: A total of 254 patients with AD and 125 healthy controls were included in this study All the patients were evaluated with neurological and cognitive examinations and magnetic resonance imaging (MRI). PVSs on MRI were graded by recording their number and location. The study was a retrospective study. Results: In our study, the number of white matter convexity-central semiovale localized PVSs was higher in patients than in the control group. In addition, the number of PVSs in this localization score was higher in patients with DM2. Cerebral PVS counts were higher in patients with AD than in the control group. Conclusions: These results suggest the important role of cerebral amyloid angiopathy, one of the vascular risk factors, and the glymphatic system in the pathogenesis of AD. In addition, the results of our study suggest that the evaluation of PVSs levels, especially at the (centrum semiovale), using imaging studies in AD is a potential diagnostic option.
Abstract
Background and Purpose: According to the amyloid cascade hypothesis, fibrillary amyloid-beta load in the brain causes Alzheimer’s disease (AD) with toxic effects. Recently, perivascular spaces (PVSs), fluid-filled cavities around small penetrating arterioles and venules in the brain, and the glymphatic system relationship with type 2 diabetes mellitus (DM2) and AD has been an important research topic from a physiopathological point of view. There are two types of PVSs that are associated with sporadic atherosclerosis and cerebral amyloid angiopathy. In this study, we evaluated the relationship between the number and localization of enlarged PVSs in AD. Methods: A total of 254 patients with AD and 125 healthy controls were included in this study All the patients were evaluated with neurological and cognitive examinations and magnetic resonance imaging (MRI). PVSs on MRI were graded by recording their number and location. The study was a retrospective study. Results: In our study, the number of white matter convexity-central semiovale localized PVSs was higher in patients than in the control group. In addition, the number of PVSs in this localization score was higher in patients with DM2. Cerebral PVS counts were higher in patients with AD than in the control group. Conclusions: These results suggest the important role of cerebral amyloid angiopathy, one of the vascular risk factors, and the glymphatic system in the pathogenesis of AD. In addition, the results of our study suggest that the evaluation of PVSs levels, especially at the (centrum semiovale), using imaging studies in AD is a potential diagnostic option.
참고문헌 (34)
- Marín-Padilla M, "Developmental aspects of the intracerebral microvasculature and perivascular spaces : insights into brain response to late-life diseases", J Neuropathol Exp Neurol, 70, pp.1060~1069 (2011)
- Ramirez J, "Imaging the perivascular space as a potential biomarker of neurovascular and neurodegenerative diseases", Cell Mol Neurobiol, 36, pp.289~299 (2016)
- Groeschel S, "Virchow-Robin spaces on magnetic resonance images : normative data, their dilatation, and a review of the literature", Neuroradiology, 48, pp.745~754 (2006)
- Ding J, "Large perivascular spaces visible on magnetic resonance imaging, cerebral small vessel disease progression, and risk of dementia : the age, gene", environment susceptibility–Reykjavik study, 2017, pp.74, 1105~1112
- Zhu YC, "Severity of dilated Virchow-Robin spaces is associated with age, blood pressure, and MRI markers of small vessel disease : a population-based study", Stroke, 41, pp.2483~2490 (2010)
- Banerjee G, "MRI-visible perivascular space location is associated with Alzheimer’s disease independently of amyloid burden", Brain, 140, pp.1107~1116 (2017)
- Charidimou A, "White matter perivascular spaces on magnetic resonance imaging : marker of cerebrovascular amyloid burden?", Stroke, 46, pp.1707~1709 (2015)
- Charidimou A, "White matter perivascular spaces : an MRI marker in pathology-proven cerebral amyloid angiopathy?", Neurology, 82, pp.57~62 (2014)
- Charidimou A, "White matter perivascular spaces are related to cortical superficial siderosis in cerebral amyloid angiopathy", Stroke, 45, pp.2930~2935 (2014)
- Martinez-Ramirez S, "Topography of dilated perivascular spaces in subjects from a memory clinic cohort", Neurology, 80, pp.1551~1556 (2013)
- Attems J, "Topographical distribution of cerebral amyloid angiopathy and its effect on cognitive decline are influenced by Alzheimer disease pathology", J Neurol Sci, 257, pp.49~55 (2007)
- Iliff JJ, "A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β", Sci Transl Med, 4, pp.147~ (2012)[DOI]
- Parlak MM, "Evaluation of Swallowing Function according to the Stage of Alzheimer’s Disease", Folia Phoniatr Logop, 74, pp.186~194 (2022)
- Munis ÖB, "Analysis of the consistency of information received from Alzheimer’s disease patients and their families in the quality of life and depression scales", Turkish Journal of Clinics and Laboratory, 12, pp.372~378 (2021)
- Parlak MM, "Dysphagia in Individuals with Dementia", Journal of Ear Nose Throat and Head Neck Surgery, pp.88~96 (2022)
- Parlak MM, "Investigation of cognition, nutrition, independence and swallowing difficulty, relationship with quality of life, and effect levels in elderly people with Alzheimer’s disease living with their families", Neurol Asia, 27, pp.701~708 (2022)
- Parlak MM, "The Effect of Holistic Therapy in Alzheimer’s Disease", Altern Ther Health Med, 29, pp.52~59 (2023)[DOI]
- Greenberg SM, "Cerebral amyloid angiopathy and Alzheimer disease-one peptide, two pathways", Nat Rev Neurol, 16, pp.30~42 (2020)
- de la Torre JC, "Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia", Cardiovasc Psychiatry Neurol, 2012, pp.367516~ (2012)
- Hansen TP, "Dilated perivascular spaces in the Basal Ganglia are a biomarker of small-vessel disease in a very elderly population with dementia", AJNR Am J Neuroradiol, 36, pp.893~898 (2015)
- Nguyen TT, "Type 3 diabetes and its role implications in Alzheimer’s disease", Int J Mol Sci, 21, pp.3165~ (2020)
- Charidimou A, "Sporadic cerebral amyloid angiopathy revisited : recent insights into pathophysiology and clinical spectrum", J Neurol Neurosurg Psychiatry, 83, pp.124~137 (2012)
- Patankar TF, "Dilatation of the Virchow-Robin space is a sensitive indicator of cerebral microvascular disease : study in elderly patients with dementia", AJNR Am J Neuroradiol, 26, pp.1512~1520 (2005)[DOI]
- Chen W, "Assessment of the Virchow-Robin Spaces in Alzheimer disease, mild cognitive impairment, and normal aging, using high-field MR imaging", AJNR Am J Neuroradiol, 32, pp.1490~1495 (2011)
- Zlokovic BV, "Cerebrovascular disease in Alzheimer’s disease", Trends Neurosci, 4, pp.202~208 (2005)
- Boespflug EL, "Targeted assessment of enlargement of the perivascular space in Alzheimer’s disease and vascular dementia subtypes implicates astroglial involvement specific to Alzheimer’s disease", J Alzheimers Dis, 66, pp.1587~1597 (2018)
- Huang P, "Factors associated with the dilation of perivascular space in healthy elderly subjects", Front Aging Neurosci, 13, pp.624732~ (2021)
- Brown R, "Understanding the role of the perivascular space in cerebral small vessel disease", Cardiovasc Res, 114, pp.1462~1473 (2018)
- Saeki N, "MR imaging of normal perivascular space expansion at midbrain", AJNR Am J Neuroradiol, 26, pp.566~571 (2005)[DOI]
- Kim YK, "The glymphatic system in diabetes-induced dementia", Front Neurol, 9, pp.867~ (2018)
- Jiang Q, "Impairment of the glymphatic system after diabetes", J Cereb Blood Flow Metab, 37, pp.1326~1337 (2017)
- Weller RO, "White matter changes in dementia : role of impaired drainage of interstitial fluid", Brain Pathol, 25, pp.63~78 (2015)
- Elster AD, "Focal high signal on MR scans of the midbrain caused by enlarged perivascular spaces : MR-pathologic correlation", AJNR Am J Neuroradiol, 11, pp.1119~1122 (1990)
- Doubal FN, "Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease", Stroke, 41, pp.450~454 (2010)
