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난소암 진단에서 Human Epididymis Protein 4의 유용성 및 한국인의 정상 참고범위

Human Epididymis Protein 4 as a Diagnostic Marker of Ovarian Cancer and Its Reference Interval in Korean Population

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참고문헌

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초록

HE4는 CA125와 함께 난소의 양성과 악성 종양을 감별하는 새로운 표지자이다. 난소 종괴가 있는 환자를 난소암 발생 고위험군과 저위험군으로 구분하기 위해 HE4, CA125와 폐경 유무를 조합한 risk of ovarian malignancy algorithm (ROMA)가 제안되었다. 한국인에서 설정한 HE4의 정상 참고범위는 제조사 권장 참고범위나 중국인을 대상으로 한 참고범위와 차이가 있었다.

Abstract

Human epididymis protein 4 (HE4), which complements cancer antigen 125 (CA125), has emerged as a new diagnostic biomarker that can discriminate between benign and malignant ovarian tumors. The risk of ovarian malignancy algorithm (ROMA) incorporates CA125, HE4, and menopausal status to classify patients with pelvic masses into those at high or low risk of developing ovarian cancer. The reference interval of HE4 among Korean population was different from those recommended by the manufacturer or evaluated in the Chinese.

참고문헌 (33)

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