제주지역 골반염 환자에서 PCR을 통해 본 감염양상
PCR-based Investigation of Infection Patterns in Patients with Pelvic Inflammatory Diseases in Jeju
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초록
배경: 골반염은 미생물 감염에 의한 자궁경부내구 상부의 생식기에 염증이 발생한 질환으로 자궁외 임신, 불임, 만성골반통증 등 심각한 합병증 때문에 진단과 치료가 매우 중요하다. 오래 전부터골반염의 주요 원인균은 클라미디아와 임균으로 알려져 왔으나 최근 원인균들의 변화가 보고되고 있어 제주지역에서 임상적으로 진단된 골반염 환자의 자궁경부검체에 대해 multiplex PCR검사를 통해 감염양상을 알아보고자 하였다. 방법: 임상적으로 골반염으로 진단하에 검사가 의뢰된 65 환자를대상으로 Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasmagenitalium, Mycoplasma hominis, Ureaplasma urealyticum,Trichomonas vaginalis 6종에 대해 multiplex PCR을 시행하였다. 결과: 균종별 양성환자는 C. trachomatis가 63%로 가장 많았고 M. hominis 34%, U. urealyticum 20%, N. gonorrhoeae 9%, T. vaginalis6% 순으로 나타났다. 결론: 골반염에서 C. trachomatis의 양성률이 여전히 가장 높은것으로 확인되었으며 M. hominis가 U. urealyticum에 비해 상대적으로 높은 양성률을 보였다.
Abstract
Background: Pelvic inflammatory disease (PID) is a microbial infection caused by the upward spread of infectious organisms through the cervical os. Early diagnosis and treatment of PID are essential for the prevention of sequelae such as ectopic pregnancies, infertility, and chronic pelvic pain. Although Chlamydia trachomatis and Neisseria gonorrhoeae are well-known causal agents of PID, there have been reports on some changes in PID-associated infection. The aim of this study was to investigate the infection patterns in patients with PID in Jeju. Methods: Endocervical samples obtained from 65 patients with PID were tested for C. trachomatis, Mycoplasma genitalium, Mycoplasma hominis,N. gonorrhoeae, Trichomonas vaginalis, and Ureaplasma urealyticum using multiplex PCR. Results: The samples were positive for C. trachomatis (63%), M. hominis (34%), U. urealyticum (20%), M. genitalium (17%), N. gonorrhoeae (9%), and T. vaginalis (6%). Conclusions: This study showed that C. trachomatis infection was prevalent and the incidence of M. hominis was higher than that of U. urealyticum.
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