순환종양핵산 검사의 임상 적용
Clinical Application of Circulating Tumor DNA Analysis
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참고문헌
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초록
순환종양핵산을 이용한 액체 생검은 기존 조직검사의 한계를 극복할 수 있다. 순환종양핵산을 이용한 비침습적 분자 프로파일링은 암의 진단 및 위험도 계층화, 표적 치료제 선택 등의 목적으 로 임상적 활용이 증가하고 있다. 순환종양핵산의 생물학적 특성과 순환종양핵산 농도에 영향을 미칠 수 있는 환자 요인을 이해하고 검사법을 최적화함으로써 순환종양핵산 검사의 임상적 활용 도를 높일 수 있을 것이다. 향후 순환종양핵산 검사의 수행 및 결과 보고에 대한 가이드라인의 마련에 대해서도 고려가 필요하다.
Abstract
Liquid biopsy using circulating tumor DNA helps overcome the limitations of conventional tissue testing. Non-invasive molecular profiling using circulating tumor DNA is increasingly being used to diagnose cancer, stratify risk, and select targeted treatments. By understanding the biological characteristics of circulating tumor DNA and patient factors that can affect concentrations of circulating tumor DNA as well as optimizing the techniques, the clinical utilization of circulating tumor DNA tests can be improved. It is also necessary to formulate guidelines for the administration and reporting of circulating tumor DNA tests.
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