A Randomized single blind controlled clinical trial on safety and efficacy of a Unani formulation (Itrifal-e-Sagheer) in dyslipidemia
0
조회
0
다운로드
1
인용
0
참고문헌
초록
Aim:‘Itrifal-e-Sagheer’, a compound Unani formulation has been indicated in disease conditions simulating dyslipidemia. The present study was done to substantiate the efficacy of ‘Itrifal-e-Sagheer’ in dyslipidemia on scientific parameters. Materials and methods: A randomized, single blind, controlled, clinical trial was carried out on 30 patients of dyslipidemia who were randomly allocated into test (n = 15) or control (n = 15) groups. The test drug, Itrifal-e-Sagheer and control drug, Abana® were given to respective group for 45 days along with lifestyle modification. Results: The test drug significantly alleviated the symptoms of subjective parameters (palpitation, breathlessness and weight gain) (p<0.05). There was statistically significant reduction in lipid profile of the patients in test group (p<0.05) than control drug treatment. Conclusion: The study evidenced that Itrifal-e-Sagheer is potentially effective and safe in the treatment of dyslipidemia. However, a multicentric study with robust study design is required to generalize the results.
Abstract
Aim:‘Itrifal-e-Sagheer’, a compound Unani formulation has been indicated in disease conditions simulating dyslipidemia. The present study was done to substantiate the efficacy of ‘Itrifal-e-Sagheer’ in dyslipidemia on scientific parameters. Materials and methods: A randomized, single blind, controlled, clinical trial was carried out on 30 patients of dyslipidemia who were randomly allocated into test (n = 15) or control (n = 15) groups. The test drug, Itrifal-e-Sagheer and control drug, Abana® were given to respective group for 45 days along with lifestyle modification. Results: The test drug significantly alleviated the symptoms of subjective parameters (palpitation, breathlessness and weight gain) (p<0.05). There was statistically significant reduction in lipid profile of the patients in test group (p<0.05) than control drug treatment. Conclusion: The study evidenced that Itrifal-e-Sagheer is potentially effective and safe in the treatment of dyslipidemia. However, a multicentric study with robust study design is required to generalize the results.
참고문헌 (23)
- Ahmad SI, "Al Umoor Al Tabi’yah", pp.162~167 (1980), CCRUM
- Ajay RS, "Prevalence of dyslipidaemia in South Indian adults : an urban rural comparison", Int J Community Med Public Health, 3(8), pp.2201~2210 (2016)
- Anonymous, "The Unani Pharmacopoeia of India. Part I, Volume I", pp.5~6 (2007), Ministry of AYUSH
- Bag A, "The development of Terminalia chebula Retz. (Combretaceae) in clinical research", Asian Pac J Trop Biomed, 3(3), pp.244~252 (2013)
- Baitar I, "Al Jami Li Mufradat Al Advia wa al Aghziya. Vol 1, 4", pp.129~131 (2000), Central Council for Research in Unani Medicine
- Baliga MS, "Triphala, ayurvedic formulation for treating and preventing cancer : a review", J Altern Complement Med, 16(12), pp.1301~1308 (2010)
- Bolli P, "Treatment of dyslipidaemia : The problem of reaching the goal", Atherosclerosis, 236, pp.142~143 (2014)
- Brunton LL, "Goodman and Gilman's the pharmacological basis of therapeutics", pp.984~995 (2001), McGraw Hill
- Ghani N., "Khazainul Advia", pp.187~189 (2008), Idara Kitab us Shifa
- Gilani HA, "Mechanisms underlying the antispasmodic and bronchodilatory properties of Terminalia bellerica fruit", J. of Ethnopharmacology, 116, pp.528~538 (2008)
- Kabeeruddin HM, "Biyaz Kabir. Vol 2", pp.5~, Hikmat Book Depo, YNM
- Kabiruddin A, "Kulliyate Qanun", pp.222~ (2006), Eajaz Publication
- Kamali SH, "Efficacy of ‘Itrifal Saghir’, a combination of three medicinal plants in the treatment of obesity; A randomized controlle d trial", DARU Journal of Pharmaceutical Sciences, 20(1), pp.1~8 (2012)
- Majoosi AIA, "Kamilus Sanaa. Vol. 1, 2", pp.52~53 (2010), Idara Kitab us Shifa
- Park K., "Park textbook of preventive and social medicine", pp.2017, M
- Rajak S, "Emblica officinalis causes myocardial adaptation and protects against oxidative stress in ischemic reperf usion injury in rats", Phytotherapy research, 18(1), pp.54~60 (2004)
- Shah SN, "API Text book of Medicine Vol 2", pp.1235~1239 (2012), The Association of physicians of India
- Singh RB, "Hypolipidemic and antioxidant effects of fenugreek seeds and triphala as adjuncts to dietary therapy in patients with mild to moderate hypercholesterolemia", Perfusion, 11(3), pp.124~ (1998)
- Suchalatha S, "Protective effect of Terminalia chebul a against experimental myocardial injury induced by isoproterenol", Indian J Exp Biol, 42(2), pp.174~178 (2004)
- Tariq M, "Protective effect of fruit extracts of Emblica officinalis (Gaertn). And Terminalia bellerica (Roxb .) in experimental myocardial necrosis in rats", Indian J Exp Biol, 15(6), pp.485~486 (1977)
- Tripathi KD, "Essentials of medical pharmacology", pp.634~644 (2013), Jaypee Brother Medical Publication
- Varady KA, "Combination diet and exer cise interventions for the treatment of dyslipidemia: an effective preliminary strategy to lower cholesterol levels?", J Nutr, 135(8), pp.1829~1835 (2005)
- Yang MH, "Constituents from Terminalia species increase PPAR alpha and PPAR gamma lev els and stimulate glucose uptake without enhancing adipocyte differentiation", J Ethnopharmacol, 149, pp.490~498 (2013)