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Merging the old with the new: a cybermedicine marriage for oncology interactions with traditional herbal therapies and complementary medicines

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An oncology-specific database called OncoRx (http://bit.ly/cancerRx) was previously set up in cyberspace to aid clinicians in identifying interactions of anticancer drugs (ACDs) and chemotherapy regimens with traditional Chinese medicines (TCMs) and complementary and alternative medicines (CAMs). Since then, users have requested the drug-CAM interactions (DCIs) of 5 specific CAMs (cranberry, melatonin, co-enzyme Q10, huachansu, reishi mushroom) to be updated in the database. Pharmacokinetic properties (metabolism, enzyme induction/inhibition, elimination), TCM properties and DCIs of each CAM were collated with 117 ACDs using 9 hardcopy compendia and online databases as resources. Additionally, individual ACDs and CAMs were used as keywords for PubMed searches in combination with the terms ‘anticancer drugs’, ‘drug interactions’, ‘herb-drug/drug-herb interactions’, ‘pharmacokinetic interactions’ and ‘pharmacodynamic interactions’. DCI parameters consisted of interaction effects, evidence summaries, proposed management plans and alternative non-interacting CAMs, together with relevant citations and update dates of the DCIs. OncoRx is also used as a case to introduce the “Four Pharmaco-cybernetic Maxims” of quality, quantity, relationship and manner to developers of digital healthcare tools. Its role in Hayne’s “5S” hierarchy of research evidence is also presented. OncoRx is meant to complement existing DCI resources for clinicians and alternative medicine practitioners as an additional drug information resource that provides evidence-based DCI information for ACD-CAM interactions.

Abstract

An oncology-specific database called OncoRx (http://bit.ly/cancerRx) was previously set up in cyberspace to aid clinicians in identifying interactions of anticancer drugs (ACDs) and chemotherapy regimens with traditional Chinese medicines (TCMs) and complementary and alternative medicines (CAMs). Since then, users have requested the drug-CAM interactions (DCIs) of 5 specific CAMs (cranberry, melatonin, co-enzyme Q10, huachansu, reishi mushroom) to be updated in the database. Pharmacokinetic properties (metabolism, enzyme induction/inhibition, elimination), TCM properties and DCIs of each CAM were collated with 117 ACDs using 9 hardcopy compendia and online databases as resources. Additionally, individual ACDs and CAMs were used as keywords for PubMed searches in combination with the terms ‘anticancer drugs’, ‘drug interactions’, ‘herb-drug/drug-herb interactions’, ‘pharmacokinetic interactions’ and ‘pharmacodynamic interactions’. DCI parameters consisted of interaction effects, evidence summaries, proposed management plans and alternative non-interacting CAMs, together with relevant citations and update dates of the DCIs. OncoRx is also used as a case to introduce the “Four Pharmaco-cybernetic Maxims” of quality, quantity, relationship and manner to developers of digital healthcare tools. Its role in Hayne’s “5S” hierarchy of research evidence is also presented. OncoRx is meant to complement existing DCI resources for clinicians and alternative medicine practitioners as an additional drug information resource that provides evidence-based DCI information for ACD-CAM interactions.

참고문헌 (134)

  1. Ahmadi K, "Effect of Ganoderma lucidum on cytokine release by peritoneal macrophages", Iran J Immunol, 4, pp.220~226 (2007)
  2. Baker L, "Use of the internet and e-mail for health care information : results from a national survey", JAMA, 289, pp.2400~2406 (2003)
  3. Belardinelli R, "Coenzyme Q10 and exercise training in chronic heart failure", Eur Heart J, 27, pp.2675~2681 (2006)
  4. Boles RG, "Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study", BMC Neurol, 10, pp.10~ (2010)
  5. Bristol-Myers Squibb Co., (2010)
  6. British Medical Association, "Pharmaceutical Society of Great Britain. British National Formulary" (2007), BMJ Publishing Group Ltd & RPS Publishing
  7. Brzezinski A., "Melatonin in humans", N Engl J Med, 336, pp.186~195 (1997)
  8. Cao LZ, "Comparison of the effects of polysaccharides from wood-cultured and bag-cultured Ganoderma lucidum on murine spleen lymphocyte proliferation in vitro", Yao Xue Xue Bao, 38, pp.92~97 (2003)
  9. Caroleo MC, "Melatonin as immunomodulator in immunodeficient mice", Immunopharmacology, 23, pp.81~89 (1992)
  10. Chan A, "Efficacy of antiemetics in patients receiving XELOX-A single-centre, prospective study", EJC supplements, 9, pp.17~ (2011)
  11. Chang L-C, "Patterns of complementary therapy use by homebound cancer patients in Taiwan", Appl Nurs Res, 17, pp.41~47 (2004)
  12. Chen HS, "Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum(Reishi)polysaccharides", Bioorg Med Chem, 12, pp.5595~5601 (2004)
  13. Chen NH, "Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2", 9 gene expression, 2008, pp.108, 212~216
  14. Chow WH, "Complementary and alternative medicine among Singapore cancer patients", Ann Acad Med Singapore, 39, pp.129~135 (2010)
  15. Clarke SJ, "When Cancer Crosses Disciplines: A Physician's Handbook", pp.285~316 (2010), Imperial College Press
  16. Combs AB, "Reduction by coenzyme Q10 of the acute toxicity of adriamycin in mice", Res Commun Chem Pathol Pharmacol, 18, pp.565~568 (1977)
  17. Conklin KA, "Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity", Integr Cancer Ther, 4, pp.110~130 (2005)
  18. DiGianni LM, "Complementary and alternative medicine use among women with breast cancer", J Clin Oncol, 20, pp.34s~38s (2002)
  19. "TCM Assistant"[URL]
  20. Ferguson PJ, "A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines", J Nutr, 134, pp.1529~1535 (2004)
  21. Ferguson PJ, "In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract", Nutr Cancer, 56, pp.86~94 (2006)
  22. Fua LN, "Oncology drug database greatly benefits elderly cancer patients", NUS Knowledge Enterprise, 11, pp.6~ (2011)
  23. Gao L, Wu X, "Comparison of traditional Chinese medicine with Western medicine cancer therapy", Chinese J Clin Oncol, 5, pp.231~234 (2008)
  24. Gao Y, "A randomized, placebo-controlled, multicenter study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) polysaccharides (Ganopoly) in patients with advanced lung cancer", Int J Med Mushrooms, 5, pp.49~62 (2003)
  25. Gao Y, "A phase I", II study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. extract (Ganopofy) in patients with advanced cancer, 2002, pp.4, 21~28
  26. Gao Y, "Effects of ganopoly(a Ganoderma lucidum polysaccharide extract)on the immune functions in advanced-stage cancer patients", Immunol Invest, 32, pp.201~215 (2003)
  27. "Memorial Sloan-Kettering Cancer Center -cancer information (about herbs, botanicals and other products)"[URL]
  28. Gonzalez A, "In vivo inhibition of the estrogen sulfatase enzyme and growth of DMBA-induced mammary tumors by melatonin", Curr Cancer Drug Targets, 10, pp.279~286 (2010)
  29. Grant P., "Warfarin and cranberry juice: an interaction?", J Heart Valve Dis, 13, pp.25~26 (2004)
  30. Greenberg S, "Co-enzyme Q10 : a new drug for cardiovascular disease", J Clin Pharmacol, 30, pp.596~608 (1990)
  31. Greenblatt DJ, "Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole : in vitro and clinical studies", Clin Pharmacol Ther, 79, pp.125~133 (2006)
  32. Griffiths AP, "Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin", J R Soc Promot Health, 128, pp.324~326 (2008)
  33. Thomson Healthcare, "Physicians' Desk Reference (PDR) for Herbal Medicines" (2007), Thomson Reuters
  34. Haldar C, "Melatonin blocks dexamethasone-induced immunosuppression in a seasonally breeding rodent Indian palm squirrel, Funambulus pennanti", Steroids, 69, pp.367~377 (2004)
  35. Hamann GL, "Warfarin-cranberry juice interaction", Ann Pharmacother, 45, pp.e17~ (2011)
  36. Han H-B, "The effect of cinobufacin combined with 5-FU on inhibiting proliferation and inducting apoptosis of human gastric carcinoma cells", Chinese J Gen Surgery, 9, pp.4~ (2006)
  37. Hashimoto S, "Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs", Leuk Res, 21, pp.875~883 (1997)
  38. Haynes RB, "Of studies, syntheses, synopses, summaries, and systems : the"5S"evolution of information services for evidence-based healthcare decisions", Evid Based Med, 11, pp.162~164 (2006)
  39. Hsiao WL, "The role of traditional Chinese herbal medicines in cancer therapy-from TCM theory to mechanistic insights", Planta Med, 76, pp.1118~1131 (2010)
  40. Hsu MJ, "Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase", Akt signaling pathway, 2002, pp.72, 207~216
  41. Huang KC, "The Pharmacology of Chinese Herbs" (1999), CRC Press
  42. Hyodo I, "Nationwide survey on complementary and alternative medicine in cancer patients in Japan", J Clin Oncol, 23, pp.2645~2654 (2005)
  43. Janssen Inc, (2011)
  44. Jellin JM, "Natural Medicines Comprehensive Database" (2007), Therapeutic Research Faculty
  45. Ji Z, "Immunomodulation of RAW264.7 macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum", J Ethnopharmacol, 112, pp.445~450 (2007)
  46. Jiang Y, "Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action", Cytotechnol, 62, pp.573~583 (2010)
  47. Kim KC, "Enhancement of radiation response with combined Ganoderma lucidum and Duchesnea chrysantha extracts in human leukemia HL-60 cells", Int J Mol Med, 21, pp.489~498 (2008)
  48. Kummervold PE, "EHealth trends in Europe 2005-2007: a population-based survey", J Med Internet Res, 10, pp.e42~ (2008)
  49. Lacy CF, "Drug Information Handbook with International Trade Names Index" (2008), Lexi-comp Inc
  50. Leja-Szpak A, "Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells(PANC-1)", J Pineal Res, 49, pp.248~255 (2010)
  51. Li HY, "Bufalin inhibits CYP3A4 activity in vitro and in vivo", Acta Pharmacol Sin, 30, pp.646~652 (2009)
  52. Li YB, "Serum amyloid A mediates the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells", Oncol Rep, 20, pp.549~556 (2008)
  53. Lilja JJ, "Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam-probes of CYP2C9, CYP1A2, and CYP3A4", Clin Pharmacol Ther, 81, pp.833~839 (2007)
  54. Lim MK, "Complementary and alternative medicine use in multiracial Singapore", Complement Ther Med, 13, pp.16~24 (2005)
  55. Lin KI, "Reishi polysaccharides induce immunoglobulin production through the TLR4", TLR2-mediated induction of transcription factor Blimp-1, 2006, pp.281, 24111~24123
  56. Lissoni P, "Is there a role for melatonin in supportive care?", Support Care Cancer, 10, pp.110~116 (2002)
  57. Lissoni P, "Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status", Eur J Cancer, 35, pp.1688~1692 (1999)
  58. Lissoni P, "A study of the mechanisms involved in the immunostimulatory action of the pineal hormone in cancer patients", Oncology, 50, pp.399~402 (1993)
  59. Lissoni P, "Treatment of cancer chemotherapy-induced toxicity with the pineal hormone melatonin", Support Care Cancer, 5, pp.126~129 (1997)
  60. Macek C., "East meets West to balance immunologic yin and yang", JAMA, 251, pp.433~435 (1984)
  61. Mansky PJ, "Complementary medicine in palliative care and cancer symptom management", Cancer J, 12, pp.425~431 (2006)
  62. Mao T, "Two mushrooms, Grifola frondosa and Ganoderma lucidum, can stimulate cytokine gene expression and proliferation in human T lymphocytes", Int J Immunother, 15, pp.13~22 (1999)
  63. Martin-Renedo J, "Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line", J Pineal Res, 45, pp.532~540 (2008)
  64. "Coenzyme Q10"[URL]
  65. Meng Z, "Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer", Cancer, 115, pp.5309~5318 (2009)
  66. Nahleh Z, "Complementary and alternative medicine in breast cancer patients", Palliat Support Care, 1, pp.267~273 (2003)
  67. "Medline Plus Herbs and Supplements"[URL]
  68. "National Center for Complementary and Alternative Medicine"[URL]
  69. Neto CC, "Anticancer activities of cranberry phytochemicals: an update", Mol Nutr Food Res, 52, pp.S18~S27 (2008)
  70. Ngo N, "Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans", Drug Metab Dispos, 37, pp.514~522 (2009)
  71. Oldendick R, "South Carolina Complementary Medicine Program Baseline Research Team", South Med J, 93, pp.375~381 (2000)
  72. Ortiz-Lopez L, "ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration", J Pineal Res, 46, pp.15~21 (2009)
  73. OSI Pharmaceuticals Inc., (2008)
  74. Paeng CH, "Interaction between warfarin and cranberry juice", Clin Ther, 29, pp.1730~1735 (2007)
  75. Park JW, "Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells", J Pineal Res, 46, pp.415~421 (2009)
  76. "Cancer drug database may protect patients" (2011)[URL]
  77. Poon S, "Analysis of synergistic and antagonistic effects of TCM: Cases on diabetes and insomnia", Paper presented at: IEEE International Conference on Bioinformatics and Biomedicine Workshops (2010)
  78. Qi F, "Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor", Int Immunopharmacol, 11, pp.342~349 (2011)
  79. Qin TJ, "Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma", World J Gastroenterol, 14, pp.5210~5216 (2008)
  80. "TCM Materia Medica (Chinese Herbal Database)"[URL]
  81. "Rootdown.us - grow together (v2.187.423.57)"[URL]
  82. Rosenfeldt FL, "Coenzyme Q10 in the treatment of hypertension : a meta-analysis of the clinical trials", J Hum Hypertens, 21, pp.297~306 (2007)
  83. Roxane Laboratories Inc, (2007)
  84. Sagar SM, "Chinese medicine and biomodulation in cancer patients-Part one", Curr Oncol, 15, pp.42~48 (2008)
  85. Seeram NP, "Total cranberry extract versus its phytochemical constituents : antiproliferative and synergistic effects against human tumor cell lines", J Agric Food Chem, 52, pp.2512~2517 (2004)
  86. Shim M, "Connecting internet use with gaps in cancer knowledge", Health Commun, 23, pp.448~461 (2008)
  87. Shinozawa S, "Tissue concentration of doxorubicin(adriamycin)in mouse pretreated with alpha-tocopherol or coenzyme Q10", Acta Med Okayama, 45, pp.195~199 (1991)
  88. Shinozawa S, "Effect of biological membrane stabilizing drugs(coenzyme Q10, dextran sulfate and reduced glutathione)on adriamycin(doxorubicin)-induced toxicity and microsomal lipid peroxidation in mice", Gan To Kagaku Ryoho, 23, pp.93~98 (1996)
  89. Sparreboom A, "Herbal remedies in the United States : potential adverse interactions with anticancer agents", J Clin Oncol, 22, pp.2489~2503 (2004)
  90. Stothers L, "A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women", Can J Urol, 9, pp.1558~1562 (2002)
  91. Sun J, "Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells", Cancer Lett, 241, pp.124~134 (2006)
  92. Suvarna R, "Possible interaction between warfarin and cranberry juice", BMJ, 327, pp.1454~ (2003)
  93. Takai N, "Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells", Int J Mol Med, 21, pp.637~643 (2008)
  94. Tan KY, "The role of traditional Chinese medicine in colorectal cancer treatment", Tech Coloproctol, 12, pp.1~6 (2008)
  95. Tasaki K, "Communication between physicians and cancer patients about complementary and alternative medicine : exploring patients' perspectives", Psychooncol, 11, pp.212~220 (2002)
  96. Tascilar M, "Complementary and alternative medicine during cancer treatment : beyond innocence", Oncologist, 11, pp.732~741 (2006)
  97. [URL]
  98. Trubiani O, "Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic pathway activation", J Pineal Res, 39, pp.425~431 (2005)
  99. "China National Knowledge Infrastructure (CNKI)"[URL]
  100. Tsubaki K, "Investigation of the preventive effect of CoQ10 against the side-effects of anthracycline antineoplastic agents", Gan To Kagaku Ryoho, 11, pp.1420~1427 (1984)
  101. Uesawa Y, "Effects of cranberry juice on nifedipine pharmacokinetics in rats", J Pharm Pharmacol, 58, pp.1067~1072 (2006)
  102. Ulbricht C, "Reishi mushroom(Ganoderma lucidum) : Systematic review by the natural standard research collaboration", J Soc Integr Oncol, 8, pp.148~159 (2010)
  103. Ushijima K, "The inhibitory effect of cranberry juice on phenytoin metabolism by human liver microsomes", Jap J Clin Pharmacol Ther, 40, pp.59~64 (2009)
  104. Ushijima K, "Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects", Br J Clin Pharmacol, 68, pp.194~200 (2009)
  105. Wachtel-Galor S, "Ganoderma lucidum('Lingzhi'); acute and short-term biomarker response to supplementation", Int J Food Sci Nutr, 55, pp.75~83 (2004)
  106. Wachtel-Galor S, "Ganoderma lucidum("Lingzhi"), a Chinese medicinal mushroom : biomarker responses in a controlled human supplementation study", Br J Nutr, 91, pp.263~269 (2004)
  107. Wang CZ, "Effects of ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model", Am J Chin Med, 33, pp.807~815 (2005)
  108. Wang SY, "The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes", Int J Cancer, 70, pp.699~705 (1997)
  109. Wang X, "Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats", Biol Pharm Bull, 30, pp.1702~1706 (2007)
  110. Welch JM, "Probable elevation in international normalized ratio from cranberry juice", J Pharm Technol, 23, pp.104~107 (2007)
  111. Weng CJ, "The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis", Clin Exp Metastasis, 27, pp.361~369 (2010)
  112. White JD, "The National Cancer Institute's perspective and agenda for promoting awareness and research on alternative therapies for cancer", J Altern Complement Med, 8, pp.545~550 (2002)
  113. Wong R, "Integration of Chinese medicine into supportive cancer care : a modern role for an ancient tradition", Cancer Treat Rev, 27, pp.235~246 (2001)
  114. Wu W-Y, "Synergistic anti-cancer effects and mechanisms of huachansu plus vinorelbine on Lewis lung cancer cell in mice", China Oncol, 4, pp.18~ (2004)
  115. Xu X-Q, "Study on the effects of Cinobufacin combined with taxol on murine S180 tumor in vivo", Strait Pharmaceutical J, 2, pp.8~ (2009)
  116. Yang P, "Anti-proliferative activity of Huachansu, a Bufo toad skin extract, against human malignant melanoma cells", Paper presented (2006), American Association for Cancer Research
  117. Yang P, "Huachansu inhibits growth of human pancreatic cancer Panc-1 and BxPC3 xenograft tumors", Paper presented at: 99th American Association for Cancer Research (AACR) Annual Meeting (2008)
  118. Yap KY-L, "Improving pharmaceutical care in oncology by pharmacoinformatics : the evolving role of informatics and the internet for drug therapy", Lancet Oncol, 10, pp.1011~1019 (2009)
  119. Yap KY-L, "Opinions on drug interaction sources in anticancer treatments and parameters for an oncology-specific database by pharmacy practitioners in Asia", Health Services Insights, 3, pp.1~12 (2010)
  120. Yap KY-L, "Oncoinformatics for the healthcare professional : oncology databases and blogs", Internet J Oncol, 6, pp.1~22 (2009)
  121. Yap KY-L, "Pharmaco-cybernetics as an interactive component of pharma-culture : empowering drug knowledge through user-, experience-and activity-centered designs", Int J Comput Sci Issues, 3, pp.1~13 (2009)
  122. Yap KY-L, "Clinically-relevant chemotherapy interactions with complementary and alternative medicines in patients with cancer", Recent Pat Food Nutr Agric, 2, pp.12~55 (2010)
  123. Yap KY, "Drug interactions between chemotherapeutic regimens and antiepileptics", Clin Ther, 30, pp.1385~1407 (2008)
  124. Yap KY, "An onco-informatics database for anticancer drug interactions with complementary and alternative medicines used in cancer treatment and supportive care : an overview of the OncoRx project", Support Care Cancer, 18, pp.883~891 (2010)
  125. Yates JS, "Prevalence of complementary and alternative medicine use in cancer patients during treatment", Support Care Cancer, 13, pp.806~811 (2005)
  126. Yu CH, "Apoptotic signaling in bufalin-and cinobufagin-treated androgen-dependent and-independent human prostate cancer cells", Cancer Sci, 99, pp.2467~2476 (2008)
  127. Yun HR, "Apoptosis induction of human lung carcinoma cells by Chan Su(Venenum Bufonis)through activation of caspases", J Acupunct Meridian Stud, 2, pp.210~217 (2009)
  128. Zhang L, "Apoptosis of monocytic leukemia cells induced by etoposide with the cooperation of cinobufacini", Journal of Internal Medicine Concepts and Practice, 2, pp.12~ (2007)
  129. Zhang L, "Efficacy of cranberry juice on Helicobacter pylori infection : a double-blind, randomized placebo-controlled trial", Helicobacter, 10, pp.139~145 (2005)
  130. Zhao S, "Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin", Int J Oncol, 38, pp.1319~1327 (2011)
  131. Zhou J, "New understanding of the basic theory of traditional Chinese medicine", Chin J Integr Med, 15, pp.7~12 (2009)
  132. Ziebland S, "How the internet affects patients' experience of cancer : a qualitative study", BMJ, 328, pp.564~569 (2004)
  133. Zikria J, "Cranberry juice and warfarin : when bad publicity trumps science", Am J Med, 123, pp.384~392 (2010)
  134. Zupancic D, "Melatonin prevents the development of hyperplastic urothelium induced by repeated doses of cyclophosphamide", Virchows Arch, 454, pp.657~666 (2009)

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