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Anti-inflammatory effects of porcine placenta in forced swimming tested fatigue mice and RAW264.7 cells

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초록

Inflammation has been linked to various diseases. Especially, fatigue is a frequent symptom in several inflammatory disorders. Therefore, blocking inflammatory process is effective in fatigue. We investigated whether Denmark porcine placenta (DPP) alleviates fatigue by inhibiting inflammatory reaction using forced swimming test (FST) animal model and RAW264.7 cells. In FST-induced fatigue animal model, the mice which received the DPP for 21 days showed decreases of interleukin (IL)-1β and IL-6 serum levels. Furthermore, our data revealed that lipopolysaccharide (LPS)-induced IL-1β, IL-6, and tumor necrosis factor-α secretion were markedly inhibited by DPP in RAW264.7 cells without inducing cytotoxicity. LPS-enhanced nitric oxide secretion and inducible nitric oxide synthase expression were inhibited by DPP. The present study also figured out that these effects of DPP were mediated by blockade of caspase-1 and nuclear factor-B activation. Taken together, our results indicated that DPP could be alleviating fatigue as candidate of anti-inflammatory agent.

Abstract

Inflammation has been linked to various diseases. Especially, fatigue is a frequent symptom in several inflammatory disorders. Therefore, blocking inflammatory process is effective in fatigue. We investigated whether Denmark porcine placenta (DPP) alleviates fatigue by inhibiting inflammatory reaction using forced swimming test (FST) animal model and RAW264.7 cells. In FST-induced fatigue animal model, the mice which received the DPP for 21 days showed decreases of interleukin (IL)-1β and IL-6 serum levels. Furthermore, our data revealed that lipopolysaccharide (LPS)-induced IL-1β, IL-6, and tumor necrosis factor-α secretion were markedly inhibited by DPP in RAW264.7 cells without inducing cytotoxicity. LPS-enhanced nitric oxide secretion and inducible nitric oxide synthase expression were inhibited by DPP. The present study also figured out that these effects of DPP were mediated by blockade of caspase-1 and nuclear factor-B activation. Taken together, our results indicated that DPP could be alleviating fatigue as candidate of anti-inflammatory agent.

참고문헌 (43)

  1. Bluthé RM, "Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behavior : a study with interleukin-1 type I receptor-deficient mice", Eur J Neurosci, 12, pp.4447~4456 (2000)
  2. Bluthé RM, "Lipopolysaccharide induces sickness behavior in rats by a vagal mediated mechanism", C R Acad Sci, 317, pp.499~503 (1994)
  3. Bower JE, "Cytokine genetic variations and fatigue among patients with breast cancer", J Clin Oncol, 31, pp.1656~1661 (2013)
  4. Buchwald D, "Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome", J Rheumatol, 24, pp.371~376 (1997)
  5. Dantzer R, "From inflammation to sickness and depression : when the immune system subjugates the brain", Nat Rev Neurosci, 9, pp.46~56 (2008)
  6. Giovannoni G, "Daily urinary neopterin excretion as an immunological marker of disease activity in multiple sclerosis", Brain, 120, pp.1~13 (1997)
  7. Hahn G, "Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy", J Clin Invest, 91, pp.862~870 (1993)
  8. Han NR, "Glutamic acid ameliorates estrogen deficiency-induced menopausal-like symptoms in ovariectomized mice", Nutr Res, 35, pp.774~783 (2015)
  9. Han NR, "Porcine placenta mitigates protein-energy malnutrition-induced fatigue", Nutrition, 29, pp.1381~1387 (2013)
  10. Harboe E, "Fatigue in primary Sjögren’s syndrome–a link to sickness behaviour in animals", Brain Behav Immun, 23, pp.1104~1108 (2009)
  11. 홍기배, "Effects of Porcine Placenta Extract Ingestion on Ultraviolet B-induced Skin Damage in Hairless Mice", 한국축산식품학회지, 35(3), pp.413~420 (2015), 한국축산식품학회
  12. Ifuku M, "Induction of interleukin-1beta by activated microglia is a prerequisite for immunologically induced fatigue", Eur J Neurosci, 40, pp.3253~3263 (2014)
  13. Jeong HJ, "Gomisin A decreases the LPS-induced expression of iNOS and COX-2 and activation of RIP2", NF-κB in mouse peritoneal macrophages, 2014, pp.36, 195~201
  14. Jeong HJ, "Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells", Cytokine, 18, pp.252~259 (2002)
  15. Kang SS, "Human placenta promotes IL-8 expression through activation of JNK", SAPK and transcription factors NFkappaB and AP-1 in PMA-differentiated THP-1 cells, 2007, pp.7, 1488~1495
  16. Kelly KW, "Cytokine-induced sickness behavior", Brain Behav Immun, 17, pp.S112~S118 (2003)
  17. Kerr JR, "Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue", J Gen Virol, 82, pp.2011~2019 (2001)
  18. Kim MH, "Estrogen-like osteoprotective effects of glycine in vitro and in vivo models of menopause", Amino Acids, 48, pp.791~800 (2016)
  19. Lenardo MJ, "NF-kappa B : A pleiotropic mediator of inducible and tissue-specific gene control", Cell, 58, pp.227~229 (1989)
  20. Li P, "Mice deficient in IL-1 betaconverting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock", Cell, 80, pp.401~411 (1995)
  21. Libermann TA, "Activation of interleukin-6 gene expression through the NF-kappa B transcription factor", Mol Cell Biol, 10, pp.2327~2334 (1990)
  22. Nacul LC, "Prevalence of myalgic encephalomyelitis", chronic fatigue syndrome(ME, BMC Med, pp.2011, 9[DOI]
  23. Nam SY, "Efficacy of proline in the treatment of menopause", Exp Biol Med, 241, pp.611~619 (2016)
  24. Nijs J, "Oxidative stress might reduce essential fatty acids in erythrocyte membranes of chronic fatigue syndrome patients", Nutr Neurosci, 7, pp.251~253 (2004)
  25. Norheim KB, "Biological mechanisms of chronic fatigue", Rheumatology, 50, pp.1009~1018 (2011)
  26. Norheim KB, "Oxidative stress, as measured by protein oxidation, is increased in primary Sjögren’s syndrome", Free Radic Res, 46, pp.141~146 (2012)
  27. Omdal R, "The effect of interleukin-1 blockade on fatigue in rheumatoid arthritis-a pilot study", Rheumatol Int, 25, pp.481~484 (2005)
  28. Ouellet MC, "Fatigue following traumatic brain injury : frequency, characteristics, and associated factors", Rehabil Psychol, 51, pp.140~149 (2006)
  29. Pal P, "A human placenta extract : in vivo and in vitro assessments of its melanocyte growth and pigmentinducing activities", Int J Dermatol, 41, pp.760~767 (2002)
  30. Pall ML, "Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome", Med Hypotheses, 54, pp.115~125 (2000)
  31. Prins JB, "Chronic fatigue syndrome", Lancet, 367, pp.346~355 (2006)
  32. Schubert C, "The association between fatigue and inflammatory marker levels in cancer patients : a quantitative review", Brain Behav Immun, 21, pp.413~427 (2007)
  33. Skouroliakou M, "A double-blind, randomized clinical trial of the effect of omega-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition", Eur J Clin Nutr, 64, pp.940~947 (2010)
  34. Smedley H, "Neurological effects of recombinant human interferon", Br Med J, 286, pp.262~264 (1983)
  35. Stulemeijer M, "Recovery from mild traumatic brain injury : a focus on fatigue", J Neurol, 253, pp.1041~1047 (2006)
  36. Stutz A, "Inflammasomes : too big to miss", J Clin Invest, 119, pp.3502~3511 (2009)
  37. Swiergiel AH, "The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice : effects of acute and chronic administration of the interleukin-1-receptor antagonist(IL-1ra)", Brain Res, 776, pp.96~104 (1997)
  38. Tiesset H, "Dietary(n-3)polyunsaturated fatty acids affect the kinetics of pro-and antiinflammatory responses in mice with Pseudomonas aeruginosa lung infection", J Nutr, 139, pp.82~89 (2009)
  39. Togashi S, "Antioxidative collagen-derived peptides in humanplacenta extract", Placenta, 23, pp.497~502 (2002)
  40. Tonello G, "Characterization and quantitation of the active polynucleotide fraction(PDRN)from human placenta, a tissue repair stimulating agent", J Pharm Biomed Anal, 14, pp.1555~1560 (1996)
  41. Xie QW, "Role of transcription factor NF-kappa B", Rel in induction of nitric oxide synthase, 1994, pp.269, 4705~4708
  42. Yeom MJ, "Therapeutic effects of Hominis placenta injection into an acupuncture point on the inflammatory responses in subchondral bone region of adjuvant-induced polyarthritic rat", Biol Pharm Bull, 26, pp.1472~1477 (2003)
  43. Zhang ZT, "Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome", J Neuroinflammation, 13, pp.71~ (2016)

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