성인 조현병 환자의 심혈관질환 동반에 따른 입원 위험 및 질병 비용: 후향적 단면연구
Association Between Comorbid Cardiovascular Disease and the Risk of Hospitalization and Economic Burden in Adult Schizophrenia Patients: A Retrospective Cross-Sectional Study
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Objectives: This study was conducted to analyze the association between comorbid cardiovascular disease (CVD) and the risk of hospitalization and economic burden in adult schizophrenic patients. Methods: We used pooled claims data of 2017 and 2018 Health Insurance Review and Assessment- Patient sample. The total number of adult patients with schizophrenia (International Classification Disease code, 10th version [ICD-10 codes]: F2x) was identified as 20,655, of which 7,221 patients had CVD (ICD 10-codes: Ixx) and 12,549 patients did not. To evaluate the association between comorbidity of CVD and the risk of hospitalization, total medical expenditure, and total inpatient costs from the perspective of National Health Insurance, we used logistic regression, generalized linear model, Tweedie model regression, respectively. Results: According to regression analysis, schizophrenia patients with CVD had a 1.329 times higher risk of experiencing hospitalization (odds ratio: 1.329, 95% confidence interval [CI]: 1.232–1.434) than those without CVD. Also, schizophrenia patients with CVD had 1.264 times (cost ratio=1.264, 95% CI: 1.219–1.311) greater total medical costs than those without CVD. Finally, we observed that schizophrenia patients with CVD had 1.036 times (cost ratio=1.036, 95% CI: 0.978–1.097) higher inpatient costs than those without CVD patients, but it was not statistically significant. Conclusion: CVD seems to be significantly associated with increased risk of hospitalization and health care costs in patients with schizophrenia. Therefore, we should emphasize the importance for managing CVD for schizophrenic patients.
Abstract
Objectives: This study was conducted to analyze the association between comorbid cardiovascular disease (CVD) and the risk of hospitalization and economic burden in adult schizophrenic patients. Methods: We used pooled claims data of 2017 and 2018 Health Insurance Review and Assessment- Patient sample. The total number of adult patients with schizophrenia (International Classification Disease code, 10th version [ICD-10 codes]: F2x) was identified as 20,655, of which 7,221 patients had CVD (ICD 10-codes: Ixx) and 12,549 patients did not. To evaluate the association between comorbidity of CVD and the risk of hospitalization, total medical expenditure, and total inpatient costs from the perspective of National Health Insurance, we used logistic regression, generalized linear model, Tweedie model regression, respectively. Results: According to regression analysis, schizophrenia patients with CVD had a 1.329 times higher risk of experiencing hospitalization (odds ratio: 1.329, 95% confidence interval [CI]: 1.232–1.434) than those without CVD. Also, schizophrenia patients with CVD had 1.264 times (cost ratio=1.264, 95% CI: 1.219–1.311) greater total medical costs than those without CVD. Finally, we observed that schizophrenia patients with CVD had 1.036 times (cost ratio=1.036, 95% CI: 0.978–1.097) higher inpatient costs than those without CVD patients, but it was not statistically significant. Conclusion: CVD seems to be significantly associated with increased risk of hospitalization and health care costs in patients with schizophrenia. Therefore, we should emphasize the importance for managing CVD for schizophrenic patients.
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