소아암 환아에서 Cisplatin 투여시 병용되는 Sodium thiosulfate (Ametox®)의 신독성 예방 효과 평가
Evaluation of the efficacy of Sodium thiosulfate(Ametox®) for prevention of Cisplatin induced nephrotoxicity in pediatric patients
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Cisplatin(CDDP) is an important chemotherapeutic agent used in variety cancers, however its nephrotoxicity is a dose limiting toxicity in chemotherapy. Sodium thiosulfate(STS) is one of the most widely used antidotes against CDDP, which has been using for prevention of CDDP induced nephrotoxicity in adults. In Pediatric Hemato-Oncology of Seoul National University Children Hospital, STS has been using for prevention of nephrotoxicity of CDDP since 2002. There are no evidences that STS prevents CDDP induced nephrotoxicity in pediatric patients. So we evaluated the efficacy of STS for prevention of CDDP induced nephrotoxicity. From 1997 to 2006, we retrospectively reviewed 39 pediatric patients who diagnosed neuroblastoma and treated by CCG321P2 regimen by using the Electonic Medical Record(EMR). 19 pediatric patients received only chemotherapy [STS(-) group] and 20 pediatric patients received STS with combination chemotherapy which contains CDDP [STS(+) group] before and after 2002. Blood urea nitrogen(BUN) and serum creatinine were measured to evaluate glomerular function. Na, K and Mg level in serum were measured and urine protein test was done to evaluate proximal tubular function. There were no significant differences in basal patients characteristics between the STS(+) and STS(-) group. But the STS(-) group revealed more increasing serum creatinine level with repeating chemotherapy cycles and more increasing incidences of hypomagnesemia and proteinuria than STS(+) group. Therefore we concluded that STS in combination chemotherapy with CDDP have a positive effect on preventing cisplatin-induced nephrotoxicity in pediatric patients.
Abstract
Cisplatin(CDDP) is an important chemotherapeutic agent used in variety cancers, however its nephrotoxicity is a dose limiting toxicity in chemotherapy. Sodium thiosulfate(STS) is one of the most widely used antidotes against CDDP, which has been using for prevention of CDDP induced nephrotoxicity in adults. In Pediatric Hemato-Oncology of Seoul National University Children Hospital, STS has been using for prevention of nephrotoxicity of CDDP since 2002. There are no evidences that STS prevents CDDP induced nephrotoxicity in pediatric patients. So we evaluated the efficacy of STS for prevention of CDDP induced nephrotoxicity. From 1997 to 2006, we retrospectively reviewed 39 pediatric patients who diagnosed neuroblastoma and treated by CCG321P2 regimen by using the Electonic Medical Record(EMR). 19 pediatric patients received only chemotherapy [STS(-) group] and 20 pediatric patients received STS with combination chemotherapy which contains CDDP [STS(+) group] before and after 2002. Blood urea nitrogen(BUN) and serum creatinine were measured to evaluate glomerular function. Na, K and Mg level in serum were measured and urine protein test was done to evaluate proximal tubular function. There were no significant differences in basal patients characteristics between the STS(+) and STS(-) group. But the STS(-) group revealed more increasing serum creatinine level with repeating chemotherapy cycles and more increasing incidences of hypomagnesemia and proteinuria than STS(+) group. Therefore we concluded that STS in combination chemotherapy with CDDP have a positive effect on preventing cisplatin-induced nephrotoxicity in pediatric patients.
참고문헌 (20)
- Pfeifle C.E, "High-dose cisplatin with sodium thiosulfate protection", Journal of Clinical Oncology, 3, pp.237~244 (1985)
- Hirosawa A, "Effects of sodium thio-sulfate in combination therapy of cisdichlorodiammineplatinum and vindesine", Cancer Chemotherapy Pharmacology, 23, pp.255~258 (1989)
- Daugaard G., "Cisplatin nephrotoxicity", Cancer Chemother Pharmacol, 25, pp.1~9 (1989)
- Gandara D.R, "Cisplatin rescue therapy: experience with sodium thiosulfate, WR2721 and diethyldithiocarbamate", Crit Rev On col Hematol, 10(4), pp.353~365 (1990)
- Levi J., "Mechanism of cisplatin nephrotoxicity: 1. Effects of sullhydrl groups in rat kidneys", J Pharmncol Exp Ther, pp.213~545 (1980)
- Jones M.M., "Relative effectiveness of some compounds for the control of cisplatininduced nephrotoxicity", Toxicology, 68, pp.227~224 (1991)
- Wagner T, "Effects of fosfomycin, mesna, and sodium thiosulfate on the toxicity and antitumor activity of cispIa tin", J Cancer Res Clin Oncol, 114, pp.497~501 (1988)
- Montine T.J., "Quiescent LLC-PK1 cells as a model for cisdiamminedichloroplatinum(II) nephrotoxicity and modulation by thiol rescue agents", Cancer Research, 48(1), pp.6017~6024 (1988)
- Chen KK, "Nitrite and thiosulfate therapy in cyanide poisoning", JAMA, 149(113) (1952)
- Howell S.B, "Intraperitoneal cis diamminedichloroplatinum with systemic thiosulfate protection", Cancer Research, 43, pp.1426~1431 (1983)
- Guastalla J.P., "Phase II trial for intraperitoneal cisplatin plus intravenous sodium thiosulphate in advanced ovarian carcinoma patients with minimal residual disease after cisplatin-based chemotherapy a phase II study of the EORTC gynaecological cancer cooperative group", European Journal of Cancer, 30A(1), pp.45~49 (1994)
- Bonetti A, "High -dose biweekly intraperitoneal cisplatin : An effective way to increase cisplatin dose intensity", Gynecologic oncology, 49, pp.318~324 (1993)
- Maurie M, "Phase-l trial of high-dose intravenous cisplatin with simultaneous intravenous sodium thiosulfate", J Cancer Res Clin On col, 117, pp.151~155 (1991)
- Erdlenbruch B, "Accidental cisplatin overdose in a child: Reversal of acute renal failure with sodium thiosulfate", Med Pediatr Oncol, 38, pp.34973~ (2002)
- Fiser RT, "Outcome of severe sepsis in pediatric oncology patients", Pediatr Crit Care Med, 6, pp.531~536 (2005)
- 안효섭, "홍창의 소아과학" (2007), 대한교과서
- Lexi-Comp, Inc, "Pediatric dosage hand-book", American Pharmaceutical Association
- Daugaard G, "Renal tubular functions in patients treated with high-dose cisplatin", Clin Pharmacol Ther, 44(2), pp.164~172 (1988)
- Lammers P.J, "Cis-platinum induced renal sodium wasting", Med Pediatr Oncol, 12, pp.343~346 (1984)
- Markman M, "Hypomagnesemia following high dose intracavitary cisplatin with systemically administered sodium thiosulfate", Am J Clin On col, 9, pp.440~ (1986)