mTOR-coordinated Post-Transcriptional Gene Regulations: from Fundamental to Pathogenic Insights

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참고문헌 (67)

1. El Marabti E, "The cancer spliceome : reprograming of alternative splicing in cancer", Front Mol Biosci, 5, pp.80~ (2018)
2. David CJ, "Alternative pre-mRNA splicing regulation in cancer : pathways and programs unhinged", Genes Dev, 24, pp.2343~2364 (2010)
3. Tian B, "Alternative cleavage and polyadenylation : the long and short of it", Trends Biochem Sci, 38, pp.312~320 (2013)
4. Di Giammartino DC, "Mechanisms and consequences of alternative polyadenylation", Mol Cell, 43, pp.853~866 (2011)
5. Laplante M, "mTOR signaling at a glance", J Cell Sci, 122, pp.3589~3594 (2009)
6. Laplante M, "mTOR signaling in growth control and disease", Cell, 149, pp.274~293 (2012)
7. Ma XM, "Molecular mechanisms of mTOR-mediated translational control", Nat Rev Mol Cell Biol, 10, pp.307~318 (2009)
8. Laplante M, "Regulation of mTORC1 and its impact on gene expression at a glance", J Cell Sci, 126, pp.1713~1719 (2013)
9. Hsieh AC, "The translational landscape of mTOR signalling steers cancer initiation and metastasis", Nature, 485, pp.55~61 (2012)
10. Herzel L, "Splicing and transcription touch base : co-transcriptional spliceosome assembly and function", Nat Rev Mol Cell Biol, 18, pp.637~650 (2017)
11. Hicks MJ, "Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns", PLoS Biol, 4, pp.e147~ (2006)
12. David CJ, "The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex", Genes Dev, 25, pp.972~983 (2011)
13. Pan Q, "Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing", Nat Genet, 40, pp.1413~1415 (2008)
14. Huelga SC, "Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins", Cell Reports, 1, pp.167~178 (2012)
15. Zhou Z, "Regulation of splicing by SR proteins and SR protein-specific kinases", Chromosoma, 122, pp.191~207 (2013)
16. Shen S, "rMATS : robust and flexible detection of differential alternative splicing from replicate RNA-Seq data", Proc Natl Acad Sci U S A, 111, pp.E5593~E5601 (2014)
17. Wang Y, "Mechanism of alternative splicing and its regulation", Biomed Rep, 3, pp.152~158 (2015)
18. Rosenstiel P, "Functional characterization of two novel 5′ untranslated exons reveals a complex regulation of NOD2 protein expression", BMC Genomics, 8, pp.472~ (2007)
19. Wang G, "Differences in the translation efficiency and mRNA stability mediated by 5′-UTR splice variants of human SP-A1 and SP-A2 genes", Am J Physiol Lung Cell Mol Physiol, 289, pp.L497~L508 (2005)
20. Jeongsik Yong, "Alternative Polyadenylation of mRNAs: 3’-Untranslated Region Matters in Gene Expression", Molecules and Cells, 39(4), pp.281~285 (2016), 한국분자세포생물학회
21. Zhang X, "To polyadenylate or to deadenylate : that is the question", Cell Cycle, 9, pp.4437~4449 (2010)
22. Proudfoot NJ, "Ending the message : poly(A)signals then and now", Genes Dev, 25, pp.1770~1782 (2011)
23. Kornblihtt AR, "Shortcuts to the end", Nat Struct Mol Biol, 11, pp.1156~1157 (2004)
24. West S, "Human 5′ → 3′ exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites", Nature, 432, pp.522~525 (2004)
25. Kim M, "The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II", Nature, 432, pp.517~522 (2004)
26. Elkon R, "Alternative cleavage and polyadenylation : extent, regulation and function", Nat Rev Genet, 14, pp.496~506 (2013)
27. Martin G, "Genome-wide analysis of pre-mRNA 3′ end processing reveals a decisive role of human cleavage factor I in the regulation of 3′ UTR length", Cell Reports, 1, pp.753~763 (2012)
28. Masamha CP, "CFIm25 links alternative polyadenylation to glioblastoma tumour suppression", Nature, 510, pp.412~416 (2014)
29. Yang Q, "Structural basis of UGUA recognition by the Nudix protein CFIm25 and implications for a regulatory role in mRNA 3′ processing", Proc Natl Acad Sci U S A, 107, pp.10062~10067 (2010)
30. Takagaki Y, "The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation", Cell, 87, pp.941~952 (1996)
31. Bava FA, "CPEB1 coordinates alternative 3′-UTR formation with translational regulation", Nature, 495, pp.121~125 (2013)
32. Jenal M, "The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites", Cell, 149, pp.538~553 (2012)
33. Hsin-Sung Yeh, "Analyses of alternative polyadenylation: from old school biochemistry to high-throughput technologies", BMB Reports, 50(4), pp.201~207 (2017), 생화학분자생물학회
34. Fabian MR, "Regulation of mRNA translation and stability by microRNAs", Annu Rev Biochem, 79, pp.351~379 (2010)
35. Sandberg R, "Proliferating cells express mRNAs with shortened 3′ untranslated regions and fewer microRNA target sites", Science, 320, pp.1643~1647 (2008)
36. Boutet SC, "Alternative polyadenylation mediates microRNA regulation of muscle stem cell function", Cell Stem Cell, 10, pp.327~336 (2012)
37. Ciolli Mattioli C, "Alternative 3′ UTRs direct localization of functionally diverse protein isoforms in neuronal compartments", Nucleic Acids Res, 47, pp.2560~2573 (2019)
38. Berkovits BD, "Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization", Nature, 522, pp.363~367 (2015)
39. Mayr C, "Evolution and biological roles of alternative 3'UTRs", Trends Cell Biol, 26, pp.227~237 (2016)
40. Hoque M, "Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing", Nat Methods, 10, pp.133~139 (2013)
41. Rogers J, "Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin mu chain", Cell, 20, pp.303~312 (1980)
42. O'Loghlen A, "Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1", Exp Cell Res, 299, pp.343~355 (2004)
43. Lee SH, "Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia", Nature, 561, pp.127~131 (2018)
44. Guertin DA, "Defining the role of mTOR in cancer", Cancer Cell, 12, pp.9~22 (2007)
45. Hardie DG, "AMP-activated", SNF1 protein kinases : conserved guardians of cellular energy, 2007, pp.8, 774~785
46. Codogno P, "Autophagy and signaling : their role in cell survival and cell death", Cell Death Differ, 12(Suppl 2), pp.1509~1518 (2005)
47. Karar J, "PI3K", AKT, Front Mol Neurosci, pp.2011, 4[DOI]
48. Liu J, "The activation of mTOR pathway induced by inflammation accelerates the progression of atherosclerosis in hemodialysis patients", Int J Cardiol, 152, pp.S5~ (2011)
49. Jones RG, "MenTORing immunity : mTOR signaling in the development and function of tissue-resident immune cells", Immunity, 46, pp.730~742 (2017)
50. Kurdi A, "mTOR inhibition and cardiovascular diseases : dyslipidemia and atherosclerosis", Transplantation, 102, pp.S44~S46 (2018)
51. Xie J, "mTOR inhibitors in cancer therapy", F1000Res, 5, pp.2078~ (2016)
52. Richter JD, "Regulation of cap-dependent translation by eIF4E inhibitory proteins", Nature, 433, pp.477~480 (2005)
53. Thoreen CC, "A unifying model for mTORC1-mediated regulation of mRNA translation", Nature, 485, pp.109~113 (2012)
54. Mayer C, "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability", Genes Dev, 18, pp.423~434 (2004)
55. Ben-Sahra I, "mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle", Science, 351, pp.728~733 (2016)
56. Düvel K, "Activation of a metabolic gene regulatory network downstream of mTOR complex 1", Mol Cell, 39, pp.171~183 (2010)
57. Cunningham JT, "mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex", Nature, 450, pp.736~740 (2007)
58. Chang JW, "mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation", Nat Commun, 6, pp.7218~ (2015)
59. Shi Y, "Alternative polyadenylation : new insights from global analyses", RNA, 18, pp.2105~2117 (2012)
60. Fox-Walsh K, "A multiplex RNA-seq strategy to profile poly(A+)RNA : application to analysis of transcription response and 3′ end formation", Genomics, 98, pp.266~271 (2011)
61. Chang JW, "An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response", Nucleic Acids Res, 46, pp.5996~6008 (2018)
62. Passacantilli I, "hnRNPM guides an alternative splicing program in response to inhibition of the PI3K", AKT, Nucleic Acids Res, pp.2017, 45[DOI]
63. Lee G, "Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling", Cell, 171, pp.1545~1558 (2017)
64. Chang JW, "mTOR-regulated U2af1 tandem exon splicing specifies transcriptome features for translational control", Nucleic Acids Res, 47, pp.10373~10387 (2019)
65. Vogel C, "Insights into the regulation of protein abundance from proteomic and transcriptomic analyses", Nat Rev Genet, 13, pp.227~232 (2012)
66. Reyes A, "Alternative start and termination sites of transcription drive most transcript isoform differences across human tissues", Nucleic Acids Res, 46, pp.582~592 (2018)
67. Lerner T, "an overview of the C-to-U RNA editing machinery and its implication in human disease", Genes(Basel), 10, pp.13~ (2018)

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