본문 바로가기
KERD
논문KCI 등재

Toward the Clinical Application of Therapeutic Angiogenesis Against Pediatric Ischemic Retinopathy

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Therapeutic angiogenesis refers to strategies of inducing angiogenesis to treat diseases involving ischemic conditions. Historically, most attempts and achievements have been related to coronary and peripheral artery diseases. In this review, we propose the clinical application of therapeutic angiogenesis for the treatment of pediatric ischemic retinopathy, including retinopathy of prematurity, familial exudative retinopathy, and NDP-related retinopathy. These diseases are all characterized by the reduction of physiological angiogenesis and the following induction of pathological angiogenesis. Therapeutic angiogenesis, which supplements insufficient physiological angiogenesis, may be a therapeutic approach for ischemic conditions. Various molecules and modalities can be utilized to apply therapeutic angiogenesis for the treatment of ischemic retinopathy, as in coronary and peripheral artery diseases. Experiences with cardiovascular diseases provide a useful reference for the further clinical application of therapeutic angiogenesis in pediatric ischemic retinopathy. Recombinant proteins and gene therapy are powerful tools to deliver angiogenic factors to retinal tissues directly. Furthermore, endothelial progenitor or bone marrow-derived cells can be injected into the vitreous cavity of the eye for therapeutic angiogenesis. Intraocular injections are highly promising for the delivery of therapeutics for therapeutic angiogenesis. We expect that therapeutic angiogenesis will be a breakthrough in the treatment of pediatric ischemic retinopathy.

Abstract

Therapeutic angiogenesis refers to strategies of inducing angiogenesis to treat diseases involving ischemic conditions. Historically, most attempts and achievements have been related to coronary and peripheral artery diseases. In this review, we propose the clinical application of therapeutic angiogenesis for the treatment of pediatric ischemic retinopathy, including retinopathy of prematurity, familial exudative retinopathy, and NDP-related retinopathy. These diseases are all characterized by the reduction of physiological angiogenesis and the following induction of pathological angiogenesis. Therapeutic angiogenesis, which supplements insufficient physiological angiogenesis, may be a therapeutic approach for ischemic conditions. Various molecules and modalities can be utilized to apply therapeutic angiogenesis for the treatment of ischemic retinopathy, as in coronary and peripheral artery diseases. Experiences with cardiovascular diseases provide a useful reference for the further clinical application of therapeutic angiogenesis in pediatric ischemic retinopathy. Recombinant proteins and gene therapy are powerful tools to deliver angiogenic factors to retinal tissues directly. Furthermore, endothelial progenitor or bone marrow-derived cells can be injected into the vitreous cavity of the eye for therapeutic angiogenesis. Intraocular injections are highly promising for the delivery of therapeutics for therapeutic angiogenesis. We expect that therapeutic angiogenesis will be a breakthrough in the treatment of pediatric ischemic retinopathy.

참고문헌 (92)

  1. Höckel M, "Therapeutic angiogenesis", Arch Surg, 128, pp.423~429 (1993)
  2. Penn JS, "Oxygen-induced retinopathy in the rat", Basic Life Sci, 49, pp.1025~1028 (1988)
  3. Simons M, "Therapeutic angiogenesis in cardiovascular disease", Nat Rev Drug Discov, 2, pp.863~871 (2003)
  4. Losordo DW, "Therapeutic angiogenesis and vasculogenesis for ischemic disease : part II : cell-based therapies", Circulation, 109, pp.2692~2697 (2004)
  5. Losordo DW, "Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I : angiogenic cytokines", Circulation, 109, pp.2487~2491 (2004)
  6. Johnson T, "Approaches to therapeutic angiogenesis for ischemic heart disease", J Mol Med(Berl), 97, pp.141~151 (2019)
  7. Hartnett ME, "Mechanisms and management of retinopathy of prematurity", N Engl J Med, 367, pp.2515~2526 (2012)
  8. Palmer EA, "Incidence and early course of retinopathy of prematurity", Ophthalmology, 98, pp.1628~1640 (1991)
  9. Smith LE, "Oxygen-induced retinopathy in the mouse", Invest Ophthalmol Vis Sci, 35, pp.101~111 (1994)
  10. Connor KM, "Quantification of oxygen-induced retinopathy in the mouse : a model of vessel loss, vessel regrowth and pathological angiogenesis", Nat Protoc, 4, pp.1565~1573 (2009)
  11. Gilmour DF, "Familial exudative vitreoretinopathy and related retinopathies", Eye(Lond), 29, pp.1~14 (2015)
  12. Tauqeer Z, "Familial exudative vitreoretinopathy: pathophysiology, diagnosis, and management", Asia Pac J Ophthalmol(Phila), 7, pp.176~182 (2018)
  13. Pendergast SD, "Familial exudative vitreoretinopathy. Results of surgical management", Ophthalmology, 105, pp.1015~1023 (1998)
  14. Warden SM, "The Wnt signaling pathway in familial exudative vitreoretinopathy and Norrie disease", Semin Ophthalmol, 22, pp.211~217 (2007)
  15. Ye X, "Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization", Cell, 139, pp.285~298 (2009)
  16. Wang Y, "Norrin", Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity, 2012, pp.151, 1332~1344
  17. Potente M, "Basic and therapeutic aspects of angiogenesis", Cell, 146, pp.873~887 (2011)
  18. Chen ZY, "A mutation in the Norrie disease gene(NDP)associated with X-linked familial exudative vitreoretinopathy", Nat Genet, 5, pp.180~183 (1993)
  19. Kim JH, "Mutations of the Norrie gene in Korean ROP infants", Korean J Ophthalmol, 16, pp.93~96 (2002)
  20. Dickinson JL, "Mutations in the NDP gene : contribution to Norrie disease, familial exudative vitreoretinopathy and retinopathy of prematurity", Clin Exp Ophthalmol, 34, pp.682~688 (2006)
  21. Rathi S, "Mutation spectrum of NDP, FZD4 and TSPAN12 genes in Indian patients with retinopathy of prematurity", Br J Ophthalmol, 102, pp.276~281 (2018)
  22. Tang M, "Mutation spectrum of the LRP5, NDP, and TSPAN12 genes in Chinese patients with familial exudative vitreoretinopathy", Invest Ophthalmol Vis Sci, 58, pp.5949~5957 (2017)
  23. Li JK, "Spectrum of variants in 389 Chinese probands with familial exudative vitreoretinopathy", Invest Ophthalmol Vis Sci, 59, pp.5368~5381 (2018)
  24. Sims KB, "GeneReviews(R)" (1993), University of Washington
  25. Dong Hyun Jo, "How to Overcome Retinal Neuropathy: The Fight against Angiogenesisrelated Blindness", Archives of Pharmacal Research, 33(10), pp.1557~1565 (2010), 대한약학회
  26. Gariano RF, "Retinal angiogenesis in development and disease", Nature, 438, pp.960~966 (2005)
  27. Mintz-Hittner HA, "Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity", N Engl J Med, 364, pp.603~615 (2011)
  28. Tagami M, "Rapid regression of retinal hemorrhage and neovascularization in a case of familial exudative vitreoretinopathy treated with intravitreal bevacizumab", Graefes Arch Clin Exp Ophthalmol, 246, pp.1787~1789 (2008)
  29. Mansour SE, "The evolving treatment of diabetic retinopathy", Clin Ophthalmol, 14, pp.653~678 (2020)
  30. Hansson GK, "Inflammation, atherosclerosis, and coronary artery disease", N Engl J Med, 352, pp.1685~1695 (2005)
  31. Hiatt WR, "Medical treatment of peripheral arterial disease and claudication", N Engl J Med, 344, pp.1608~1621 (2001)
  32. Webster KA, "Therapeutic angiogenesis : a complex problem requiring a sophisticated approach", Cardiovasc Toxicol, 3, pp.283~298 (2003)
  33. Henry TD, "Therapeutic angiogenesis", BMJ, 318, pp.1536~1539 (1999)
  34. Bobek V, "Gene therapy of the ischemic lower limb--Therapeutic angiogenesis", Vascul Pharmacol, 44, pp.395~405 (2006)
  35. Schumacher B, "Induction of neoangiogenesis in ischemic myocardium by human growth factors : first clinical results of a new treatment of coronary heart disease", Circulation, 97, pp.645~650 (1998)
  36. Laham RJ, "Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery : results of a phase I randomized, double-blind, placebo-controlled trial", Circulation, 100, pp.1865~1871 (1999)
  37. Hendel RC, "Effect of intracoronary recombinant human vascular endothelial growth factor on myocardial perfusion : evidence for a dose-dependent effect", Circulation, 101, pp.118~121 (2000)
  38. Simons M, "Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2 : double-blind, randomized, controlled clinical trial", Circulation, 105, pp.788~793 (2002)
  39. Henry TD, "The VIVA trial : vascular endothelial growth factor in Ischemia for vascular angiogenesis", Circulation, 107, pp.1359~1365 (2003)
  40. Giacca M, "Virus-mediated gene transfer to induce therapeutic angiogenesis : where do we stand?", Int J Nanomedicine, 2, pp.527~540 (2007)
  41. Losordo DW, "Gene therapy for myocardial angiogenesis : initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia", Circulation, 98, pp.2800~2804 (1998)
  42. Rosengart TK, "Angiogenesis gene therapy : phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease", Circulation, 100, pp.468~474 (1999)
  43. Vale PR, "Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia", Circulation, 103, pp.2138~2143 (2001)
  44. Losordo DW, "Phase 1", 2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia, 2002, pp.105, 2012~2018
  45. Grines CL, "Angiogenic gene therapy(AGENT)trial in patients with stable angina pectoris", Circulation, 105, pp.1291~1297 (2002)
  46. Fan Y, "Therapeutic angiogenesis for brain ischemia : a brief review", J Neuroimmune Pharmacol, 2, pp.284~289 (2007)
  47. Goldberg JL, "UC blood hematopoietic stem cells and therapeutic angiogenesis", Cytotherapy, 9, pp.4~13 (2007)
  48. Assmus B, "Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction(TOPCARE-AMI)", Circulation, 106, pp.3009~3017 (2002)
  49. Strauer BE, "Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans", Circulation, 106, pp.1913~1918 (2002)
  50. Perin EC, "Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure", Circulation, 107, pp.2294~2302 (2003)
  51. Tse HF, "Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation", Lancet, 361, pp.47~49 (2003)
  52. Lazarous DF, "Basic fibroblast growth factor in patients with intermittent claudication : results of a phase I trial", J Am Coll Cardiol, 36, pp.1239~1244 (2000)
  53. Lederman RJ, "Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication(the TRAFFIC study) : a randomised trial", Lancet, 359, pp.2053~2058 (2002)
  54. Isner JM, "Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb", Lancet, 348, pp.370~374 (1996)
  55. Baumgartner I, "Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia", Circulation, 97, pp.1114~1123 (1998)
  56. Powell RJ, "Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia", Circulation, 118, pp.58~65 (2008)
  57. Mäkinen K, "Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery : a randomized, placebo-controlled, double-blinded phase II study", Mol Ther, 6, pp.127~133 (2002)
  58. Rajagopalan S, "Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease : a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication", Circulation, 108, pp.1933~1938 (2003)
  59. Tateishi-Yuyama E, "Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells : a pilot study and a randomised controlled trial", Lancet, 360, pp.427~435 (2002)
  60. Kastrup J, "Vascular growth factor and gene therapy to induce new vessels in the ischemic myocardium. Therapeutic angiogenesis", Scand Cardiovasc J, 35, pp.291~296 (2001)
  61. Post MJ, "Therapeutic angiogenesis in cardiology using protein formulations", Cardiovasc Res, 49, pp.522~531 (2001)
  62. Khurana R, "Insights from angiogenesis trials using fibroblast growth factor for advanced arteriosclerotic disease", Trends Cardiovasc Med, 13, pp.116~122 (2003)
  63. Dor Y, "Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy", EMBO J, 21, pp.1939~1947 (2002)
  64. Schwarz ER, "Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor(VEGF)in a myocardial infarction model in the rat--angiogenesis and angioma formation", J Am Coll Cardiol, 35, pp.1323~1330 (2000)
  65. Syed IS, "Therapeutic angiogenesis : a biologic bypass", Cardiology, 101, pp.131~143 (2004)
  66. Idris NM, "Therapeutic angiogenesis for treatment of peripheral vascular disease", Growth Factors, 22, pp.269~279 (2004)
  67. Annex BH, "Growth factor-induced therapeutic angiogenesis in the heart : protein therapy", Cardiovasc Res, 65, pp.649~655 (2005)
  68. Markkanen JE, "Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart--gene therapy", Cardiovasc Res, 65, pp.656~664 (2005)
  69. Emanueli C, "Therapeutic angiogenesis : translating experimental concepts to medically relevant goals", Vascul Pharmacol, 45, pp.334~339 (2006)
  70. Mandai M, "Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration", N Engl J Med, 376, pp.1038~1046 (2017)
  71. Bennett J, "Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations : a follow-on phase 1 trial", Lancet, 388, pp.661~672 (2016)
  72. Sato T, "Simultaneous analyses of vitreous levels of 27 cytokines in eyes with retinopathy of prematurity", Ophthalmology, 116, pp.2165~2169 (2009)
  73. Zhao M, "Expression of total vascular endothelial growth factor and the anti-angiogenic VEGF 165 b isoform in the vitreous of patients with retinopathy of prematurity", Chin Med J(Engl), 128, pp.2505~2509 (2015)
  74. Yenihayat F, "Vitreous IL-8 and VEGF levels in diabetic macular edema with or without subretinal fluid", Int Ophthalmol, 39, pp.821~828 (2019)
  75. Citirik M, "Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy", Ophthalmic Res, 47, pp.7~12 (2012)
  76. Ohlmann A, "Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice", J Neurosci, 25, pp.1701~1710 (2005)
  77. Ohlmann A, "Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice", J Neurosci, 30, pp.183~193 (2010)
  78. Tokunaga CC, "Retinal vascular rescue of oxygen-induced retinopathy in mice by norrin", Invest Ophthalmol Vis Sci, 54, pp.222~229 (2013)
  79. Zeilbeck LF, "Norrin mediates angiogenic properties via the induction of insulin-like growth factor-1", Exp Eye Res, 145, pp.317~326 (2016)
  80. Cho CH, "Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis", Proc Natl Acad Sci U S A, 101, pp.5553~5558 (2004)
  81. Lee J, "Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy", Sci Transl Med, 5, pp.203~ (2013)
  82. Butler JM, "SDF-1 is both necessary and sufficient to promote proliferative retinopathy", J Clin Invest, 115, pp.86~93 (2005)
  83. Chang KH, "IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development", Proc Natl Acad Sci U S A, 104, pp.10595~10600 (2007)
  84. Caballero S, "Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells", Diabetes, 56, pp.960~967 (2007)
  85. Medina RJ, "Outgrowth endothelial cells : characterization and their potential for reversing ischemic retinopathy", Invest Ophthalmol Vis Sci, 51, pp.5906~5913 (2010)
  86. Prasain N, "Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells", Nat Biotechnol, 32, pp.1151~1157 (2014)
  87. Wang D, "Effect of endothelial progenitor cells derived from human umbilical cord blood on oxygen-induced retinopathy in mice by intravitreal transplantation", Int J Ophthalmol, 9, pp.1578~1583 (2016)
  88. Li Calzi S, "Progenitor cell combination normalizes retinal vascular development in the oxygen-induced retinopathy(OIR)model", JCI Insight, 4, pp.e129224~ (2019)
  89. Otani A, "Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis", Nat Med, 8, pp.1004~1010 (2002)
  90. Lin Y, "Origins of circulating endothelial cells and endothelial outgrowth from blood", J Clin Invest, 105, pp.71~77 (2000)
  91. O'Leary OE, "The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic", Exp Eye Res, 182, pp.144~155 (2019)
  92. Nomi M, "Role of growth factors and endothelial cells in therapeutic angiogenesis and tissue engineering", Curr Stem Cell Res Ther, 1, pp.333~343 (2006)

관련 논문AI추천

이 간행물의 다른 논문 (6건)