약물 상호작용 모니터링 프로그램의 임상적 유용성 평가
Clinical Usefulness Evaluation of Computerized Drug-Drug Interaction Program
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Polypharmacy (multiple drug use) is considered one of the major risk factors in drugdrug interactions and is a common problem among the elderly patients. It can lead to noncompliance or even discontinuation of the therapy. The purpose of this study was to assess the clinical usefulness, the prevalence, and severity of drug-drug interaction induced ADR (adverse drug reaction) in a long-term care hospital. A retrospective, observational review of electronic medical records and pharmacist interviews with patients were performed. The dataset was analyzed for ADR causality, ADR severity, patient demographic profiles and ADR related characteristics. 324 patients were included (156 males, 168 females), if they were prescribed medication with potential drug-drug interactions, between 1 January 2014 and 31 December 2014 (12 months total). Most patients (80%) were above 65 years old. The patients had a total of 1,680 drugs (average 5.2 drugs per patient), and 932 potential drug-drug interactions (average 2.89 per patient). The most common clinicaly useful ADRs were 17 peptic ulcer and a myopathy. These ADRs were in patients over 65 years age. This indicates the need for rigid ADR monitoring to ensure safety for long-term care patients.
Abstract
Polypharmacy (multiple drug use) is considered one of the major risk factors in drugdrug interactions and is a common problem among the elderly patients. It can lead to noncompliance or even discontinuation of the therapy. The purpose of this study was to assess the clinical usefulness, the prevalence, and severity of drug-drug interaction induced ADR (adverse drug reaction) in a long-term care hospital. A retrospective, observational review of electronic medical records and pharmacist interviews with patients were performed. The dataset was analyzed for ADR causality, ADR severity, patient demographic profiles and ADR related characteristics. 324 patients were included (156 males, 168 females), if they were prescribed medication with potential drug-drug interactions, between 1 January 2014 and 31 December 2014 (12 months total). Most patients (80%) were above 65 years old. The patients had a total of 1,680 drugs (average 5.2 drugs per patient), and 932 potential drug-drug interactions (average 2.89 per patient). The most common clinicaly useful ADRs were 17 peptic ulcer and a myopathy. These ADRs were in patients over 65 years age. This indicates the need for rigid ADR monitoring to ensure safety for long-term care patients.
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