인공관절치환술 후 예방적 항혈전제 사용
Thromboprophylaxis after Arthroplasty
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Background : Antithrombotic prophylaxis is recommended after knee and hip arthroplasty to prevent venous thromboembolism. The purpose of this study was to investigate the current trend of thromboprophylaxis after knee and hip arthroplasty in South Korea. Methods : We analyzed Aged Patient Sample data from 2016 compiled by the Health Insurance Review & Assessment Service (HIRA-APS-2016), to estimate the rate of pharmacological thromboprophylaxis. We also examined the factors influencing the utilization of thromboprophylaxis, according to patient and institutional characteristics. Results : Thirty-seven percent of patients underwent thromboprophylaxis after knee and hip arthroplasty. The most utilized antithrombotic agent was rivaroxaban (67.4%), followed by enoxaparin (16.1%). In terms of population characteristics, factors such as older age, male gender, health insurance type (Medical Aid/Veterans), and comorbidities (peripheral vascular disease and stroke) were identified as risk factors for underuse of thromboprophylaxis. Conclusions : Less than half of the post-knee and hip arthroplasty patients received thromboprophylaxis. The use of non-vitamin K oral anticoagulants to replace conventional low molecular weight heparin and warfarin has increased.
Abstract
Background : Antithrombotic prophylaxis is recommended after knee and hip arthroplasty to prevent venous thromboembolism. The purpose of this study was to investigate the current trend of thromboprophylaxis after knee and hip arthroplasty in South Korea. Methods : We analyzed Aged Patient Sample data from 2016 compiled by the Health Insurance Review & Assessment Service (HIRA-APS-2016), to estimate the rate of pharmacological thromboprophylaxis. We also examined the factors influencing the utilization of thromboprophylaxis, according to patient and institutional characteristics. Results : Thirty-seven percent of patients underwent thromboprophylaxis after knee and hip arthroplasty. The most utilized antithrombotic agent was rivaroxaban (67.4%), followed by enoxaparin (16.1%). In terms of population characteristics, factors such as older age, male gender, health insurance type (Medical Aid/Veterans), and comorbidities (peripheral vascular disease and stroke) were identified as risk factors for underuse of thromboprophylaxis. Conclusions : Less than half of the post-knee and hip arthroplasty patients received thromboprophylaxis. The use of non-vitamin K oral anticoagulants to replace conventional low molecular weight heparin and warfarin has increased.
참고문헌 (20)
- 슬관절 혹은 고관절 인공관절치환술 환자의 혈전색전증 예방을 위한 항응고제요법 비교연구, "안정훈", 한국보건의료연구원, ~ (2012)
- Anderson FA, "A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study", Archives of internal medicine, 151(5), pp.933~938 (1991)
- Geerts WH, "Prevention of venous thromboembolism:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines", Chest, 133(6 Suppl), pp.381s~453s (2008)
- Kim YH, "Incidence and natural history of deep-vein thrombosis after total knee arthroplasty. A prospective, randomised study", The Journal of bone and joint surgery British volume, 84(4), pp.566~570 (2002)
- Piovella F, "Deep-vein thrombosis rates after major orthopedic surgery in Asia. An epidemiological study based on postoperative screening with centrally adjudicated bilateral venography", Journal of thrombosis and haemostasis, 3(12), pp.2664~2670 (2005)
- Leizorovicz A, "Epidemiology of venous thromboembolism in Asian patients undergoing major orthopedic surgery without thromboprophylaxis. The SMART study", Journal of thrombosis and haemostasis, 3(12), pp.28~34 (2005)
- Park YS, "Guideline for the Prophylaxis of Venous Thromboembolism in Hip Surgery Patients", J Korean Orthop Assoc, 46(2), pp.95~98 (2011)
- Mont MA, "AAOS clinical practice guideline : preventing venous thromboembolic disease in patients undergoing elective hip and knee arthroplasty", The Journal of the American Academy of Orthopaedic Surgeons, 19(12), pp.777~778 (2011)
- Falck-Ytter Y, "Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis", American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 141(2Suppl), pp.e278S~e325S (2012)
- 방수미, "Prevention of Venous Thromboembolism, 2nd Edition: Korean Society of Thrombosis and Hemostasis Evidence-Based Clinical Practice Guidelines", Journal of Korean Medical Science, 29(2), pp.164~171 (2014), 대한의학회
- Yhim HY, "Incidence of venous thromboembolism following major surgery in Korea : from the Health Insurance Review and Assessment Service database", Journal of thrombosis and haemostasis, 12(7), pp.1035~1043 (2014)
- Hill J, "Reducing the risk of venous thromboembolism in patients admitted to hospital: summary of NICE guidance", BMJ, 340, pp.c95~ (2010)
- Kim S, "Trends of thromboprophylaxis and complications after major lower limb orthopaedic surgeries in Korea : National Health Insurance Claim Data", Thrombosis research, 155, pp.48~52 (2017)
- Yhim HY, "Pharmacological thromboprophylaxis and its impact on venous thromboembolism following total knee and hip arthroplasty in Korea: A nationwide population-based study", PloS one, 12(5), pp.e0178214~ (2017)
- Nam Ki Kim, "Prophylaxis for Venous Thromboembolism Following Total Knee Arthroplasty: A Survey of Korean Knee Surgeons", Knee Surgery and Related Research, 28(3), pp.207~212 (2016), 대한슬관절학회
- 고인준, "Is Routine Thromboprophylaxis Needed in Korean Patients Undergoing Unicompartmental Knee Arthroplasty?", Journal of Korean Medical Science, 31(3), pp.443~448 (2016), 대한의학회
- 김강일, "Thromboprophylaxis for Deep Vein Thrombosis and Pulmonary Embolism after Total Joint Arthroplasty in a Low Incidence Population", Knee Surgery and Related Research, 25(2), pp.43~53 (2013), 대한슬관절학회
- 서정탁, "슬관절 인공관절 전치환술 후 심부정맥혈전증-발생 빈도와 임상적 위험인자와의 상관관계-", Knee Surgery and Related Research, 22(4), pp.270~277 (2010), 대한슬관절학회
- 이상훈, "Venous Thromboembolism Following Hip and Knee Replacement Arthroplasty in Korea: A Nationwide Study Based on Claims Registry", Journal of Korean Medical Science, 31(1), pp.80~88 (2016), 대한의학회
- Liew NC, "Postoperative venous thromboembolism in Asia : a critical appraisal of its incidence", Asian journal of surgery, 26(3), pp.154~158 (2003)
