The Present Status of Drug Administration via Enteral Route in a Tertiary Hospital : A Cross-Sectional Study
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Background : During administration of drugs via the enteral tube, potential pharmacokinetic or pharmacological changes in orally-administered drugs must be considered. Pharmacists play a critical role in the process of medication review prior to medication administration, which includes the identification of the site of drug absorption and tube flushing. Methods : We conducted this retrospective, cross-sectional, descriptive study to evaluate the following international recommendations: flushing between 15 and 30 mL before drug administration and after drug use. The state of water supply through the tube and that of all fluids via the intravenous route were identified, and the relationship between the state of supply of drugs was evaluated. Additionally, the tube position on abdominal radiograph was assessed to identify the drug absorption site, and information on the absorption site was provided by reviewing literature. Results : The average amount of water supplied through the feeding tube averaged to 344.29 mL (SD; 296.54) daily. The absorption sites of the medications were identified as stomach (66, 78.6%), duodenal (4, 4.8%) and jejunum (1, 1.2%). The number of drugs absorbed by the duodenum and jejunum was 55 (7.5%), and for most drugs, no information was available on the absorption sites. Conclusion : It is necessary to appropriate water flushing according to medication to prevent tube clogging. The evaluation of drug response is required due to the lack of information on drug absorption sites.
Abstract
Background : During administration of drugs via the enteral tube, potential pharmacokinetic or pharmacological changes in orally-administered drugs must be considered. Pharmacists play a critical role in the process of medication review prior to medication administration, which includes the identification of the site of drug absorption and tube flushing. Methods : We conducted this retrospective, cross-sectional, descriptive study to evaluate the following international recommendations: flushing between 15 and 30 mL before drug administration and after drug use. The state of water supply through the tube and that of all fluids via the intravenous route were identified, and the relationship between the state of supply of drugs was evaluated. Additionally, the tube position on abdominal radiograph was assessed to identify the drug absorption site, and information on the absorption site was provided by reviewing literature. Results : The average amount of water supplied through the feeding tube averaged to 344.29 mL (SD; 296.54) daily. The absorption sites of the medications were identified as stomach (66, 78.6%), duodenal (4, 4.8%) and jejunum (1, 1.2%). The number of drugs absorbed by the duodenum and jejunum was 55 (7.5%), and for most drugs, no information was available on the absorption sites. Conclusion : It is necessary to appropriate water flushing according to medication to prevent tube clogging. The evaluation of drug response is required due to the lack of information on drug absorption sites.
참고문헌 (16)
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