Applicability of Artificial Intelligence in the Field of Clinical Lipidology: A Narrative Review
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The development of advanced technologies in artificial intelligence (AI) has expanded its applications across various fields. Machine learning (ML), a subcategory of AI, enables computers to recognize patterns within extensive datasets. Furthermore, deep learning, a specialized form of ML, processes inputs through neural network architectures inspired by biological processes. The field of clinical lipidology has experienced significant growth over the past few years, and recently, it has begun to intersect with AI. Consequently, the purpose of this narrative review is to examine the applications of AI in clinical lipidology. This review evaluates various publications concerning the diagnosis of familial hypercholesterolemia, estimation of low-density lipoprotein cholesterol (LDL-C) levels, prediction of lipid goal attainment, challenges associated with statin use, and the influence of cardiometabolic and dietary factors on the discordance between apolipoprotein B and LDL-C. Given the concerns surrounding AI techniques, such as ethical dilemmas, opacity, limited reproducibility, and methodological constraints, it is prudent to establish a framework that enables the medical community to accurately interpret and utilize these emerging technological tools.
Abstract
The development of advanced technologies in artificial intelligence (AI) has expanded its applications across various fields. Machine learning (ML), a subcategory of AI, enables computers to recognize patterns within extensive datasets. Furthermore, deep learning, a specialized form of ML, processes inputs through neural network architectures inspired by biological processes. The field of clinical lipidology has experienced significant growth over the past few years, and recently, it has begun to intersect with AI. Consequently, the purpose of this narrative review is to examine the applications of AI in clinical lipidology. This review evaluates various publications concerning the diagnosis of familial hypercholesterolemia, estimation of low-density lipoprotein cholesterol (LDL-C) levels, prediction of lipid goal attainment, challenges associated with statin use, and the influence of cardiometabolic and dietary factors on the discordance between apolipoprotein B and LDL-C. Given the concerns surrounding AI techniques, such as ethical dilemmas, opacity, limited reproducibility, and methodological constraints, it is prudent to establish a framework that enables the medical community to accurately interpret and utilize these emerging technological tools.
참고문헌 (37)
- Parhofer KG, "Update lipidology : evidence-based treatment of dyslipidemia", Inn Med(Heidelb), 64, pp.611~621 (2023)
- Tang L, "Medical artificial intelligence ethics : a systematic review of empirical studies", Digit Health, 9, pp.20552076231186064~ (2023)
- Gomes MA, "Transforming healthcare with big data analytics : technologies, techniques and prospects", J Med Eng Technol, 47, pp.1~11 (2023)
- Hong L, "Big data in health care : applications and challenges", Data Inf Manag, 2, pp.175~197 (2018)
- Kallapur A, "Pharmacotherapy in familial hypercholesterolemia-current state and emerging paradigms", Trends Cardiovasc Med, 33, pp.170~179 (2023)
- Berberich AJ, "The complex molecular genetics of familial hypercholesterolaemia", Nat Rev Cardiol, 16, pp.9~20 (2019)
- Hesse R, "Familial hypercholesterolemia identification by machine learning using lipid profile data performs as well as clinical diagnostic criteria", Circ Genom Precis Med, 15, pp.e003324~ (2022)
- Pina A, "Virtual genetic diagnosis for familial hypercholesterolemia powered by machine learning", Eur J Prev Cardiol, 27, pp.1639~1646 (2020)
- Nolde JM, "Neural network modelling for predicting gene variants causative of familial hypercholesterolaemia in the clinic", Heart Lung Circ, 32, pp.e44~ (2023)
- Banda JM, "Finding missed cases of familial hypercholesterolemia in health systems using machine learning", NPJ Digit Med, 2, pp.23~ (2019)
- Rossouw HM, "Comparability of 11 different equations for estimating LDL cholesterol on different analysers", Clin Chem Lab Med, 59, pp.1930~1943 (2021)
- Oh GC, "Estimation of low-density lipoprotein cholesterol levels using machine learning", Int J Cardiol, 352, pp.144~149 (2022)
- Barakett-Hamade V, "Is machine learning-derived low-density lipoprotein cholesterol estimation more reliable than standard closed form equations? Insights from a laboratory database by comparison with a direct homogeneous assay", Clin Chim Acta, 519, pp.220~226 (2021)
- Singh G, "Comparing a novel machine learning method to the Friedewald formula and Martin-Hopkins equation for low-density lipoprotein estimation", PLoS One, 15, pp.e0239934~ (2020)
- Ghayad JP, "Prospective validation of a machine learning model for low-density lipoprotein cholesterol estimation", Lab Med, 53, pp.629~635 (2022)
- Hidekazu I, "Dataset dependency of low-density lipoprotein-cholesterol estimation by machine learning", Ann Clin Biochem, 60, pp.396~405 (2023)
- Kwon YJ, "Comparison of a machine learning method and various equations for estimating low-density lipoprotein cholesterol in Korean populations", Front Cardiovasc Med, 9, pp.824574~ (2022)
- Mach F, "2019 ESC", EAS Guidelines for the management of dyslipidaemias : lipid modification to reduce cardiovascular risk, 2020, pp.41, 111~188
- Visseren FL, "2021 ESC Guidelines on cardiovascular disease prevention in clinical practice", Eur J Prev Cardiol, 29, pp.5~115 (2022)
- Ersbøll AK, "Trends in low-density lipoprotein cholesterol goal achievement and changes in lipid-lowering therapy after incident atherosclerotic cardiovascular disease : Danish cohort study", PLoS One, 18, pp.e0286376~ (2023)
- Masi D, "Uncovering predictors of lipid goal attainment in type 2 diabetes outpatients using logic learning machine : insights from the AMD annals and AMD artificial intelligence study group", J Clin Med, 12, pp.4095~ (2023)
- Bytyçi I, "Prevalence of statin intolerance : a meta-analysis", Eur Heart J, 43, pp.3213~3223 (2022)
- Penson PE, "Introducing the ‘Drucebo’ effect in statin therapy : a systematic review of studies comparing reported rates of statin-associated muscle symptoms, under blinded and open-label conditions", J Cachexia Sarcopenia Muscle, 9, pp.1023~1033 (2018)
- Somani S, "Artificial intelligence-enabled analysis of statin-related topics and sentiments on social media", JAMA Netw Open, 6, pp.e239747~ (2023)
- Sarraju A, "Using deep learning-based natural language processing to identify reasons for statin nonuse in patients with atherosclerotic cardiovascular disease", Commun Med(Lond), 2, pp.88~ (2022)
- Sarraju A, "Identifying reasons for statin nonuse in patients with diabetes using deep learning of electronic health records", J Am Heart Assoc, 12, pp.e028120~ (2023)
- Mostaza JM, "Main barriers in the management of dyslipidaemias: Intolerants", Clin Investig Arterioscler, 33(Suppl 1), pp.40~45 (2021)
- Glavinovic T, "Physiological bases for the superiority of apolipoprotein B over low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol as a marker of cardiovascular risk", J Am Heart Assoc, 11, pp.e025858~ (2022)
- Sniderman AD, "Apolipoprotein B particles and cardiovascular disease : a narrative review", JAMA Cardiol, 4, pp.1287~1295 (2019)
- Webb RJ, "The role of adiposity, diet and inflammation on the discordance between LDL-C and apolipoprotein B", Nutr Metab Cardiovasc Dis, 32, pp.605~615 (2022)
- Masson W, "Discordant lipid pattern and carotid atherosclerotic plaque. Importance of remnant cholesterol", Arq Bras Cardiol, 108, pp.526~532 (2017)
- Masson W, "Lipid discordance and carotid plaque in obese patients in primary prevention", Endocrinol Diabetes Nutr(Engl Ed), 65, pp.39~44 (2018)
- Kayaalp M, "Patient privacy in the era of big data", Balkan Med J, 35, pp.8~17 (2018)
- Wachter S, "Counterfactual explanations without opening the black box : automated decisions and the GDPR", Harv J Law Technol, 31, pp.841~887 (2018)
- Ley C, "Machine learning and conventional statistics : making sense of the differences", Knee Surg Sports Traumatol Arthrosc, 30, pp.753~757 (2022)
- Sahni NR, "Artificial intelligence in U. S. health care delivery", N Engl J Med, 389, pp.348~358 (2023)
- Vollmer S, "Machine learning and artificial intelligence research for patient benefit : 20 critical questions on transparency, replicability, ethics, and effectiveness", BMJ, 368, pp.l6927~ (2020)
