The Effect of Evening Primrose Oil for the Prevention of Xerotic Cheilitis in Acne Patients Being Treated with Isotretinoin: A Pilot Study
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Background: The most common adverse effects of oralisotretinoin are cheilitis, skin dryness, dry eyes, andconjunctivitis, whereas evening primrose oil (EPO) is knownto improve skin moisture and transepidermal water loss(TEWL) in healthy adults and atopic patients. Objective: Toevaluate the clinical efficacy and safety of EPO in preventingxerotic cheilitis in acne patients being treated with oralisotretinoin. Methods: Forty Korean volunteers of Fitzpatrickskin types III and IV, having moderate acne, were enrolledand randomized to receive either isotretinoin with orwithout EPO for 8 weeks. The efficacy of treatment wasevaluated on the basis of global acne grading system scores,number of inflammatory and noninflammatory lesions,TEWL, corneometry, physician’s global assessment, andpatient satisfaction. Results: The results after 8 weeks oftreatment showed that the TEWL of the lip increased significantlyduring isotretinoin treatment, whereas the TEWLof the hand dorsum showed no significant change. Theincrease of the TEWL of the lip was more definite in thecontrol group than in the experimental group. The numberof acne lesions decreased significantly in both groups, andthere were no differences between them. Conclusion: Ourstudy suggests that the addition of EPO improved xeroticcheilitis in acne patients being treated with oral isotretinoin. However, besides TEWL and corneometry assessments,additional studies are required for a complete understandingof the role of EPO in xerotic cheilitis in acne patients beingtreated with oral isotretinoin.
Abstract
Background: The most common adverse effects of oralisotretinoin are cheilitis, skin dryness, dry eyes, andconjunctivitis, whereas evening primrose oil (EPO) is knownto improve skin moisture and transepidermal water loss(TEWL) in healthy adults and atopic patients. Objective: Toevaluate the clinical efficacy and safety of EPO in preventingxerotic cheilitis in acne patients being treated with oralisotretinoin. Methods: Forty Korean volunteers of Fitzpatrickskin types III and IV, having moderate acne, were enrolledand randomized to receive either isotretinoin with orwithout EPO for 8 weeks. The efficacy of treatment wasevaluated on the basis of global acne grading system scores,number of inflammatory and noninflammatory lesions,TEWL, corneometry, physician’s global assessment, andpatient satisfaction. Results: The results after 8 weeks oftreatment showed that the TEWL of the lip increased significantlyduring isotretinoin treatment, whereas the TEWLof the hand dorsum showed no significant change. Theincrease of the TEWL of the lip was more definite in thecontrol group than in the experimental group. The numberof acne lesions decreased significantly in both groups, andthere were no differences between them. Conclusion: Ourstudy suggests that the addition of EPO improved xeroticcheilitis in acne patients being treated with oral isotretinoin. However, besides TEWL and corneometry assessments,additional studies are required for a complete understandingof the role of EPO in xerotic cheilitis in acne patients beingtreated with oral isotretinoin.
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