Treatment of Patients with Refractory Atopic Dermatitis Sensitized to House Dust Mites by Using Sublingual Allergen Immunotherapy
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Even though atopic dermatitis (AD) is one of the most commonchronic inflammatory skin diseases, its treatment remainsa challenge in clinical practice, with most approacheslimited to symptomatic, unspecific anti-inflammatory, or immunosuppressivetreatments. Many studies have shown ADto have multiple causes that activate complex immunologicaland inflammatory pathways. However, aeroallergens,and especially the house dust mite (HDM), play a relevantrole in the elicitation or exacerbation of eczematous lesionsin many AD patients. Accordingly, allergen-specificimmunotherapy has been used in AD patients with the aimof redirecting inappropriate immune responses. Here, we reportthree cases of refractory AD sensitized to HDM whowere treated with sublingual immunotherapy.
Abstract
Even though atopic dermatitis (AD) is one of the most commonchronic inflammatory skin diseases, its treatment remainsa challenge in clinical practice, with most approacheslimited to symptomatic, unspecific anti-inflammatory, or immunosuppressivetreatments. Many studies have shown ADto have multiple causes that activate complex immunologicaland inflammatory pathways. However, aeroallergens,and especially the house dust mite (HDM), play a relevantrole in the elicitation or exacerbation of eczematous lesionsin many AD patients. Accordingly, allergen-specificimmunotherapy has been used in AD patients with the aimof redirecting inappropriate immune responses. Here, we reportthree cases of refractory AD sensitized to HDM whowere treated with sublingual immunotherapy.
참고문헌 (15)
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