The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort. Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles. Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction. Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted. Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.
Abstract
Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort. Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles. Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction. Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted. Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.
참고문헌 (27)
- Rinaldi A, "Healing beauty? More biotechnology cosmetic products that claim drug-like properties reach the market", EMBO Rep, 9, pp.1073~1077 (2008)
- Ooe M, "Comparative evaluation of wrinkle treatments", Aesthetic Plast Surg, 37, pp.424~433 (2013)
- Narayan RJ, "Transdermal delivery of insulin via microneedles", J Biomed Nanotechnol, 10, pp.2244~2260 (2014)
- Farage MA, "Functional and physiological characteristics of the aging skin", Aging Clin Exp Res, 20, pp.195~200 (2008)
- Chauhan P, "Modeling signaling pathways leading to wrinkle formation: identification of the skin aging target", Indian J Dermatol Venereol Leprol, 75, pp.463~468 (2009)
- Anchan RM, "EGF and TGF-alpha stimulate retinal neuroepithelial cell proliferation in vitro", Neuron, 6, pp.923~936 (1991)
- Schlessinger J, "Regulation of cell proliferation by epidermal growth factor", CRC Crit Rev Biochem, 14, pp.93~111 (1983)
- Elias PM, "The permeability barrier in mammalian epidermis", J Cell Biol, 65, pp.180~191 (1975)
- Elias PM, "Epidermal permeability barrier: transformation of lamellar granule-disks into intercellular sheets by a membrane fusion process", J Invest Dermatol, 88, pp.459~460 (1987)
- An JJ, "Protective effects of skin permeable epidermal and fibroblast growth factor against ultraviolet-induced skin damage and human skin wrinkles", J Cosmet Dermatol, 12, pp.287~295 (2013)
- Elias PM, "Epidermal lipids, barrier function, and desquamation", J Invest Dermatol, (80 Suppl), pp.44s~49s (1983)
- Prausnitz MR, "Microneedles for transdermal drug delivery", Adv Drug Deliv Rev, 56, pp.581~587 (2004)
- van der Maaden K, "Microneedle technologies for (trans)dermal drug and vaccine delivery", J Control Release, 161, pp.645~655 (2012)
- Doraiswamy A, "Fabrication of microneedles using two photon polymerization for transdermal delivery of nanomaterials", J Nanosci Nanotechnol, 10, pp.6305~6312 (2010)
- Carruthers A, "A validated grading scale for crow's feet", Dermatol Surg, (34 Suppl 2), pp.S173~S178 (2008)
- Gilchrest BA, "A review of skin ageing and its medical therapy", Br J Dermatol, 135, pp.867~875 (1996)
- Binstock RH, "Anti-aging medicine and research: a realm of conflict and profound societal implications", J Gerontol A Biol Sci Med Sci, 59, pp.B523~B533 (2004)
- Kogan A, "Microemulsions as transdermal drug delivery vehicles", Adv Colloid Interface Sci, 123-126, pp.369~385 (2006)
- Schramm J, "Transdermal drug delivery by jet injectors: energetics of jet formation and penetration", Pharm Res, 19, pp.1673~1679 (2002)
- Tokudome Y, "Enhancement of skin penetration of hydrophilic and lipophilic compounds by pH-sensitive liposomes", J Pharm Pharm Sci, 18, pp.249~257 (2015)
- Paudel KS, "Challenges and opportunities in dermal", transdermal delivery, 2010, pp.1, 109~131
- Cai B, "Bioceramic microneedles with flexible and self-swelling substrate", Eur J Pharm Biopharm, 94, pp.404~410 (2015)
- Chu LY, "Fabrication of dissolving polymer microneedles for controlled drug encapsulation and delivery: bubble and pedestal microneedle designs", J Pharm Sci, 99, pp.4228~4238 (2010)
- Donnelly RF, "Hydrogel-forming microneedle arrays can be effectively inserted in skin by self-application:a pilot study centred on pharmacist intervention and a patient information leaflet", Pharm Res, 31, pp.1989~1999 (2014)
- Kaur M, "Microneedleassisted delivery of verapamil hydrochloride and amlodipine besylate", Eur J Pharm Biopharm, 86, pp.284~291 (2014)
- Ita K, "Transdermal delivery of drugs with microneedlespotential and challenges", Pharmaceutics, 7, pp.90~105 (2015)
- 박지훈, "생분해성 마이크로니들 패치(Biodegradable Microneedle Patch)를 이용한 눈가 주름의 개선에 관한 연구", 대한피부과학회지, 52(9), pp.597~607 (2014), 대한피부과학회