Acral Lentiginous Melanoma, Indolent Subtype Diagnosed by En Bloc Excision: A Case Report
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Nail unit melanoma is a type of acral lentiginous melanoma and requires histopathologic examination for a confirmed diagnosis. However, inadequate biopsy techniques make definitive diagnosis difficult. A 61-year-old man presented with progressive nail pigmentation for 15 years, which was clinically highly suspicious for malignancy. Acral lentiginous melanoma was not detected in punch and longitudinal biopsy specimens, but en bloc excision tissue revealed melanoma. Acral lentiginous melanoma is known to have a heterogeneous pathologic manifestation depending on the pigmented region and the time it takes to progress. In this regard, en bloc excision can be considered as a first-line biopsy technique to diagnose acral lentiginous melanoma, indolent subtype.
Abstract
Nail unit melanoma is a type of acral lentiginous melanoma and requires histopathologic examination for a confirmed diagnosis. However, inadequate biopsy techniques make definitive diagnosis difficult. A 61-year-old man presented with progressive nail pigmentation for 15 years, which was clinically highly suspicious for malignancy. Acral lentiginous melanoma was not detected in punch and longitudinal biopsy specimens, but en bloc excision tissue revealed melanoma. Acral lentiginous melanoma is known to have a heterogeneous pathologic manifestation depending on the pigmented region and the time it takes to progress. In this regard, en bloc excision can be considered as a first-line biopsy technique to diagnose acral lentiginous melanoma, indolent subtype.
참고문헌 (15)
- Dawber RP, "The spectrum of malignant melanoma of the nail apparatus", Semin Dermatol, 10, pp.82~87 (1991)
- Ishihara K, "Updated statistical data for malignant melanoma in Japan", Int J Clin Oncol, 6, pp.109~116 (2001)
- Kim JH, "Site distribution of cutaneous melanoma in South Korea: a retrospective study at a single tertiary institution", Int J Dermatol, 54, pp.e38~e39 (2015)
- Tan KB, "Subungual melanoma: a study of 124cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting", Am J Surg Pathol, 31, pp.1902~1912 (2007)
- Baran R, "Longitudinal melanonychia (melanonychia striata): diagnosis and management", J Am Acad Dermatol, 21, pp.1165~1175 (1989)
- Levit EK, "The ABC rule for clinical detection of subungual melanoma", J Am Acad Dermatol, 42, pp.269~274 (2000)
- Park HS, "Acral lentiginous melanoma in situ: a diagnostic and management challenge", Cancers (Basel), 2, pp.642~652 (2010)
- Kim JY, "Acral lentiginous melanoma: indolent subtype with long radial growth phase", Am J Dermatopathol, 36, pp.142~147 (2014)
- 이동윤, "Variable Sized Cellular Remnants in the Nail Plate of Longitudinal Melanonychia: Evidence of Subungual Melanoma", Annals of Dermatology, 27(3), pp.328~329 (2015), 대한피부과학회
- Phan A, "Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population", Br J Dermatol, 162, pp.765~771 (2010)
- Izumi M, "Subungual melanoma: histological examination of 50 cases from early stage to bone invasion", J Dermatol, 35, pp.695~703 (2008)
- 신현태, "A Case of Subungual Melanoma with Tumor Invasion Sparing the Nail Matrix Dermis", Annals of Dermatology, 26(5), pp.655~657 (2014), 대한피부과학회
- Shin HT, "Histopathological analysis of the progression pattern of subungual melanoma: late tendency of dermal invasion in the nail matrix area", Mod Pathol, 27, pp.1461~1467 (2014)
- Blessing K, "Comparison of immunohistochemical staining of the novel antibody melan-A with S100 protein and HMB-45 in malignant melanoma and melanoma variants", Histopathology, 32, pp.139~146 (1998)
- Sureda N, "Conservative surgical management of subungual (matrix derived) melanoma: report of seven cases and literature review", Br J Dermatol, 165, pp.852~858 (2011)